Central administration of neuronostatin induces antinociception in mice

► I.c.v. administration of neuronostatin produced a dose- and time-related antinociceptive effect in the tail immersion assay in mice. ► Neuronostatin produces its full analgesic effect by activating μ-and κ-opioid receptors. ► The analgesic effects of neuronostatin are dependent upon the central me...

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Veröffentlicht in:	Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2011-09, Vol.32 (9), p.1893-1901
Hauptverfasser:	Yang, Ai-min, Ge, Wan-wen, Lu, Song-song, Yang, Shao-bin, Su, Shu-fang, Mi, Ze-yun, Chen, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Pain - drug therapy analgesic effect Analgesics Analgesics - administration & dosage Analgesics - pharmacology Animals antagonists Antinociception Biological and medical sciences c-Fos Central melanocortin system Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Immunohistochemistry Infusions, Intraventricular Male mechanism of action Medical sciences Melanocyte-Stimulating Hormones - pharmacology Mice Models, Animal naloxone Naloxone - pharmacology Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists Neuronostatin Neuropharmacology nociception Nociception - drug effects Opioid receptors pain Peptide Hormones - administration & dosage Peptide Hormones - antagonists & inhibitors Peptide Hormones - chemical synthesis Peptide Hormones - pharmacology Periaqueductal Gray - drug effects Pharmacology. Drug treatments protein synthesis Proto-Oncogene Proteins c-fos - metabolism Receptor, Melanocortin, Type 3 - antagonists & inhibitors Receptor, Melanocortin, Type 4 - antagonists & inhibitors receptors somatostatin Vertebrates: endocrinology
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