Angiotensin-II and rosuvastatin influence matrix remodeling in human mesangial cells via metalloproteinase modulation

OBJECTIVEPersistent inflammation and oxidative stress influence the progression of diabetic nephropathy. Metalloproteinases (MMPs) participate in extracellular matrix remodeling. Statins show favorable anti-inflammatory effects in chronic kidney disease. We evaluated the effect of rosuvastatin on in...

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Veröffentlicht in:	Journal of hypertension 2011-10, Vol.29 (10), p.1930-1939
Hauptverfasser:	Solini, Anna, Rossi, Chiara, Santini, Eleonora, Madec, Stephanie, Salvati, Antonio, Ferrannini, Ele
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cells, Cultured Extracellular Matrix - drug effects Extracellular Matrix - metabolism Extracellular Matrix - pathology Fatty Acids, Nonesterified - pharmacology Fibrosis Fluorobenzenes - pharmacology Fundamental and applied biological sciences. Psychology Glucose - pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors Medical sciences Mesangial Cells - drug effects Mesangial Cells - metabolism Mesangial Cells - pathology Metalloproteases - metabolism Pyrimidines - pharmacology RNA, Small Interfering - genetics Rosuvastatin Calcium Sulfonamides - pharmacology Tissue Inhibitor of Metalloproteinase-1 - metabolism Tissue Inhibitor of Metalloproteinase-2 - metabolism Transforming Growth Factor beta - metabolism Vertebrates: cardiovascular system
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