Noninvasive in vitro and in vivo assessment of epidermal hyperkeratosis and dermal fibrosis in atopic dermatitis

Atopic dermatitis (AD) is characterized by hyperkeratosis of epidermis and fibrosis within dermis in chronic skin lesions. Thus far, the histology of skin lesions has been evaluated only by examination of excised specimens. A noninvasive in vivo tool is essential to evaluate the histopathological ch...

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Veröffentlicht in:	Journal of biomedical optics 2009-01, Vol.14 (1), p.014008-014008
Hauptverfasser:	Lee, Jyh-Hong, Chen, Szu-Yu, Yu, Che-Hang, Chu, Shih-Wei, Wang, Li-Fang, Sun, Chi-Kuang, Chiang, Bor-Luen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Biomedical materials Dermatitis, Atopic Dermoscopy - methods Female Fibrosis Hyperkeratosis, Epidermolytic - complications Hyperkeratosis, Epidermolytic - pathology In vitro testing In vivo testing In vivo tests Lesions Mice Mice, Inbred C57BL Mice, Nude Microscopy, Confocal - methods Microscopy, Fluorescence, Multiphoton - methods Reproducibility of Results Sensitivity and Specificity Surgical implants
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