Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin
Accelerated diffusion of water and hyperosmotic optical clearing agents is studied as a result of enhanced epidermal permeability. A lattice of microzones (islets) of damage in is induced using a flash-lamp applique´ system. An optical clearing agent composed of 88 glycerol in aqueous solution is us...
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| Veröffentlicht in: | Journal of Biomedical Optics 2008-03, Vol.13 (2), p.021102-021108 |
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| container_end_page | 021108 |
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| container_issue | 2 |
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| container_title | Journal of Biomedical Optics |
| container_volume | 13 |
| creator | Genina, Elina A Bashkatov, Alexy N Korobko, Anastasiya A Zubkova, Elena A Tuchin, Valery V Yaroslavsky, Ilya Altshuler, Gregory B |
| description | Accelerated diffusion of water and hyperosmotic optical clearing agents is studied as a result of enhanced epidermal permeability. A lattice of microzones (islets) of damage in
is induced using a flash-lamp applique´ system. An optical clearing agent composed of 88 glycerol in aqueous solution is used for all experiments. Research of skin dehydration and glycerol delivery through epidermis at both intact and perforated
is presented. The dehydration process induced by both stimuli of evaporation and osmotic agent action is studied by weight measurements. Dynamics of refractive index alteration of both glycerol solution and water during their interaction with skin samples is monitored. The amounts of water escaping from skin through the
, due to hyperosmotic-agent action, and glycerol penetrating through the skin sample, are estimated. The results show that the proposed method allows for effective transepidermal water loss and delivery of optical clearing agents. |
| doi_str_mv | 10.1117/1.2899149 |
| format | Article |
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is induced using a flash-lamp applique´ system. An optical clearing agent composed of 88 glycerol in aqueous solution is used for all experiments. Research of skin dehydration and glycerol delivery through epidermis at both intact and perforated
is presented. The dehydration process induced by both stimuli of evaporation and osmotic agent action is studied by weight measurements. Dynamics of refractive index alteration of both glycerol solution and water during their interaction with skin samples is monitored. The amounts of water escaping from skin through the
, due to hyperosmotic-agent action, and glycerol penetrating through the skin sample, are estimated. The results show that the proposed method allows for effective transepidermal water loss and delivery of optical clearing agents.</description><identifier>ISSN: 1083-3668</identifier><identifier>EISSN: 1560-2281</identifier><identifier>DOI: 10.1117/1.2899149</identifier><identifier>PMID: 18465951</identifier><identifier>CODEN: JBOPFO</identifier><language>eng</language><publisher>United States</publisher><subject>Alcohols - administration & dosage ; Animals ; Body Water - metabolism ; Clearing ; Damage ; Dehydration ; Dermatologic Agents - administration & dosage ; Diffusion ; glycerol ; Glycerols ; Humans ; In Vitro Techniques ; optical clearing agent delivery ; Permeability ; Permeability - drug effects ; Phototherapy - methods ; Refractometry ; skin ; Skin Absorption - drug effects ; Skin Absorption - physiology ; Skin Physiological Phenomena - drug effects ; Stimuli ; Swine ; Water loss</subject><ispartof>Journal of Biomedical Optics, 2008-03, Vol.13 (2), p.021102-021108</ispartof><rights>2008 Society of Photo-Optical Instrumentation Engineers</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-b66e8caa5fa0dadfae9472a43048c5ae685108fb44d2cd855f8923ac471d87dc3</citedby><cites>FETCH-LOGICAL-c459t-b66e8caa5fa0dadfae9472a43048c5ae685108fb44d2cd855f8923ac471d87dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18465951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Genina, Elina A</creatorcontrib><creatorcontrib>Bashkatov, Alexy N</creatorcontrib><creatorcontrib>Korobko, Anastasiya A</creatorcontrib><creatorcontrib>Zubkova, Elena A</creatorcontrib><creatorcontrib>Tuchin, Valery V</creatorcontrib><creatorcontrib>Yaroslavsky, Ilya</creatorcontrib><creatorcontrib>Altshuler, Gregory B</creatorcontrib><title>Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin</title><title>Journal of Biomedical Optics</title><addtitle>J Biomed Opt</addtitle><description>Accelerated diffusion of water and hyperosmotic optical clearing agents is studied as a result of enhanced epidermal permeability. A lattice of microzones (islets) of damage in
is induced using a flash-lamp applique´ system. An optical clearing agent composed of 88 glycerol in aqueous solution is used for all experiments. Research of skin dehydration and glycerol delivery through epidermis at both intact and perforated
is presented. The dehydration process induced by both stimuli of evaporation and osmotic agent action is studied by weight measurements. Dynamics of refractive index alteration of both glycerol solution and water during their interaction with skin samples is monitored. The amounts of water escaping from skin through the
, due to hyperosmotic-agent action, and glycerol penetrating through the skin sample, are estimated. The results show that the proposed method allows for effective transepidermal water loss and delivery of optical clearing agents.</description><subject>Alcohols - administration & dosage</subject><subject>Animals</subject><subject>Body Water - metabolism</subject><subject>Clearing</subject><subject>Damage</subject><subject>Dehydration</subject><subject>Dermatologic Agents - administration & dosage</subject><subject>Diffusion</subject><subject>glycerol</subject><subject>Glycerols</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>optical clearing agent delivery</subject><subject>Permeability</subject><subject>Permeability - drug effects</subject><subject>Phototherapy - methods</subject><subject>Refractometry</subject><subject>skin</subject><subject>Skin Absorption - drug effects</subject><subject>Skin Absorption - physiology</subject><subject>Skin Physiological Phenomena - drug effects</subject><subject>Stimuli</subject><subject>Swine</subject><subject>Water loss</subject><issn>1083-3668</issn><issn>1560-2281</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALgegHHPoHUE6gHlI8ju3Y3KDqB6jS9gDnaNZ2uoYkDrGDlAu_vU53RW9cxpbnmZGsl5AzoBcAUH-EC6a0Bq5fkGMQkpaMKXiZ71RVZSWlOiInMf6klCqp5WtyBIpLoQUck7-bMXmDXWE6h5MfHorQFru5x6GIv_zwqTChH3HC5P-4IqbZLisY3dQ73PrOp6XAwRbW7Ra7qjCsfT8kNOmpM-5CCmmXB7DrlnWyDRk6-7T_DXnVYhfd28N5Sn5cX32_vC3vNjdfLz_flYYLncqtlE4ZRNEitWhbdJrXDHlFuTICnVQi_7Xdcm6ZsUqIVmlWoeE1WFVbU52SD_u94xR-zy6mpvfRuK7DwYU5NkppTrmEOsv3_5VSg-ac6wzP99BMIcbJtc04-R6npQHarLE00BxiyfbdYem87Z19loccMmB7EEfv_rW_fdncX29ybBSqtVJGGUCu-6dHFBKYJA</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Genina, Elina A</creator><creator>Bashkatov, Alexy N</creator><creator>Korobko, Anastasiya A</creator><creator>Zubkova, Elena A</creator><creator>Tuchin, Valery V</creator><creator>Yaroslavsky, Ilya</creator><creator>Altshuler, Gregory B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope></search><sort><creationdate>20080301</creationdate><title>Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin</title><author>Genina, Elina A ; Bashkatov, Alexy N ; Korobko, Anastasiya A ; Zubkova, Elena A ; Tuchin, Valery V ; Yaroslavsky, Ilya ; Altshuler, Gregory B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-b66e8caa5fa0dadfae9472a43048c5ae685108fb44d2cd855f8923ac471d87dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Alcohols - administration & dosage</topic><topic>Animals</topic><topic>Body Water - metabolism</topic><topic>Clearing</topic><topic>Damage</topic><topic>Dehydration</topic><topic>Dermatologic Agents - administration & dosage</topic><topic>Diffusion</topic><topic>glycerol</topic><topic>Glycerols</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>optical clearing agent delivery</topic><topic>Permeability</topic><topic>Permeability - drug effects</topic><topic>Phototherapy - methods</topic><topic>Refractometry</topic><topic>skin</topic><topic>Skin Absorption - drug effects</topic><topic>Skin Absorption - physiology</topic><topic>Skin Physiological Phenomena - drug effects</topic><topic>Stimuli</topic><topic>Swine</topic><topic>Water loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Genina, Elina A</creatorcontrib><creatorcontrib>Bashkatov, Alexy N</creatorcontrib><creatorcontrib>Korobko, Anastasiya A</creatorcontrib><creatorcontrib>Zubkova, Elena A</creatorcontrib><creatorcontrib>Tuchin, Valery V</creatorcontrib><creatorcontrib>Yaroslavsky, Ilya</creatorcontrib><creatorcontrib>Altshuler, Gregory B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of Biomedical Optics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Genina, Elina A</au><au>Bashkatov, Alexy N</au><au>Korobko, Anastasiya A</au><au>Zubkova, Elena A</au><au>Tuchin, Valery V</au><au>Yaroslavsky, Ilya</au><au>Altshuler, Gregory B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin</atitle><jtitle>Journal of Biomedical Optics</jtitle><addtitle>J Biomed Opt</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>13</volume><issue>2</issue><spage>021102</spage><epage>021108</epage><pages>021102-021108</pages><issn>1083-3668</issn><eissn>1560-2281</eissn><coden>JBOPFO</coden><abstract>Accelerated diffusion of water and hyperosmotic optical clearing agents is studied as a result of enhanced epidermal permeability. A lattice of microzones (islets) of damage in
is induced using a flash-lamp applique´ system. An optical clearing agent composed of 88 glycerol in aqueous solution is used for all experiments. Research of skin dehydration and glycerol delivery through epidermis at both intact and perforated
is presented. The dehydration process induced by both stimuli of evaporation and osmotic agent action is studied by weight measurements. Dynamics of refractive index alteration of both glycerol solution and water during their interaction with skin samples is monitored. The amounts of water escaping from skin through the
, due to hyperosmotic-agent action, and glycerol penetrating through the skin sample, are estimated. The results show that the proposed method allows for effective transepidermal water loss and delivery of optical clearing agents.</abstract><cop>United States</cop><pmid>18465951</pmid><doi>10.1117/1.2899149</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alcohols - administration & dosage Animals Body Water - metabolism Clearing Damage Dehydration Dermatologic Agents - administration & dosage Diffusion glycerol Glycerols Humans In Vitro Techniques optical clearing agent delivery Permeability Permeability - drug effects Phototherapy - methods Refractometry skin Skin Absorption - drug effects Skin Absorption - physiology Skin Physiological Phenomena - drug effects Stimuli Swine Water loss |
| title | Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin |
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