Asymmetric Strecker Synthesis of α-Arylglycines

A practically simple three-component Strecker reaction for the asymmetric synthesis of enantiopure α-arylglycines has been developed. Addition of a range of aryl-aldehydes to a solution of sodium cyanide and (S)-1-(4-methoxyphenyl)ethylamine affords highly crystalline (S,S)-α-aminonitriles that are...

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Veröffentlicht in:	Journal of organic chemistry 2011-08, Vol.76 (15), p.6038-6047
Hauptverfasser:	Pérez-Fuertes, Yolanda, Taylor, James E, Tickell, David A, Mahon, Mary F, Bull, Steven D, James, Tony D
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzaldehydes - chemistry Boronic Acids - chemistry Chemistry Condensed benzenic and aromatic compounds Esters Exact sciences and technology Glycine - analogs & derivatives Glycine - chemical synthesis Glycine - chemistry Hydrolysis Magnetic Resonance Spectroscopy Molecular Structure Noncondensed benzenic compounds Organic chemistry Preparations and properties Stereoisomerism
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