RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature

RB4CD12 is a phage display antibody that recognizes a heparan sulfate (HS) glycosaminoglycan epitope. The epitope structure is proposed to contain a trisulfated disaccharide, [–IdoA(2‐OSO3)‐GlcNSO3(6‐OSO3)–], which supports HS binding to various macromolecules such as growth factors and cytokines in...

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Veröffentlicht in:	Journal of neuroscience research 2011-11, Vol.89 (11), p.1840-1848
Hauptverfasser:	Hosono-Fukao, Tomomi, Ohtake-Niimi, Shiori, Nishitsuji, Kazuchika, Hossain, Md. Motarab, van Kuppevelt, Toin H., Michikawa, Makoto, Uchimura, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies basement membrane Basement membranes Brain brain vessels Cerebral Cortex - immunology Cerebrovascular Circulation - immunology Cytokines Disaccharides Disaccharides - immunology Epitopes Epitopes - immunology Glycosaminoglycans Growth factors Heparan sulfate Heparin Heparitin Sulfate - immunology High-performance liquid chromatography HPLC Immunoelectron microscopy Laminin Macromolecules Mice Nervous system Phage display scFv antibody Western blotting
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