Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease
Abstract Objective Inflammatory bowel disease (IBD) is a chronic inflammatory process in the digestive tract and patients with IBD develop osteopenia. Although vitamins K and D are important for maintaining bone health and inhibiting inflammation, their roles in patients with IBD are not clear. We i...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2011-10, Vol.27 (10), p.1023-1028 |
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| creator | Nakajima, Sachiko, M.D Iijima, Hideki, M.D., Ph.D Egawa, Satoshi, M.D., Ph.D Shinzaki, Shinichiro, M.D., Ph.D Kondo, Jumpei, M.D Inoue, Takahiro, M.D Hayashi, Yoshito, M.D Ying, Jin, M.D Mukai, Akira, M.D Akasaka, Tomofumi, M.D Nishida, Tsutomu, M.D., Ph.D Kanto, Tatsuya, M.D., Ph.D Tsujii, Masahiko, M.D., Ph.D Hayashi, Norio, M.D., Ph.D |
| description | Abstract Objective Inflammatory bowel disease (IBD) is a chronic inflammatory process in the digestive tract and patients with IBD develop osteopenia. Although vitamins K and D are important for maintaining bone health and inhibiting inflammation, their roles in patients with IBD are not clear. We investigated the roles of vitamins K and D in the bone health and inflammation in patients with IBD. Methods Bone mineral density (BMD) of patients with IBD (Crohn’s disease [CD], n = 47, and ulcerative colitis [UC], n = 40) was measured with dual-energy X-ray absorptiometry. Vitamin K and D levels of patients with IBD and healthy volunteers ( n = 41) were evaluated by measuring serum undercarboxylated osteocalcin and 1,25 dihydroxyvitamin D, respectively. Clinical activity index was evaluated in patients with CD and UC. Results BMD was low in patients with CD and UC. Serum undercarboxylated osteocalcin levels were significantly higher in patients with CD, but not with UC, compared with healthy subjects, indicating that bone vitamin K is insufficient in patients with CD. The levels of undercarboxylated osteocalcin were significantly correlated with the clinical activity index of CD, although they were not correlated with BMD. The levels of 1,25 dihydroxyvitamin D were significantly lower in patients with CD and UC than in healthy subjects. The levels of 1,25 dihydroxyvitamin D were inversely correlated with BMD in patients with UC and were not correlated with the clinical activity index of CD. Conclusion Vitamins K and D are insufficient in patients with IBD. Insufficiency of vitamin K is suggested to be associated with inflammatory processes of CD. |
| doi_str_mv | 10.1016/j.nut.2010.10.021 |
| format | Article |
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Although vitamins K and D are important for maintaining bone health and inhibiting inflammation, their roles in patients with IBD are not clear. We investigated the roles of vitamins K and D in the bone health and inflammation in patients with IBD. Methods Bone mineral density (BMD) of patients with IBD (Crohn’s disease [CD], n = 47, and ulcerative colitis [UC], n = 40) was measured with dual-energy X-ray absorptiometry. Vitamin K and D levels of patients with IBD and healthy volunteers ( n = 41) were evaluated by measuring serum undercarboxylated osteocalcin and 1,25 dihydroxyvitamin D, respectively. Clinical activity index was evaluated in patients with CD and UC. Results BMD was low in patients with CD and UC. Serum undercarboxylated osteocalcin levels were significantly higher in patients with CD, but not with UC, compared with healthy subjects, indicating that bone vitamin K is insufficient in patients with CD. The levels of undercarboxylated osteocalcin were significantly correlated with the clinical activity index of CD, although they were not correlated with BMD. The levels of 1,25 dihydroxyvitamin D were significantly lower in patients with CD and UC than in healthy subjects. The levels of 1,25 dihydroxyvitamin D were inversely correlated with BMD in patients with UC and were not correlated with the clinical activity index of CD. Conclusion Vitamins K and D are insufficient in patients with IBD. Insufficiency of vitamin K is suggested to be associated with inflammatory processes of CD.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2010.10.021</identifier><identifier>PMID: 21482072</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Bone and Bones - metabolism ; Bone Density ; bone metabolism ; Bone mineral density ; Bones ; Clinical disease activity ; colitis ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - complications ; Crohn disease ; Crohn Disease - blood ; Crohn Disease - complications ; Cytokines ; digestive tract ; dual-energy X-ray absorptiometry ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Hepatology ; Homeostasis ; Humans ; Hydroxycholecalciferols - blood ; inflammation ; Inflammatory bowel disease ; International organizations ; Male ; Middle Aged ; Older people ; osteocalcin ; Osteocalcin - blood ; Osteopenia ; patients ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; vitamin deficiencies ; Vitamin K ; Vitamin K Deficiency - blood ; Vitamin K Deficiency - complications ; Vitamins ; volunteers</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2011-10, Vol.27 (10), p.1023-1028</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-d35a0871d97c16d1d1b2ed096998e35f65bce614a544bf625c884e6f5c187a103</citedby><cites>FETCH-LOGICAL-c489t-d35a0871d97c16d1d1b2ed096998e35f65bce614a544bf625c884e6f5c187a103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1130335851?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24572757$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21482072$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakajima, Sachiko, M.D</creatorcontrib><creatorcontrib>Iijima, Hideki, M.D., Ph.D</creatorcontrib><creatorcontrib>Egawa, Satoshi, M.D., Ph.D</creatorcontrib><creatorcontrib>Shinzaki, Shinichiro, M.D., Ph.D</creatorcontrib><creatorcontrib>Kondo, Jumpei, M.D</creatorcontrib><creatorcontrib>Inoue, Takahiro, M.D</creatorcontrib><creatorcontrib>Hayashi, Yoshito, M.D</creatorcontrib><creatorcontrib>Ying, Jin, M.D</creatorcontrib><creatorcontrib>Mukai, Akira, M.D</creatorcontrib><creatorcontrib>Akasaka, Tomofumi, M.D</creatorcontrib><creatorcontrib>Nishida, Tsutomu, M.D., Ph.D</creatorcontrib><creatorcontrib>Kanto, Tatsuya, M.D., Ph.D</creatorcontrib><creatorcontrib>Tsujii, Masahiko, M.D., Ph.D</creatorcontrib><creatorcontrib>Hayashi, Norio, M.D., Ph.D</creatorcontrib><title>Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objective Inflammatory bowel disease (IBD) is a chronic inflammatory process in the digestive tract and patients with IBD develop osteopenia. Although vitamins K and D are important for maintaining bone health and inhibiting inflammation, their roles in patients with IBD are not clear. We investigated the roles of vitamins K and D in the bone health and inflammation in patients with IBD. Methods Bone mineral density (BMD) of patients with IBD (Crohn’s disease [CD], n = 47, and ulcerative colitis [UC], n = 40) was measured with dual-energy X-ray absorptiometry. Vitamin K and D levels of patients with IBD and healthy volunteers ( n = 41) were evaluated by measuring serum undercarboxylated osteocalcin and 1,25 dihydroxyvitamin D, respectively. Clinical activity index was evaluated in patients with CD and UC. Results BMD was low in patients with CD and UC. Serum undercarboxylated osteocalcin levels were significantly higher in patients with CD, but not with UC, compared with healthy subjects, indicating that bone vitamin K is insufficient in patients with CD. The levels of undercarboxylated osteocalcin were significantly correlated with the clinical activity index of CD, although they were not correlated with BMD. The levels of 1,25 dihydroxyvitamin D were significantly lower in patients with CD and UC than in healthy subjects. The levels of 1,25 dihydroxyvitamin D were inversely correlated with BMD in patients with UC and were not correlated with the clinical activity index of CD. Conclusion Vitamins K and D are insufficient in patients with IBD. Insufficiency of vitamin K is suggested to be associated with inflammatory processes of CD.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Density</subject><subject>bone metabolism</subject><subject>Bone mineral density</subject><subject>Bones</subject><subject>Clinical disease activity</subject><subject>colitis</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - complications</subject><subject>Crohn disease</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - complications</subject><subject>Cytokines</subject><subject>digestive tract</subject><subject>dual-energy X-ray absorptiometry</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Hepatology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hydroxycholecalciferols - blood</subject><subject>inflammation</subject><subject>Inflammatory bowel disease</subject><subject>International organizations</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>Osteopenia</subject><subject>patients</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>vitamin deficiencies</subject><subject>Vitamin K</subject><subject>Vitamin K Deficiency - blood</subject><subject>Vitamin K Deficiency - complications</subject><subject>Vitamins</subject><subject>volunteers</subject><issn>0899-9007</issn><issn>1873-1244</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ks1u1DAUhSMEokPhAdiAJYRYZfBN7NgRElJV8ScqsShdW459Ax4Su9hOq3l7PJ1pK3XBKnL0nePrc25VvQS6Bgrd-83aL3nd0JvzmjbwqFqBFG0NDWOPqxWVfV_3lIqj6llKG0op9F3_tDpqgMmGimZV5ZOUgnE6u-BJGMmVy3p2nnwnFkdnHHqzJdcu_yZD8EhmzHoIk0sz0d4SMznvjJ6IdQl1QqJNdsViS4qF8-Ok51nnELdFfY132PPqyainhC8O3-Pq4vOnn6df67MfX76dnpzVhsk-17blmkoBthcGOgsWhgYtLU_oJbZ87PhgsAOmOWPD2DXcSMmwG7kpIWig7XH1bu97GcPfBVNWs0sGp0l7DEtSUvYgRE-7Qr55QG7CEn0ZTgG0tG255FAo2FMmhpQijuoyulnHrQKqdo2ojSqNqF0ju1-lkaJ5dXBehhntneK2ggK8PQA6lSjHqL1x6Z5jXDSCi8K93nOjDkr_ioW5OC83sdKq6CTwQnzYE1gyvXIYVbopEK2LaLKywf130I8P1Lft_sEtpvs8VGoUVee75drtFpS1KjOw9h_hH8cN</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Nakajima, Sachiko, M.D</creator><creator>Iijima, Hideki, M.D., Ph.D</creator><creator>Egawa, Satoshi, M.D., Ph.D</creator><creator>Shinzaki, Shinichiro, M.D., Ph.D</creator><creator>Kondo, Jumpei, M.D</creator><creator>Inoue, Takahiro, M.D</creator><creator>Hayashi, Yoshito, M.D</creator><creator>Ying, Jin, M.D</creator><creator>Mukai, Akira, M.D</creator><creator>Akasaka, Tomofumi, M.D</creator><creator>Nishida, Tsutomu, M.D., Ph.D</creator><creator>Kanto, Tatsuya, M.D., Ph.D</creator><creator>Tsujii, Masahiko, M.D., Ph.D</creator><creator>Hayashi, Norio, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease</title><author>Nakajima, Sachiko, M.D ; Iijima, Hideki, M.D., Ph.D ; Egawa, Satoshi, M.D., Ph.D ; Shinzaki, Shinichiro, M.D., Ph.D ; Kondo, Jumpei, M.D ; Inoue, Takahiro, M.D ; Hayashi, Yoshito, M.D ; Ying, Jin, M.D ; Mukai, Akira, M.D ; Akasaka, Tomofumi, M.D ; Nishida, Tsutomu, M.D., Ph.D ; Kanto, Tatsuya, M.D., Ph.D ; Tsujii, Masahiko, M.D., Ph.D ; Hayashi, Norio, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-d35a0871d97c16d1d1b2ed096998e35f65bce614a544bf625c884e6f5c187a103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Density</topic><topic>bone metabolism</topic><topic>Bone mineral density</topic><topic>Bones</topic><topic>Clinical disease activity</topic><topic>colitis</topic><topic>Colitis, Ulcerative - blood</topic><topic>Colitis, Ulcerative - complications</topic><topic>Crohn disease</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - complications</topic><topic>Cytokines</topic><topic>digestive tract</topic><topic>dual-energy X-ray absorptiometry</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. 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Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakajima, Sachiko, M.D</au><au>Iijima, Hideki, M.D., Ph.D</au><au>Egawa, Satoshi, M.D., Ph.D</au><au>Shinzaki, Shinichiro, M.D., Ph.D</au><au>Kondo, Jumpei, M.D</au><au>Inoue, Takahiro, M.D</au><au>Hayashi, Yoshito, M.D</au><au>Ying, Jin, M.D</au><au>Mukai, Akira, M.D</au><au>Akasaka, Tomofumi, M.D</au><au>Nishida, Tsutomu, M.D., Ph.D</au><au>Kanto, Tatsuya, M.D., Ph.D</au><au>Tsujii, Masahiko, M.D., Ph.D</au><au>Hayashi, Norio, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>27</volume><issue>10</issue><spage>1023</spage><epage>1028</epage><pages>1023-1028</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><abstract>Abstract Objective Inflammatory bowel disease (IBD) is a chronic inflammatory process in the digestive tract and patients with IBD develop osteopenia. Although vitamins K and D are important for maintaining bone health and inhibiting inflammation, their roles in patients with IBD are not clear. We investigated the roles of vitamins K and D in the bone health and inflammation in patients with IBD. Methods Bone mineral density (BMD) of patients with IBD (Crohn’s disease [CD], n = 47, and ulcerative colitis [UC], n = 40) was measured with dual-energy X-ray absorptiometry. Vitamin K and D levels of patients with IBD and healthy volunteers ( n = 41) were evaluated by measuring serum undercarboxylated osteocalcin and 1,25 dihydroxyvitamin D, respectively. Clinical activity index was evaluated in patients with CD and UC. Results BMD was low in patients with CD and UC. Serum undercarboxylated osteocalcin levels were significantly higher in patients with CD, but not with UC, compared with healthy subjects, indicating that bone vitamin K is insufficient in patients with CD. The levels of undercarboxylated osteocalcin were significantly correlated with the clinical activity index of CD, although they were not correlated with BMD. The levels of 1,25 dihydroxyvitamin D were significantly lower in patients with CD and UC than in healthy subjects. The levels of 1,25 dihydroxyvitamin D were inversely correlated with BMD in patients with UC and were not correlated with the clinical activity index of CD. Conclusion Vitamins K and D are insufficient in patients with IBD. Insufficiency of vitamin K is suggested to be associated with inflammatory processes of CD.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21482072</pmid><doi>10.1016/j.nut.2010.10.021</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0899-9007 |
| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2011-10, Vol.27 (10), p.1023-1028 |
| issn | 0899-9007 1873-1244 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_889177906 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Adult Biological and medical sciences Bone and Bones - metabolism Bone Density bone metabolism Bone mineral density Bones Clinical disease activity colitis Colitis, Ulcerative - blood Colitis, Ulcerative - complications Crohn disease Crohn Disease - blood Crohn Disease - complications Cytokines digestive tract dual-energy X-ray absorptiometry Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Hepatology Homeostasis Humans Hydroxycholecalciferols - blood inflammation Inflammatory bowel disease International organizations Male Middle Aged Older people osteocalcin Osteocalcin - blood Osteopenia patients Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D Deficiency - blood Vitamin D Deficiency - complications vitamin deficiencies Vitamin K Vitamin K Deficiency - blood Vitamin K Deficiency - complications Vitamins volunteers |
| title | Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T16%3A34%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20vitamin%20K%20deficiency%20with%20bone%20metabolism%20and%20clinical%20disease%20activity%20in%20inflammatory%20bowel%20disease&rft.jtitle=Nutrition%20(Burbank,%20Los%20Angeles%20County,%20Calif.)&rft.au=Nakajima,%20Sachiko,%20M.D&rft.date=2011-10-01&rft.volume=27&rft.issue=10&rft.spage=1023&rft.epage=1028&rft.pages=1023-1028&rft.issn=0899-9007&rft.eissn=1873-1244&rft.coden=NUTRER&rft_id=info:doi/10.1016/j.nut.2010.10.021&rft_dat=%3Cproquest_cross%3E2807301731%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1130335851&rft_id=info:pmid/21482072&rft_els_id=1_s2_0_S0899900710004004&rfr_iscdi=true |