Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling

The mammalian nicotinamide‐adenine dinucleotide (NAD)‐dependent deacetylase Sirt1 impacts different processes involved in the maintenance of brain integrity and in the pathogenic pathways associated with several neurodegenerative disorders, including Alzheimer's disease. Here we used human Sirt...

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Veröffentlicht in:	Journal of neuroscience research 2011-11, Vol.89 (11), p.1723-1736
Hauptverfasser:	Guo, Wenjing, Qian, Lei, Zhang, Jing, Zhang, Wei, Morrison, Alastair, Hayes, Philip, Wilson, Steve, Chen, Tongsheng, Zhao, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease amyloid Animals Axonogenesis Brain Cell death Cell survival Cell Survival - physiology Cells, Cultured Central nervous system dendrites Mice Mice, Transgenic mRNA Neurites - metabolism Neurodegenerative diseases Neurons Neurons - metabolism neurotoxicity Nutrients Phosphorylation Rapamycin Ribosomal protein S6 kinase Signal transduction Signal Transduction - physiology siRNA SIRT1 protein Sirtuin 1 - genetics Sirtuin 1 - metabolism TOR protein TOR Serine-Threonine Kinases - metabolism Transfection Transgenic mice
Online-Zugang:	Volltext
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