Thromboembolism in pediatric inflammatory bowel disease: Systematic review
Background: Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD. Methods: We se...
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| Veröffentlicht in: | Inflammatory bowel diseases 2011-10, Vol.17 (10), p.2174-2183 |
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| creator | Lazzerini, Marzia Bramuzzo, Matteo Maschio, Massimo Martelossi, Stefano Ventura, Alessandro |
| description | Background:
Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD.
Methods:
We searched Medline, LILACS, EMBASE, POPLINE, CINHAL, and reference lists of identified articles, without language restrictions, in August 2010.
Results:
Population studies suggest that there is an increased risk of TE in children with IBD compared to controls. TE occurred in children with IBD in all age ranges, mostly (82.8%) during active disease, and more frequently in children with ulcerative colitis (odds ratio [OR] 3.7, 95% confidence interval [CI] 1.8–7.6). At least one specific risk factor for TE was recognized in 50% of cases; two risk factors were present in 24%. Out of 92 published cases of TE in children with IBD, 54.3% occurred in cerebral site, 26% in the limbs, 13% in the abdominal vessels, and the remaining in the retina and lungs. After a first episode of TE, an early recurrence was observed in 11.4% of children, a late recurrence in 10%. A number of different therapeutic schemes were used. Overall mortality was 5.7% and was mostly associated with cerebral TE.
Conclusions:
Population studies are needed to clarify the risk of TE in children with IBD, the relative weight of other risk factors, the characteristics of the events, and to define guidelines of therapy and prophylaxis. (Inflamm Bowel Dis 2010) |
| doi_str_mv | 10.1002/ibd.21563 |
| format | Article |
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Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD.
Methods:
We searched Medline, LILACS, EMBASE, POPLINE, CINHAL, and reference lists of identified articles, without language restrictions, in August 2010.
Results:
Population studies suggest that there is an increased risk of TE in children with IBD compared to controls. TE occurred in children with IBD in all age ranges, mostly (82.8%) during active disease, and more frequently in children with ulcerative colitis (odds ratio [OR] 3.7, 95% confidence interval [CI] 1.8–7.6). At least one specific risk factor for TE was recognized in 50% of cases; two risk factors were present in 24%. Out of 92 published cases of TE in children with IBD, 54.3% occurred in cerebral site, 26% in the limbs, 13% in the abdominal vessels, and the remaining in the retina and lungs. After a first episode of TE, an early recurrence was observed in 11.4% of children, a late recurrence in 10%. A number of different therapeutic schemes were used. Overall mortality was 5.7% and was mostly associated with cerebral TE.
Conclusions:
Population studies are needed to clarify the risk of TE in children with IBD, the relative weight of other risk factors, the characteristics of the events, and to define guidelines of therapy and prophylaxis. (Inflamm Bowel Dis 2010)</description><identifier>ISSN: 1078-0998</identifier><identifier>ISSN: 1536-4844</identifier><identifier>EISSN: 1536-4844</identifier><identifier>DOI: 10.1002/ibd.21563</identifier><identifier>PMID: 21910180</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Age ; Child ; Children ; Humans ; inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - complications ; Intestine ; Language ; Limbs ; Lung ; Mortality ; pediatric ; Pediatrics ; Population studies ; Prophylaxis ; Retina ; Risk Factors ; Thromboembolism ; Thromboembolism - etiology ; Ulcerative colitis</subject><ispartof>Inflammatory bowel diseases, 2011-10, Vol.17 (10), p.2174-2183</ispartof><rights>Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3923-1dcdd4ad215041fa7c7c150e17aacd15a225602a89e5cc595ad0ee9d964b24273</citedby><cites>FETCH-LOGICAL-c3923-1dcdd4ad215041fa7c7c150e17aacd15a225602a89e5cc595ad0ee9d964b24273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fibd.21563$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fibd.21563$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21910180$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lazzerini, Marzia</creatorcontrib><creatorcontrib>Bramuzzo, Matteo</creatorcontrib><creatorcontrib>Maschio, Massimo</creatorcontrib><creatorcontrib>Martelossi, Stefano</creatorcontrib><creatorcontrib>Ventura, Alessandro</creatorcontrib><title>Thromboembolism in pediatric inflammatory bowel disease: Systematic review</title><title>Inflammatory bowel diseases</title><addtitle>Inflamm Bowel Dis</addtitle><description>Background:
Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD.
Methods:
We searched Medline, LILACS, EMBASE, POPLINE, CINHAL, and reference lists of identified articles, without language restrictions, in August 2010.
Results:
Population studies suggest that there is an increased risk of TE in children with IBD compared to controls. TE occurred in children with IBD in all age ranges, mostly (82.8%) during active disease, and more frequently in children with ulcerative colitis (odds ratio [OR] 3.7, 95% confidence interval [CI] 1.8–7.6). At least one specific risk factor for TE was recognized in 50% of cases; two risk factors were present in 24%. Out of 92 published cases of TE in children with IBD, 54.3% occurred in cerebral site, 26% in the limbs, 13% in the abdominal vessels, and the remaining in the retina and lungs. After a first episode of TE, an early recurrence was observed in 11.4% of children, a late recurrence in 10%. A number of different therapeutic schemes were used. Overall mortality was 5.7% and was mostly associated with cerebral TE.
Conclusions:
Population studies are needed to clarify the risk of TE in children with IBD, the relative weight of other risk factors, the characteristics of the events, and to define guidelines of therapy and prophylaxis. (Inflamm Bowel Dis 2010)</description><subject>Adult</subject><subject>Age</subject><subject>Child</subject><subject>Children</subject><subject>Humans</subject><subject>inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Intestine</subject><subject>Language</subject><subject>Limbs</subject><subject>Lung</subject><subject>Mortality</subject><subject>pediatric</subject><subject>Pediatrics</subject><subject>Population studies</subject><subject>Prophylaxis</subject><subject>Retina</subject><subject>Risk Factors</subject><subject>Thromboembolism</subject><subject>Thromboembolism - etiology</subject><subject>Ulcerative colitis</subject><issn>1078-0998</issn><issn>1536-4844</issn><issn>1536-4844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90E1PwyAYB3BiNG6-HPwCpjf10A0oFPCm821miQfnuaHwLGLadULn0m8v2ulNQwgP4Zd_yB-hE4JHBGM6dqUdUcLzbAcNCc_ylEnGduOMhUyxUnKADkJ4izQutY8GlCiCicRD9Dh_9U1dNhB35UKduGWyAut0652Jl0Wl61q3je-SstlAlVgXQAe4TJ670EJ8iszDh4PNEdpb6CrA8fY8RC93t_PJQzp7up9OrmapyRTNUmKNtUzb-GHMyEILI0wcgQitjSVcU8pzTLVUwI3himuLAZRVOSspoyI7RGd97so372sIbVG7YKCq9BKadSikVETkMudRnv8rYwdCCcqyLNKLnhrfhOBhUay8q7XvIiq-Si5iycV3ydGebmPXZQ32V_60GsG4BxtXQfd3UjG9vukjPwGRyIX6</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Lazzerini, Marzia</creator><creator>Bramuzzo, Matteo</creator><creator>Maschio, Massimo</creator><creator>Martelossi, Stefano</creator><creator>Ventura, Alessandro</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Thromboembolism in pediatric inflammatory bowel disease: Systematic review</title><author>Lazzerini, Marzia ; Bramuzzo, Matteo ; Maschio, Massimo ; Martelossi, Stefano ; Ventura, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3923-1dcdd4ad215041fa7c7c150e17aacd15a225602a89e5cc595ad0ee9d964b24273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Child</topic><topic>Children</topic><topic>Humans</topic><topic>inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Intestine</topic><topic>Language</topic><topic>Limbs</topic><topic>Lung</topic><topic>Mortality</topic><topic>pediatric</topic><topic>Pediatrics</topic><topic>Population studies</topic><topic>Prophylaxis</topic><topic>Retina</topic><topic>Risk Factors</topic><topic>Thromboembolism</topic><topic>Thromboembolism - etiology</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lazzerini, Marzia</creatorcontrib><creatorcontrib>Bramuzzo, Matteo</creatorcontrib><creatorcontrib>Maschio, Massimo</creatorcontrib><creatorcontrib>Martelossi, Stefano</creatorcontrib><creatorcontrib>Ventura, Alessandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammatory bowel diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lazzerini, Marzia</au><au>Bramuzzo, Matteo</au><au>Maschio, Massimo</au><au>Martelossi, Stefano</au><au>Ventura, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thromboembolism in pediatric inflammatory bowel disease: Systematic review</atitle><jtitle>Inflammatory bowel diseases</jtitle><addtitle>Inflamm Bowel Dis</addtitle><date>2011-10</date><risdate>2011</risdate><volume>17</volume><issue>10</issue><spage>2174</spage><epage>2183</epage><pages>2174-2183</pages><issn>1078-0998</issn><issn>1536-4844</issn><eissn>1536-4844</eissn><abstract>Background:
Several studies suggest an increased risk of venous and arterial thromboembolism (TE) in adults with inflammatory bowel disease (IBD) compared to the general population. We performed a systematic review of studies on incidence and characteristic of TE in children with IBD.
Methods:
We searched Medline, LILACS, EMBASE, POPLINE, CINHAL, and reference lists of identified articles, without language restrictions, in August 2010.
Results:
Population studies suggest that there is an increased risk of TE in children with IBD compared to controls. TE occurred in children with IBD in all age ranges, mostly (82.8%) during active disease, and more frequently in children with ulcerative colitis (odds ratio [OR] 3.7, 95% confidence interval [CI] 1.8–7.6). At least one specific risk factor for TE was recognized in 50% of cases; two risk factors were present in 24%. Out of 92 published cases of TE in children with IBD, 54.3% occurred in cerebral site, 26% in the limbs, 13% in the abdominal vessels, and the remaining in the retina and lungs. After a first episode of TE, an early recurrence was observed in 11.4% of children, a late recurrence in 10%. A number of different therapeutic schemes were used. Overall mortality was 5.7% and was mostly associated with cerebral TE.
Conclusions:
Population studies are needed to clarify the risk of TE in children with IBD, the relative weight of other risk factors, the characteristics of the events, and to define guidelines of therapy and prophylaxis. (Inflamm Bowel Dis 2010)</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21910180</pmid><doi>10.1002/ibd.21563</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adult Age Child Children Humans inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - complications Intestine Language Limbs Lung Mortality pediatric Pediatrics Population studies Prophylaxis Retina Risk Factors Thromboembolism Thromboembolism - etiology Ulcerative colitis |
| title | Thromboembolism in pediatric inflammatory bowel disease: Systematic review |
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