Obesity, adipose tissue and rheumatoid arthritis: coincidence or more complex relationship?
In the last two decades we have witnessed a boost in scientific interest and knowledge of adipose tissue biology to such an extent that it was promoted to an active endocrine organ. Adipose tissue is not just related to body weight and appetite regulation. It is also implicated in obesity, a low-gra...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2011-07, Vol.29 (4), p.712-727 |
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| container_title | Clinical and experimental rheumatology |
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| creator | DERDEMEZIS, C. S VOULGARI, P. V DROSOS, A. A KIORTSIS, D. N |
| description | In the last two decades we have witnessed a boost in scientific interest and knowledge of adipose tissue biology to such an extent that it was promoted to an active endocrine organ. Adipose tissue is not just related to body weight and appetite regulation. It is also implicated in obesity, a low-grade inflammatory state, as well as inflammatory conditions including rheumatoid arthritis (RA), an autoimmune disease where anti- and pro-inflammatory cytokine balance is critical. All major adipose derived products, simply termed adipokines, like leptin, adiponectin, visfatin and resistin, reportedly participate in inflammation and immunity. In this review we explore in depth the relationship between adipose tissue and RA, with focus on possible mechanisms, beyond observations about circulating or synovial levels, and special reference to future perspectives and clinical implications. |
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| ispartof | Clinical and experimental rheumatology, 2011-07, Vol.29 (4), p.712-727 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adipokines - metabolism Adipose Tissue - immunology Animals Arthritis, Rheumatoid - immunology Autoimmunity Biological and medical sciences Diseases of the osteoarticular system Humans Inflammation Mediators - metabolism Inflammatory joint diseases Medical sciences Metabolic diseases Obesity Obesity - complications Obesity - immunology Risk Assessment Risk Factors |
| title | Obesity, adipose tissue and rheumatoid arthritis: coincidence or more complex relationship? |
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