C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes

Aims/hypothesis Although C-reactive protein (CRP) has been implicated as a risk factor in diabetes, its pathogenic importance in diabetic kidney disease (DKD) remains unclear. The present study investigated the potential role of CRP in DKD. Methods Diabetes was induced by streptozotocin in human CRP...

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Veröffentlicht in:	Diabetologia 2011-10, Vol.54 (10), p.2713-2723
Hauptverfasser:	Liu, F., Chen, H. Y., Huang, X. R., Chung, A. C. K., Zhou, L., Fu, P., Szalai, A. J., Lan, H. Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Associated diseases and complications Biological and medical sciences Biomarkers Blood pressure Blotting, Western C-Reactive Protein - genetics C-Reactive Protein - metabolism Cardiovascular disease Cell Line Chemokine CCL2 - metabolism Connective tissue Connective Tissue Growth Factor - metabolism Cytokines Diabetes Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - metabolism Diabetes. Impaired glucose tolerance Diabetic Nephropathies - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose Growth factors Human Physiology Immunohistochemistry Inflammation Internal Medicine Kidney diseases Kidneys Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Transgenic Nephrology. Urinary tract diseases NF-kappa B - metabolism Proteins Real-Time Polymerase Chain Reaction Transforming Growth Factor beta1 - metabolism Transgenic animals Urinary system involvement in other diseases. Miscellaneous
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