Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy
To investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-he...
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| Veröffentlicht in: | Molecular medicine reports 2011-11, Vol.4 (6), p.1219-1223 |
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| creator | Xie, Yi-qiang Wang, Hua Wu, Yue-ping Yin, De-hui Wang, Zhuan-suo Huang, Yong-hao |
| description | To investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficiency of yin, Qi-Yin deficiency, and Yin-Yang deficiency, according to the TCM syndromes, with a control group of 20 healthy individuals. APOE genotype analysis was performed with polymerase chain reaction amplification and restriction fragment length polymorphism, and the results showed that the proportion of the ε4/4 and ε3/4 genotypes and frequencies of the ε4 and ε3 alleles were higher in the Qi-Yin deficiency group (P |
| doi_str_mv | 10.3892/mmr.2011.546 |
| format | Article |
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APOE genotype analysis was performed with polymerase chain reaction amplification and restriction fragment length polymorphism, and the results showed that the proportion of the ε4/4 and ε3/4 genotypes and frequencies of the ε4 and ε3 alleles were higher in the Qi-Yin deficiency group (P<0.05). Among the T2DM macroangiopathy patients, the E4 group had the largest number of cases, as well as a significantly longer disease course compared to the E2 group (P<0.05). The insulin resistance index (IRI), insulin action index and body mass index (BMI) of patients in the Yin-Yang deficiency group were significantly different from those of patients with dryness-heat due to deficiency of yin and Qi-Yin deficiency. Furthermore, correlation analysis of the BMI and IRI of patients in the Yin-Yang deficiency group revealed a correlation coefficient r=0.696 (P<0.01) and a typical correlation between them. In conclusion, the Qi-Yin deficiency in T2DM patients with macroangiopathy is associated with the APOE E4 and E3 genotypes. Thus, the APOE gene polymorphism can, to some degree, reflect the TCM syndrome types of T2DM patients with macroangiopathy. Insulin resistance plays an important role in the occurrence of T2DM macroangiopathy and is closely associated with the Yin-Yang deficiency according to the TCM differentiating types.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2011.546</identifier><identifier>PMID: 21822540</identifier><language>eng</language><publisher>Greece</publisher><subject>Aged ; Apolipoproteins E - genetics ; Body Mass Index ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Diabetic Angiopathies - complications ; Diabetic Angiopathies - genetics ; Female ; Gene Frequency ; Genotype ; Humans ; Insulin Resistance ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Polymorphism, Genetic ; Protein Isoforms - genetics ; Syndrome ; Yang Deficiency - classification ; Yang Deficiency - complications ; Yang Deficiency - genetics ; Yin Deficiency - classification ; Yin Deficiency - complications ; Yin Deficiency - genetics</subject><ispartof>Molecular medicine reports, 2011-11, Vol.4 (6), p.1219-1223</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-16f37b5fb11c79b4b25def06a14f91412ccfc617cd59cac8ffbfdd4e2a3f15953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21822540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Yi-qiang</creatorcontrib><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Wu, Yue-ping</creatorcontrib><creatorcontrib>Yin, De-hui</creatorcontrib><creatorcontrib>Wang, Zhuan-suo</creatorcontrib><creatorcontrib>Huang, Yong-hao</creatorcontrib><title>Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>To investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficiency of yin, Qi-Yin deficiency, and Yin-Yang deficiency, according to the TCM syndromes, with a control group of 20 healthy individuals. APOE genotype analysis was performed with polymerase chain reaction amplification and restriction fragment length polymorphism, and the results showed that the proportion of the ε4/4 and ε3/4 genotypes and frequencies of the ε4 and ε3 alleles were higher in the Qi-Yin deficiency group (P<0.05). Among the T2DM macroangiopathy patients, the E4 group had the largest number of cases, as well as a significantly longer disease course compared to the E2 group (P<0.05). The insulin resistance index (IRI), insulin action index and body mass index (BMI) of patients in the Yin-Yang deficiency group were significantly different from those of patients with dryness-heat due to deficiency of yin and Qi-Yin deficiency. Furthermore, correlation analysis of the BMI and IRI of patients in the Yin-Yang deficiency group revealed a correlation coefficient r=0.696 (P<0.01) and a typical correlation between them. In conclusion, the Qi-Yin deficiency in T2DM patients with macroangiopathy is associated with the APOE E4 and E3 genotypes. Thus, the APOE gene polymorphism can, to some degree, reflect the TCM syndrome types of T2DM patients with macroangiopathy. Insulin resistance plays an important role in the occurrence of T2DM macroangiopathy and is closely associated with the Yin-Yang deficiency according to the TCM differentiating types.</description><subject>Aged</subject><subject>Apolipoproteins E - genetics</subject><subject>Body Mass Index</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetic Angiopathies - complications</subject><subject>Diabetic Angiopathies - genetics</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Insulin Resistance</subject><subject>Male</subject><subject>Medicine, Chinese Traditional</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Protein Isoforms - genetics</subject><subject>Syndrome</subject><subject>Yang Deficiency - classification</subject><subject>Yang Deficiency - complications</subject><subject>Yang Deficiency - genetics</subject><subject>Yin Deficiency - classification</subject><subject>Yin Deficiency - complications</subject><subject>Yin Deficiency - genetics</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhYMovneuJTs3zphH0zbLYRgfoOhC1yVNEyfSJDW3gxT88UZmdHUPh4_D5UPogpI5ryW78T7NGaF0LopyDx3TStIZJ6TY32UmZXWETgA-CCkFE_IQHTFaMyYKcoy-FwBROzW6GHC0ePHyvMJD7Ccf07B24AGr0GEXYNO7gJMBB6MK2uAvN67x6_IJwxS6FL2BTOFxGgxmuHOqNWOuhrxswghb3CudogrvLuZ-PZ2hA6t6MOe7e4reblevy_vZ4_Pdw3LxONOc1eOMlpZXrbAtpbqSbdEy0RlLSkULK2lBmdZWl7TSnZBa6dra1nZdYZjilgop-Cm62u4OKX5uDIyNd6BN36tg4gaauq45r6SkmbzekvlPgGRsMyTnVZoaSppf3U3W3fzqbrLujF_uhjetN90__OeX_wBGSn6f</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Xie, Yi-qiang</creator><creator>Wang, Hua</creator><creator>Wu, Yue-ping</creator><creator>Yin, De-hui</creator><creator>Wang, Zhuan-suo</creator><creator>Huang, Yong-hao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111101</creationdate><title>Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy</title><author>Xie, Yi-qiang ; Wang, Hua ; Wu, Yue-ping ; Yin, De-hui ; Wang, Zhuan-suo ; Huang, Yong-hao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-16f37b5fb11c79b4b25def06a14f91412ccfc617cd59cac8ffbfdd4e2a3f15953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Apolipoproteins E - genetics</topic><topic>Body Mass Index</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetic Angiopathies - complications</topic><topic>Diabetic Angiopathies - genetics</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Insulin Resistance</topic><topic>Male</topic><topic>Medicine, Chinese Traditional</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Protein Isoforms - genetics</topic><topic>Syndrome</topic><topic>Yang Deficiency - classification</topic><topic>Yang Deficiency - complications</topic><topic>Yang Deficiency - genetics</topic><topic>Yin Deficiency - classification</topic><topic>Yin Deficiency - complications</topic><topic>Yin Deficiency - genetics</topic><toplevel>online_resources</toplevel><creatorcontrib>Xie, Yi-qiang</creatorcontrib><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Wu, Yue-ping</creatorcontrib><creatorcontrib>Yin, De-hui</creatorcontrib><creatorcontrib>Wang, Zhuan-suo</creatorcontrib><creatorcontrib>Huang, Yong-hao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Yi-qiang</au><au>Wang, Hua</au><au>Wu, Yue-ping</au><au>Yin, De-hui</au><au>Wang, Zhuan-suo</au><au>Huang, Yong-hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>4</volume><issue>6</issue><spage>1219</spage><epage>1223</epage><pages>1219-1223</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>To investigate the association between apolipo-protein E (APOE) polymorphisms and insulin resistance and Traditional Chinese Medicine (TCM) syndromes in type 2 diabetes mellitus (T2DM) with macroangiopathy, 60 patients with T2DM macroangiopathy were enrolled and divided into three groups: dryness-heat due to deficiency of yin, Qi-Yin deficiency, and Yin-Yang deficiency, according to the TCM syndromes, with a control group of 20 healthy individuals. APOE genotype analysis was performed with polymerase chain reaction amplification and restriction fragment length polymorphism, and the results showed that the proportion of the ε4/4 and ε3/4 genotypes and frequencies of the ε4 and ε3 alleles were higher in the Qi-Yin deficiency group (P<0.05). Among the T2DM macroangiopathy patients, the E4 group had the largest number of cases, as well as a significantly longer disease course compared to the E2 group (P<0.05). The insulin resistance index (IRI), insulin action index and body mass index (BMI) of patients in the Yin-Yang deficiency group were significantly different from those of patients with dryness-heat due to deficiency of yin and Qi-Yin deficiency. Furthermore, correlation analysis of the BMI and IRI of patients in the Yin-Yang deficiency group revealed a correlation coefficient r=0.696 (P<0.01) and a typical correlation between them. In conclusion, the Qi-Yin deficiency in T2DM patients with macroangiopathy is associated with the APOE E4 and E3 genotypes. Thus, the APOE gene polymorphism can, to some degree, reflect the TCM syndrome types of T2DM patients with macroangiopathy. Insulin resistance plays an important role in the occurrence of T2DM macroangiopathy and is closely associated with the Yin-Yang deficiency according to the TCM differentiating types.</abstract><cop>Greece</cop><pmid>21822540</pmid><doi>10.3892/mmr.2011.546</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Apolipoproteins E - genetics Body Mass Index Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetic Angiopathies - complications Diabetic Angiopathies - genetics Female Gene Frequency Genotype Humans Insulin Resistance Male Medicine, Chinese Traditional Middle Aged Polymorphism, Genetic Protein Isoforms - genetics Syndrome Yang Deficiency - classification Yang Deficiency - complications Yang Deficiency - genetics Yin Deficiency - classification Yin Deficiency - complications Yin Deficiency - genetics |
| title | Association of APOE polymorphisms and insulin resistance with TCM syndromes in type 2 diabetes patients with macroangiopathy |
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