In vitro and in vivo responses of advanced prostate tumors to PSMA ADC, an auristatin-conjugated antibody to prostate-specific membrane antigen

Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for therapy. PSMA ADC is an antibody-drug conjugate (ADC) that consists of a fully human anti-PSMA monoclonal antibody conjugated to monomethylauristati...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer therapeutics 2011-09, Vol.10 (9), p.1728-1739
Hauptverfasser:	Wang, Xinning, Ma, Dangshe, Olson, William C, Heston, Warren D W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminobenzoates - chemistry Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal - toxicity Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Antigens, Neoplasm - metabolism Antigens, Surface - immunology Antigens, Surface - metabolism Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Cell Line, Tumor Disease Models, Animal Glutamate Carboxypeptidase II - antagonists & inhibitors Glutamate Carboxypeptidase II - immunology Glutamate Carboxypeptidase II - metabolism Humans Immunoconjugates - pharmacology Immunoconjugates - therapeutic use Immunoconjugates - toxicity Kaplan-Meier Estimate Male Mice Mice, Nude Mutant Proteins - genetics Mutant Proteins - immunology Mutant Proteins - metabolism Neoplasm Staging Oligopeptides - chemistry Prostatic Neoplasms - drug therapy Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Tumor Burden - drug effects Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!