CD8+ cellular immunity mediates rAd5 vaccine protection against Ebola virus infection of nonhuman primates

Vaccines that protect nonhuman primates from lethal Ebola virus infection have been developed, but their protective mechanisms have not been clearly delineated. Nancy Sullivan et al . now report that the protective efficacy of a recombinant Ad5-based Ebola virus vaccine relies primarily on CD8 + T c...

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Veröffentlicht in:	Nature medicine 2011-09, Vol.17 (9), p.1128-1131
Hauptverfasser:	Sullivan, Nancy J, Hensley, Lisa, Asiedu, Clement, Geisbert, Thomas W, Stanley, Daphne, Johnson, Joshua, Honko, Anna, Olinger, Gene, Bailey, Michael, Geisbert, Joan B, Reimann, Keith A, Bao, Saran, Rao, Srinivas, Roederer, Mario, Jahrling, Peter B, Koup, Richard A, Nabel, Gary J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/2152/1566 631/326/596/2042 631/61/51/1868 692/699/255/2514 Adenoviridae - immunology Animals Antibodies, Monoclonal - immunology Antibodies, Viral - immunology Biomedical and Life Sciences Biomedicine Cancer Research CD3 Complex - immunology CD8-Positive T-Lymphocytes - immunology Cellular biology Ebola Vaccines - immunology Ebola virus Enzyme-Linked Immunosorbent Assay Female Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - prevention & control Immune system Immunohistochemistry Infectious Diseases letter Macaca fascicularis Metabolic Diseases Molecular Medicine Monkeys & apes Neurosciences Reverse Transcriptase Polymerase Chain Reaction Vaccines Viral Envelope Proteins - immunology
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