Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells

In chronic lymphocytic leukemia (CLL) the proliferation rate and resistance to drug-induced apoptosis are recognized as important factors in the outcome of treatment. In this study, we assess the activity and the mechanism of action of the prototype cell division cycle kinase 7 (Cdc7) inhibitor, PHA...

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Veröffentlicht in:	Molecular cancer therapeutics 2011-09, Vol.10 (9), p.1624-1634
Hauptverfasser:	Natoni, Alessandro, Murillo, Laura S, Kliszczak, Anna E, Catherwood, Mark A, Montagnoli, Alessia, Samali, Afshin, O'Dwyer, Michael, Santocanale, Corrado
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Caspases - metabolism CD40 Ligand - metabolism Cell Cycle - drug effects Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cells, Cultured Cyclin-Dependent Kinase 9 - antagonists & inhibitors Cyclin-Dependent Kinase 9 - metabolism DNA Replication - drug effects Gene Expression Regulation, Leukemic - drug effects Humans Interleukin-4 - pharmacology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Mice Myeloid Cell Leukemia Sequence 1 Protein NIH 3T3 Cells Phosphorylation - drug effects Piperidones - pharmacology Protein Kinase Inhibitors - pharmacology Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrroles - pharmacology RNA Polymerase II - metabolism Signal Transduction - drug effects
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