Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter

Objectives We aimed to investigate effects of the proton pump inhibitors (PPIs) omeprazole, lansoprazole and pantoprazole, which are currently used for the treatment of hyperacidity and gastro‐oesophageal reflux, on the reactivity of the isolated rat lower oesophageal sphincter. Methods Omeprazole...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2011-10, Vol.63 (10), p.1295-1300
Hauptverfasser:	Yurtsever, A. Sencer, Pektas, Mehtap, Ozkur, Mehtap, Un, Ismail, Erenmemisoglu, Aydın, Buyukafsar, Kansu
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology Angiotensins Animals Carbachol - pharmacology Electric Stimulation Esophageal Sphincter, Lower - drug effects Esophageal Sphincter, Lower - physiology gastro-oesophageal reflux Gastroesophageal Reflux Lansoprazole lower oesophageal sphincter Muscle Relaxation - drug effects Muscle, Smooth - drug effects omeprazole Omeprazole - pharmacology pantoprazole Proton Pump Inhibitors - pharmacology Rats Rats, Wistar
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container_title	Journal of pharmacy and pharmacology
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creator	Yurtsever, A. Sencer Pektas, Mehtap Ozkur, Mehtap Un, Ismail Erenmemisoglu, Aydın Buyukafsar, Kansu
description	Objectives We aimed to investigate effects of the proton pump inhibitors (PPIs) omeprazole, lansoprazole and pantoprazole, which are currently used for the treatment of hyperacidity and gastro‐oesophageal reflux, on the reactivity of the isolated rat lower oesophageal sphincter. Methods Omeprazole, lansoprazole and pantoprazole (all 10–9–10–3m, cumulatively) were tested on carbachol‐induced (10–6m) contraction. In addition, the effects of PPI preincubation (all 10–3m) on the contractions induced by cumulative carbachol (10−9–10−5m), angiotensin‐2 (10−9–10–5m) or electrical field stimulation (EFS; 40 V, 32 Hz, 1 ms, 10 s) were assessed. Finally, the effects of PPI on the spontaneous contractile activity of the tissue were also evaluated. Key findings PPI relaxed precontracted lower oesophageal sphincter in a concentration‐dependent manner and suppressed carbachol‐, angiotensin‐ and EFS‐induced contractions. Furthermore, PPI attenuated spontaneous contractile activity of the tissue. Conclusions Omeprazole, lansoprazole and pantoprazole had a suppressor effect on lower oesophageal sphincter contractions.
doi_str_mv	10.1111/j.2042-7158.2011.01333.x
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Sencer ; Pektas, Mehtap ; Ozkur, Mehtap ; Un, Ismail ; Erenmemisoglu, Aydın ; Buyukafsar, Kansu</creator><creatorcontrib>Yurtsever, A. Sencer ; Pektas, Mehtap ; Ozkur, Mehtap ; Un, Ismail ; Erenmemisoglu, Aydın ; Buyukafsar, Kansu</creatorcontrib><description>Objectives We aimed to investigate effects of the proton pump inhibitors (PPIs) omeprazole, lansoprazole and pantoprazole, which are currently used for the treatment of hyperacidity and gastro‐oesophageal reflux, on the reactivity of the isolated rat lower oesophageal sphincter. Methods Omeprazole, lansoprazole and pantoprazole (all 10–9–10–3m, cumulatively) were tested on carbachol‐induced (10–6m) contraction. In addition, the effects of PPI preincubation (all 10–3m) on the contractions induced by cumulative carbachol (10−9–10−5m), angiotensin‐2 (10−9–10–5m) or electrical field stimulation (EFS; 40 V, 32 Hz, 1 ms, 10 s) were assessed. Finally, the effects of PPI on the spontaneous contractile activity of the tissue were also evaluated. Key findings PPI relaxed precontracted lower oesophageal sphincter in a concentration‐dependent manner and suppressed carbachol‐, angiotensin‐ and EFS‐induced contractions. Furthermore, PPI attenuated spontaneous contractile activity of the tissue. Conclusions Omeprazole, lansoprazole and pantoprazole had a suppressor effect on lower oesophageal sphincter contractions.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/j.2042-7158.2011.01333.x</identifier><identifier>PMID: 21899545</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology ; Angiotensins ; Animals ; Carbachol - pharmacology ; Electric Stimulation ; Esophageal Sphincter, Lower - drug effects ; Esophageal Sphincter, Lower - physiology ; gastro-oesophageal reflux ; Gastroesophageal Reflux ; Lansoprazole ; lower oesophageal sphincter ; Muscle Relaxation - drug effects ; Muscle, Smooth - drug effects ; omeprazole ; Omeprazole - pharmacology ; pantoprazole ; Proton Pump Inhibitors - pharmacology ; Rats ; Rats, Wistar</subject><ispartof>Journal of pharmacy and pharmacology, 2011-10, Vol.63 (10), p.1295-1300</ispartof><rights>2011 The Authors. 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Sencer</creatorcontrib><creatorcontrib>Pektas, Mehtap</creatorcontrib><creatorcontrib>Ozkur, Mehtap</creatorcontrib><creatorcontrib>Un, Ismail</creatorcontrib><creatorcontrib>Erenmemisoglu, Aydın</creatorcontrib><creatorcontrib>Buyukafsar, Kansu</creatorcontrib><title>Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Objectives We aimed to investigate effects of the proton pump inhibitors (PPIs) omeprazole, lansoprazole and pantoprazole, which are currently used for the treatment of hyperacidity and gastro‐oesophageal reflux, on the reactivity of the isolated rat lower oesophageal sphincter. Methods Omeprazole, lansoprazole and pantoprazole (all 10–9–10–3m, cumulatively) were tested on carbachol‐induced (10–6m) contraction. In addition, the effects of PPI preincubation (all 10–3m) on the contractions induced by cumulative carbachol (10−9–10−5m), angiotensin‐2 (10−9–10–5m) or electrical field stimulation (EFS; 40 V, 32 Hz, 1 ms, 10 s) were assessed. Finally, the effects of PPI on the spontaneous contractile activity of the tissue were also evaluated. Key findings PPI relaxed precontracted lower oesophageal sphincter in a concentration‐dependent manner and suppressed carbachol‐, angiotensin‐ and EFS‐induced contractions. Furthermore, PPI attenuated spontaneous contractile activity of the tissue. Conclusions Omeprazole, lansoprazole and pantoprazole had a suppressor effect on lower oesophageal sphincter contractions.</description><subject>2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology</subject><subject>Angiotensins</subject><subject>Animals</subject><subject>Carbachol - pharmacology</subject><subject>Electric Stimulation</subject><subject>Esophageal Sphincter, Lower - drug effects</subject><subject>Esophageal Sphincter, Lower - physiology</subject><subject>gastro-oesophageal reflux</subject><subject>Gastroesophageal Reflux</subject><subject>Lansoprazole</subject><subject>lower oesophageal sphincter</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>omeprazole</subject><subject>Omeprazole - pharmacology</subject><subject>pantoprazole</subject><subject>Proton Pump Inhibitors - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1v2yAUhtHUac3a_YWJu93UKR82JjeVpn5X1Rqpm7Y7hPHJQmYbF7Ca7NcXN2muyw3nHN73BR6EMCVTmtbpaspIzrKSFjJVlE4J5ZxP1x_QZH9wgCaEMJbxouSH6HMIK0JIKYT4hA4ZlbNZkRcTtJl7F12H-6Htse2WtrLR-YBdC73X_10DJ7jRXXC7Duuuxr3u4n5gu3owgD00eq2jTVm2w3GZJjrixj2Dxw6Sf6n_gm5w6Je2MxH8Mfq40E2AL7v9CP26uvx5fpPdP1zfnn-_z0yeXp4ZU1clLwknUFOtF5JAURmRm6IQQnJCpWFC0jqvK8HkjDEiK8OhhFKwilcLfoS-bXN7754GCFG1Nhho0q_ADUFJKTlPVpaUcqs03oXgYaF6b1vtN4oSNXJXKzXiVSNeNXJXr9zVOlm_7i4ZqhbqvfENdBKcbQXPtoHNu4PV3fxmPpYpINsG2BBhvQ_Q_p8SiU-hfv-4VuJCPjL5-Edd8Bdy16N0</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Yurtsever, A. 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Sencer</creatorcontrib><creatorcontrib>Pektas, Mehtap</creatorcontrib><creatorcontrib>Ozkur, Mehtap</creatorcontrib><creatorcontrib>Un, Ismail</creatorcontrib><creatorcontrib>Erenmemisoglu, Aydın</creatorcontrib><creatorcontrib>Buyukafsar, Kansu</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yurtsever, A. Sencer</au><au>Pektas, Mehtap</au><au>Ozkur, Mehtap</au><au>Un, Ismail</au><au>Erenmemisoglu, Aydın</au><au>Buyukafsar, Kansu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>63</volume><issue>10</issue><spage>1295</spage><epage>1300</epage><pages>1295-1300</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Objectives We aimed to investigate effects of the proton pump inhibitors (PPIs) omeprazole, lansoprazole and pantoprazole, which are currently used for the treatment of hyperacidity and gastro‐oesophageal reflux, on the reactivity of the isolated rat lower oesophageal sphincter. Methods Omeprazole, lansoprazole and pantoprazole (all 10–9–10–3m, cumulatively) were tested on carbachol‐induced (10–6m) contraction. In addition, the effects of PPI preincubation (all 10–3m) on the contractions induced by cumulative carbachol (10−9–10−5m), angiotensin‐2 (10−9–10–5m) or electrical field stimulation (EFS; 40 V, 32 Hz, 1 ms, 10 s) were assessed. Finally, the effects of PPI on the spontaneous contractile activity of the tissue were also evaluated. Key findings PPI relaxed precontracted lower oesophageal sphincter in a concentration‐dependent manner and suppressed carbachol‐, angiotensin‐ and EFS‐induced contractions. Furthermore, PPI attenuated spontaneous contractile activity of the tissue. Conclusions Omeprazole, lansoprazole and pantoprazole had a suppressor effect on lower oesophageal sphincter contractions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21899545</pmid><doi>10.1111/j.2042-7158.2011.01333.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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source	Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects	2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology Angiotensins Animals Carbachol - pharmacology Electric Stimulation Esophageal Sphincter, Lower - drug effects Esophageal Sphincter, Lower - physiology gastro-oesophageal reflux Gastroesophageal Reflux Lansoprazole lower oesophageal sphincter Muscle Relaxation - drug effects Muscle, Smooth - drug effects omeprazole Omeprazole - pharmacology pantoprazole Proton Pump Inhibitors - pharmacology Rats Rats, Wistar
title	Proton pump inhibitors omeprazole, lansoprazole and pantoprazole induce relaxation in the rat lower oesophageal sphincter
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