Role of H4 receptor in histamine-mediated responses in human melanoma

We have previously reported that histamine at micromolar concentrations reduces the proliferation of melanoma cell lines. It is also known that melanoma cells express histamine H1, H2, and H3 receptors. The aim of this study was to investigate the presence of histamine H4 receptor (H4R) in human mel...

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Veröffentlicht in:	Melanoma research 2011-10, Vol.21 (5), p.395-404
Hauptverfasser:	Massari, Noelia A, Medina, Vanina A, Martinel Lamas, Diego J, Cricco, Graciela P, Croci, Máximo, Sambuco, Lorena, Bergoc, Rosa M, Rivera, Elena S
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation - physiology Cell Growth Processes - physiology Cell Line, Tumor Guanidines - pharmacology Histamine - metabolism Histamine - pharmacology Humans Imidazoles - pharmacology Immunohistochemistry Indoles - pharmacology Melanoma - genetics Melanoma - metabolism Melanoma - pathology Piperazines - pharmacology Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - biosynthesis Receptors, G-Protein-Coupled - genetics Receptors, Histamine - biosynthesis Receptors, Histamine - genetics Receptors, Histamine H4 RNA, Messenger - biosynthesis RNA, Messenger - genetics Skin Neoplasms - metabolism Thiourea - analogs & derivatives Thiourea - pharmacology
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