Serum matrix metalloproteinase-9 (MMP-9) as a biomarker for monitoring disease progression in Duchenne muscular dystrophy (DMD)

Abstract To identify serum biomarkers that allow monitoring of disease progression and treatment effects in Duchenne muscular dystrophy (DMD) patients, levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitors of metalloproteinase-1 (TIMP-1) and osteopontin (OPN) were determined in 63 DMD pati...

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Veröffentlicht in:	Neuromuscular disorders : NMD 2011-08, Vol.21 (8), p.569-578
Hauptverfasser:	Nadarajah, V.D, van Putten, M, Chaouch, A, Garrood, P, Straub, V, Lochmüller, H, Ginjaar, H.B, Aartsma-Rus, A.M, van Ommen, G.J.B, den Dunnen, J.T, t Hoen, P.A.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adrenal Cortex Hormones - therapeutic use Adult Animals Biomarkers - blood Case-Control Studies Child Child, Preschool Disease Models, Animal Disease Progression Duchenne muscular dystrophy Female Humans Longitudinal Studies Male Matrix Metalloproteinase 9 - blood Matrix metalloproteinase-9 mdx mouse Mice Mice, Inbred C57BL Mice, Inbred mdx Muscular Dystrophy, Duchenne - blood Muscular Dystrophy, Duchenne - drug therapy Muscular Dystrophy, Duchenne - physiopathology Neurology Osteopontin Osteopontin - blood Tissue Inhibitor of Metalloproteinase-1 - blood Tissue inhibitors of metalloproteinase-1 Treatment Outcome Young Adult
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