Preclinical evaluation of a new bombesin analog for imaging of gastrin-releasing peptide receptors

Bombesin (BBN) is a peptide showing high affinity for the gastrin-releasing peptide receptor. Tumors such as prostate, small cell lung cancer, breast, gastric, and colon cancer are known to over express receptors to BBN and gastrin-releasing peptide (GRP). The goal of this study was to evaluate a ne...

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Veröffentlicht in:	Cancer biotherapy & radiopharmaceuticals 2011-06, Vol.26 (3), p.309-316
Hauptverfasser:	Shirmardi, Seyed Pezhman, Gandomkar, Mostafa, Maragheh, Mohammad Ghannadi, Shamsaei, Mojtaba
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bombesin Bombesin - analogs & derivatives Cell Line, Tumor Cell receptors Chelating Agents - pharmacology Chromatography, High Pressure Liquid - methods Development and progression Drug Evaluation, Preclinical - methods gamma-Aminobutyric Acid - chemistry Gastrin Gastrin-Releasing Peptide - metabolism Gene Expression Regulation, Neoplastic Heterocyclic Compounds, 1-Ring - pharmacology Humans Hydrogen-Ion Concentration Mice Mice, Inbred BALB C Mice, Nude Models, Chemical Neoplasms - metabolism Peptides - chemistry Physiological aspects Receptors, Bombesin - metabolism Tissue Distribution Tomography, Emission-Computed, Single-Photon - methods Tumors
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