Development and maturation in the nereidid polychaetes Platynereis dumerilii and Nereis succinea exposed to xenoestrogens
Few studies link biochemical, cellular and whole animal effects of toxic compounds with growth and reproductive output on invertebrate model organisms. Thus, we explore the effects of xenoestrogens on nereid worms. Larvae of Platynereis dumerilii exposed to estradiol (E2) ethynylestradiol (EE2) and...
Gespeichert in:
| Veröffentlicht in: | Comparative biochemistry and physiology. Toxicology & pharmacology 2011-09, Vol.154 (3), p.196-203 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 203 |
|---|---|
| container_issue | 3 |
| container_start_page | 196 |
| container_title | Comparative biochemistry and physiology. Toxicology & pharmacology |
| container_volume | 154 |
| creator | García-Alonso, J. Ayoola, J.A.O. Crompton, J. Rebscher, N. Hardege, J.D. |
| description | Few studies link biochemical, cellular and whole animal effects of toxic compounds with growth and reproductive output on invertebrate model organisms. Thus, we explore the effects of xenoestrogens on nereid worms. Larvae of Platynereis dumerilii exposed to estradiol (E2) ethynylestradiol (EE2) and nonyplhenol (NP) observing the effects on growth, primordial germ cell (PGC) proliferation and maturation. In addition, a single exposure study was performed with a 50days latency period on adult worms of Nereis succinea. Since reduced glutathione (GSH) is required in detoxification of NP and is the precursor of the spawning pheromone nereithione (CSSG) in N. succinea, we analysed how the estrogenic chemical NP affects GSH concentrations. PGC were not affected by exposure to E2 and EE2 from 24hpf to 6days. Chronic exposure of P. dumerilii with NP over the full life cycle did not influence segment proliferation. Mature females that developed, even at high concentrations, were able to spawn and successful fertilization occurred. However, at high NP levels no P. dumerilii males matured. A significant decline of GSH can be seen in N. succinea males upon treatment with NP, but not in females, indicating that females stabilize GSH levels even in stress situations. This study shows some results that link the foundation to causally integrate toxic exposure to xenoestrogens with development, growth and reproductive outputs in nereidid polychaetes. |
| doi_str_mv | 10.1016/j.cbpc.2011.05.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_888113899</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1532045611000962</els_id><sourcerecordid>888113899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-8c8ef23000859c0bf878990aabc8888620c8f18491cd9f9b6fa075cd8b0b9d893</originalsourceid><addsrcrecordid>eNp9kE9v1DAQxS1ERf_AF-AAvnFKOs7GWVviggoFpKpFgp4tx560XiV2sJ2q--3xNoUjvtjyvPdm5kfIWwY1A9ad72rTz6ZugLEaeA2wfUFOmNiKinVcvixvvmkqaHl3TE5T2gEAb1n3ihw3rGuLrTkh-8_4gGOYJ_SZam_ppPMSdXbBU-dpvkfqMaKzztI5jHtzrzFjoj9GnfdPlUTtMmF0o3NPAdfrZ1qMcR41xcc5JLQ0B_qIPmDKMdyhT6_J0aDHhG-e7zNye_nl18W36urm6_eLT1eVaRnLlTACh2ZTZhdcGuiHsp-UoHVvRDldA0YMTLSSGSsH2XeDhi03VvTQSyvk5ox8WHPnGH4vpb2aXDI4jtpjWJIqIYxtSmZRNqvSxJBSxEHN0U067hUDdSCudupAXB2IK-CqEC-md8_xSz-h_Wf5i7gI3q-CQQel76JL6vZnqXRlpZYDO_T9uCqwYHhwGFUyDr1B6yKarGxw_5vgD2WFnbE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>888113899</pqid></control><display><type>article</type><title>Development and maturation in the nereidid polychaetes Platynereis dumerilii and Nereis succinea exposed to xenoestrogens</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>García-Alonso, J. ; Ayoola, J.A.O. ; Crompton, J. ; Rebscher, N. ; Hardege, J.D.</creator><creatorcontrib>García-Alonso, J. ; Ayoola, J.A.O. ; Crompton, J. ; Rebscher, N. ; Hardege, J.D.</creatorcontrib><description>Few studies link biochemical, cellular and whole animal effects of toxic compounds with growth and reproductive output on invertebrate model organisms. Thus, we explore the effects of xenoestrogens on nereid worms. Larvae of Platynereis dumerilii exposed to estradiol (E2) ethynylestradiol (EE2) and nonyplhenol (NP) observing the effects on growth, primordial germ cell (PGC) proliferation and maturation. In addition, a single exposure study was performed with a 50days latency period on adult worms of Nereis succinea. Since reduced glutathione (GSH) is required in detoxification of NP and is the precursor of the spawning pheromone nereithione (CSSG) in N. succinea, we analysed how the estrogenic chemical NP affects GSH concentrations. PGC were not affected by exposure to E2 and EE2 from 24hpf to 6days. Chronic exposure of P. dumerilii with NP over the full life cycle did not influence segment proliferation. Mature females that developed, even at high concentrations, were able to spawn and successful fertilization occurred. However, at high NP levels no P. dumerilii males matured. A significant decline of GSH can be seen in N. succinea males upon treatment with NP, but not in females, indicating that females stabilize GSH levels even in stress situations. This study shows some results that link the foundation to causally integrate toxic exposure to xenoestrogens with development, growth and reproductive outputs in nereidid polychaetes.</description><identifier>ISSN: 1532-0456</identifier><identifier>EISSN: 1878-1659</identifier><identifier>DOI: 10.1016/j.cbpc.2011.05.007</identifier><identifier>PMID: 21642012</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>adults ; Animals ; Cell Proliferation - drug effects ; chronic exposure ; Cysteine - analogs & derivatives ; Cysteine - metabolism ; Dose-Response Relationship, Drug ; Environmental Exposure ; estradiol ; Estradiol - toxicity ; Estrogens - toxicity ; Ethinyl Estradiol - toxicity ; Female ; females ; germ cells ; Germ Cells - drug effects ; glutathione ; Glutathione - analogs & derivatives ; Glutathione - metabolism ; GSH ; Inactivation, Metabolic ; invertebrates ; Larva - drug effects ; larvae ; Male ; males ; Marine ; Nereididae ; Nereis succinea ; Nonylphenol ; Phenols - toxicity ; pheromones ; Platynereis dumerilii ; Polychaeta ; Polychaeta - drug effects ; Polychaeta - growth & development ; Polychaeta - metabolism ; Reproduction ; Reproduction - drug effects ; reproductive performance ; Sex Ratio ; spawning ; Succinea ; toxicity ; Xenobiotics - toxicity ; Xenoestrogens</subject><ispartof>Comparative biochemistry and physiology. Toxicology & pharmacology, 2011-09, Vol.154 (3), p.196-203</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-8c8ef23000859c0bf878990aabc8888620c8f18491cd9f9b6fa075cd8b0b9d893</citedby><cites>FETCH-LOGICAL-c411t-8c8ef23000859c0bf878990aabc8888620c8f18491cd9f9b6fa075cd8b0b9d893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpc.2011.05.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27913,27914,45984</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21642012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Alonso, J.</creatorcontrib><creatorcontrib>Ayoola, J.A.O.</creatorcontrib><creatorcontrib>Crompton, J.</creatorcontrib><creatorcontrib>Rebscher, N.</creatorcontrib><creatorcontrib>Hardege, J.D.</creatorcontrib><title>Development and maturation in the nereidid polychaetes Platynereis dumerilii and Nereis succinea exposed to xenoestrogens</title><title>Comparative biochemistry and physiology. Toxicology & pharmacology</title><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><description>Few studies link biochemical, cellular and whole animal effects of toxic compounds with growth and reproductive output on invertebrate model organisms. Thus, we explore the effects of xenoestrogens on nereid worms. Larvae of Platynereis dumerilii exposed to estradiol (E2) ethynylestradiol (EE2) and nonyplhenol (NP) observing the effects on growth, primordial germ cell (PGC) proliferation and maturation. In addition, a single exposure study was performed with a 50days latency period on adult worms of Nereis succinea. Since reduced glutathione (GSH) is required in detoxification of NP and is the precursor of the spawning pheromone nereithione (CSSG) in N. succinea, we analysed how the estrogenic chemical NP affects GSH concentrations. PGC were not affected by exposure to E2 and EE2 from 24hpf to 6days. Chronic exposure of P. dumerilii with NP over the full life cycle did not influence segment proliferation. Mature females that developed, even at high concentrations, were able to spawn and successful fertilization occurred. However, at high NP levels no P. dumerilii males matured. A significant decline of GSH can be seen in N. succinea males upon treatment with NP, but not in females, indicating that females stabilize GSH levels even in stress situations. This study shows some results that link the foundation to causally integrate toxic exposure to xenoestrogens with development, growth and reproductive outputs in nereidid polychaetes.</description><subject>adults</subject><subject>Animals</subject><subject>Cell Proliferation - drug effects</subject><subject>chronic exposure</subject><subject>Cysteine - analogs & derivatives</subject><subject>Cysteine - metabolism</subject><subject>Dose-Response Relationship, Drug</subject><subject>Environmental Exposure</subject><subject>estradiol</subject><subject>Estradiol - toxicity</subject><subject>Estrogens - toxicity</subject><subject>Ethinyl Estradiol - toxicity</subject><subject>Female</subject><subject>females</subject><subject>germ cells</subject><subject>Germ Cells - drug effects</subject><subject>glutathione</subject><subject>Glutathione - analogs & derivatives</subject><subject>Glutathione - metabolism</subject><subject>GSH</subject><subject>Inactivation, Metabolic</subject><subject>invertebrates</subject><subject>Larva - drug effects</subject><subject>larvae</subject><subject>Male</subject><subject>males</subject><subject>Marine</subject><subject>Nereididae</subject><subject>Nereis succinea</subject><subject>Nonylphenol</subject><subject>Phenols - toxicity</subject><subject>pheromones</subject><subject>Platynereis dumerilii</subject><subject>Polychaeta</subject><subject>Polychaeta - drug effects</subject><subject>Polychaeta - growth & development</subject><subject>Polychaeta - metabolism</subject><subject>Reproduction</subject><subject>Reproduction - drug effects</subject><subject>reproductive performance</subject><subject>Sex Ratio</subject><subject>spawning</subject><subject>Succinea</subject><subject>toxicity</subject><subject>Xenobiotics - toxicity</subject><subject>Xenoestrogens</subject><issn>1532-0456</issn><issn>1878-1659</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxS1ERf_AF-AAvnFKOs7GWVviggoFpKpFgp4tx560XiV2sJ2q--3xNoUjvtjyvPdm5kfIWwY1A9ad72rTz6ZugLEaeA2wfUFOmNiKinVcvixvvmkqaHl3TE5T2gEAb1n3ihw3rGuLrTkh-8_4gGOYJ_SZam_ppPMSdXbBU-dpvkfqMaKzztI5jHtzrzFjoj9GnfdPlUTtMmF0o3NPAdfrZ1qMcR41xcc5JLQ0B_qIPmDKMdyhT6_J0aDHhG-e7zNye_nl18W36urm6_eLT1eVaRnLlTACh2ZTZhdcGuiHsp-UoHVvRDldA0YMTLSSGSsH2XeDhi03VvTQSyvk5ox8WHPnGH4vpb2aXDI4jtpjWJIqIYxtSmZRNqvSxJBSxEHN0U067hUDdSCudupAXB2IK-CqEC-md8_xSz-h_Wf5i7gI3q-CQQel76JL6vZnqXRlpZYDO_T9uCqwYHhwGFUyDr1B6yKarGxw_5vgD2WFnbE</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>García-Alonso, J.</creator><creator>Ayoola, J.A.O.</creator><creator>Crompton, J.</creator><creator>Rebscher, N.</creator><creator>Hardege, J.D.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>P64</scope><scope>SOI</scope></search><sort><creationdate>20110901</creationdate><title>Development and maturation in the nereidid polychaetes Platynereis dumerilii and Nereis succinea exposed to xenoestrogens</title><author>García-Alonso, J. ; Ayoola, J.A.O. ; Crompton, J. ; Rebscher, N. ; Hardege, J.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-8c8ef23000859c0bf878990aabc8888620c8f18491cd9f9b6fa075cd8b0b9d893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>adults</topic><topic>Animals</topic><topic>Cell Proliferation - drug effects</topic><topic>chronic exposure</topic><topic>Cysteine - analogs & derivatives</topic><topic>Cysteine - metabolism</topic><topic>Dose-Response Relationship, Drug</topic><topic>Environmental Exposure</topic><topic>estradiol</topic><topic>Estradiol - toxicity</topic><topic>Estrogens - toxicity</topic><topic>Ethinyl Estradiol - toxicity</topic><topic>Female</topic><topic>females</topic><topic>germ cells</topic><topic>Germ Cells - drug effects</topic><topic>glutathione</topic><topic>Glutathione - analogs & derivatives</topic><topic>Glutathione - metabolism</topic><topic>GSH</topic><topic>Inactivation, Metabolic</topic><topic>invertebrates</topic><topic>Larva - drug effects</topic><topic>larvae</topic><topic>Male</topic><topic>males</topic><topic>Marine</topic><topic>Nereididae</topic><topic>Nereis succinea</topic><topic>Nonylphenol</topic><topic>Phenols - toxicity</topic><topic>pheromones</topic><topic>Platynereis dumerilii</topic><topic>Polychaeta</topic><topic>Polychaeta - drug effects</topic><topic>Polychaeta - growth & development</topic><topic>Polychaeta - metabolism</topic><topic>Reproduction</topic><topic>Reproduction - drug effects</topic><topic>reproductive performance</topic><topic>Sex Ratio</topic><topic>spawning</topic><topic>Succinea</topic><topic>toxicity</topic><topic>Xenobiotics - toxicity</topic><topic>Xenoestrogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Alonso, J.</creatorcontrib><creatorcontrib>Ayoola, J.A.O.</creatorcontrib><creatorcontrib>Crompton, J.</creatorcontrib><creatorcontrib>Rebscher, N.</creatorcontrib><creatorcontrib>Hardege, J.D.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Alonso, J.</au><au>Ayoola, J.A.O.</au><au>Crompton, J.</au><au>Rebscher, N.</au><au>Hardege, J.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development and maturation in the nereidid polychaetes Platynereis dumerilii and Nereis succinea exposed to xenoestrogens</atitle><jtitle>Comparative biochemistry and physiology. Toxicology & pharmacology</jtitle><addtitle>Comp Biochem Physiol C Toxicol Pharmacol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>154</volume><issue>3</issue><spage>196</spage><epage>203</epage><pages>196-203</pages><issn>1532-0456</issn><eissn>1878-1659</eissn><abstract>Few studies link biochemical, cellular and whole animal effects of toxic compounds with growth and reproductive output on invertebrate model organisms. Thus, we explore the effects of xenoestrogens on nereid worms. Larvae of Platynereis dumerilii exposed to estradiol (E2) ethynylestradiol (EE2) and nonyplhenol (NP) observing the effects on growth, primordial germ cell (PGC) proliferation and maturation. In addition, a single exposure study was performed with a 50days latency period on adult worms of Nereis succinea. Since reduced glutathione (GSH) is required in detoxification of NP and is the precursor of the spawning pheromone nereithione (CSSG) in N. succinea, we analysed how the estrogenic chemical NP affects GSH concentrations. PGC were not affected by exposure to E2 and EE2 from 24hpf to 6days. Chronic exposure of P. dumerilii with NP over the full life cycle did not influence segment proliferation. Mature females that developed, even at high concentrations, were able to spawn and successful fertilization occurred. However, at high NP levels no P. dumerilii males matured. A significant decline of GSH can be seen in N. succinea males upon treatment with NP, but not in females, indicating that females stabilize GSH levels even in stress situations. This study shows some results that link the foundation to causally integrate toxic exposure to xenoestrogens with development, growth and reproductive outputs in nereidid polychaetes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21642012</pmid><doi>10.1016/j.cbpc.2011.05.007</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1532-0456 |
| ispartof | Comparative biochemistry and physiology. Toxicology & pharmacology, 2011-09, Vol.154 (3), p.196-203 |
| issn | 1532-0456 1878-1659 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_888113899 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | adults Animals Cell Proliferation - drug effects chronic exposure Cysteine - analogs & derivatives Cysteine - metabolism Dose-Response Relationship, Drug Environmental Exposure estradiol Estradiol - toxicity Estrogens - toxicity Ethinyl Estradiol - toxicity Female females germ cells Germ Cells - drug effects glutathione Glutathione - analogs & derivatives Glutathione - metabolism GSH Inactivation, Metabolic invertebrates Larva - drug effects larvae Male males Marine Nereididae Nereis succinea Nonylphenol Phenols - toxicity pheromones Platynereis dumerilii Polychaeta Polychaeta - drug effects Polychaeta - growth & development Polychaeta - metabolism Reproduction Reproduction - drug effects reproductive performance Sex Ratio spawning Succinea toxicity Xenobiotics - toxicity Xenoestrogens |
| title | Development and maturation in the nereidid polychaetes Platynereis dumerilii and Nereis succinea exposed to xenoestrogens |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A07%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20and%20maturation%20in%20the%20nereidid%20polychaetes%20Platynereis%20dumerilii%20and%20Nereis%20succinea%20exposed%20to%20xenoestrogens&rft.jtitle=Comparative%20biochemistry%20and%20physiology.%20Toxicology%20&%20pharmacology&rft.au=Garc%C3%ADa-Alonso,%20J.&rft.date=2011-09-01&rft.volume=154&rft.issue=3&rft.spage=196&rft.epage=203&rft.pages=196-203&rft.issn=1532-0456&rft.eissn=1878-1659&rft_id=info:doi/10.1016/j.cbpc.2011.05.007&rft_dat=%3Cproquest_cross%3E888113899%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=888113899&rft_id=info:pmid/21642012&rft_els_id=S1532045611000962&rfr_iscdi=true |