Multistability in platelets and their response to gold nanoparticles
Abstract The nanoparticle (NP) response of platelets is shown to be critically dependent on extent of preactivation of platelets by an agonist like ADP. A transition from de-aggregatory to aggregatory state is triggered in the presence of gold NPs (AuNP) only in such critical conditions. Adhered and...
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| Veröffentlicht in: | Nanomedicine 2011-08, Vol.7 (4), p.376-384 |
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| creator | Deb, Suryyani, MSc Patra, Hirak K., MSc Lahiri, Prabir, PhD Dasgupta, Anjan Kr., PhD Chakrabarti, Kuntal, PhD Chaudhuri, Utpal, MD |
| description | Abstract The nanoparticle (NP) response of platelets is shown to be critically dependent on extent of preactivation of platelets by an agonist like ADP. A transition from de-aggregatory to aggregatory state is triggered in the presence of gold NPs (AuNP) only in such critical conditions. Adhered and suspended platelets respond differentially to NPs. Preactivation in the adhered state induced by shear force explains such observation. The NP effect is associated with enhanced release reaction, tyrosine phosphorylation and CD62P expression level. Unlike cancer cells, whose response is maximal when NP size is optimal (within the range 50 - 70 nm), the platelet response monotonically increases with reduction of the AuNP size. The uptake study, using quenching of quinacrine hydrochloride fluorescence by AuNP, indicates that accumulation 18 nm AuNP is several-fold higher than the 68 nm AuNP. It is further shown that AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs. From the Clinical Editor Platelet aggregation can be triggered in the presence of gold nanoparticles (AuNP). Platelet response monotonically increases with reduction of the AuNP size. AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs. |
| doi_str_mv | 10.1016/j.nano.2011.01.007 |
| format | Article |
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A transition from de-aggregatory to aggregatory state is triggered in the presence of gold NPs (AuNP) only in such critical conditions. Adhered and suspended platelets respond differentially to NPs. Preactivation in the adhered state induced by shear force explains such observation. The NP effect is associated with enhanced release reaction, tyrosine phosphorylation and CD62P expression level. Unlike cancer cells, whose response is maximal when NP size is optimal (within the range 50 - 70 nm), the platelet response monotonically increases with reduction of the AuNP size. The uptake study, using quenching of quinacrine hydrochloride fluorescence by AuNP, indicates that accumulation 18 nm AuNP is several-fold higher than the 68 nm AuNP. It is further shown that AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs. From the Clinical Editor Platelet aggregation can be triggered in the presence of gold nanoparticles (AuNP). Platelet response monotonically increases with reduction of the AuNP size. AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs.</description><identifier>ISSN: 1549-9634</identifier><identifier>EISSN: 1549-9642</identifier><identifier>DOI: 10.1016/j.nano.2011.01.007</identifier><identifier>PMID: 21310267</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Activation ; Adenosine Triphosphate - metabolism ; Adhesion ; Blood Platelets - drug effects ; Blood Platelets - metabolism ; Blood Platelets - ultrastructure ; Gold - chemistry ; Gold nanoparticle ; Granule release ; Humans ; Internal Medicine ; Metal Nanoparticles - administration & dosage ; Metal Nanoparticles - chemistry ; Microscopy, Electron, Scanning ; Multi-stability ; Nanosafety measure ; Phosphorylation - drug effects ; Platelet Aggregation - drug effects ; Thrombotic risk ; Tyrosine - metabolism</subject><ispartof>Nanomedicine, 2011-08, Vol.7 (4), p.376-384</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-7be4bb662c49da1b0f7e4419f58a5e1ae44c51e09f24648dddf4ff7bb8147ce13</citedby><cites>FETCH-LOGICAL-c442t-7be4bb662c49da1b0f7e4419f58a5e1ae44c51e09f24648dddf4ff7bb8147ce13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1549963411000116$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21310267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deb, Suryyani, MSc</creatorcontrib><creatorcontrib>Patra, Hirak K., MSc</creatorcontrib><creatorcontrib>Lahiri, Prabir, PhD</creatorcontrib><creatorcontrib>Dasgupta, Anjan Kr., PhD</creatorcontrib><creatorcontrib>Chakrabarti, Kuntal, PhD</creatorcontrib><creatorcontrib>Chaudhuri, Utpal, MD</creatorcontrib><title>Multistability in platelets and their response to gold nanoparticles</title><title>Nanomedicine</title><addtitle>Nanomedicine</addtitle><description>Abstract The nanoparticle (NP) response of platelets is shown to be critically dependent on extent of preactivation of platelets by an agonist like ADP. A transition from de-aggregatory to aggregatory state is triggered in the presence of gold NPs (AuNP) only in such critical conditions. Adhered and suspended platelets respond differentially to NPs. Preactivation in the adhered state induced by shear force explains such observation. The NP effect is associated with enhanced release reaction, tyrosine phosphorylation and CD62P expression level. Unlike cancer cells, whose response is maximal when NP size is optimal (within the range 50 - 70 nm), the platelet response monotonically increases with reduction of the AuNP size. The uptake study, using quenching of quinacrine hydrochloride fluorescence by AuNP, indicates that accumulation 18 nm AuNP is several-fold higher than the 68 nm AuNP. It is further shown that AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs. From the Clinical Editor Platelet aggregation can be triggered in the presence of gold nanoparticles (AuNP). Platelet response monotonically increases with reduction of the AuNP size. AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs.</description><subject>Activation</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Adhesion</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Platelets - metabolism</subject><subject>Blood Platelets - ultrastructure</subject><subject>Gold - chemistry</subject><subject>Gold nanoparticle</subject><subject>Granule release</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Metal Nanoparticles - administration & dosage</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Microscopy, Electron, Scanning</subject><subject>Multi-stability</subject><subject>Nanosafety measure</subject><subject>Phosphorylation - drug effects</subject><subject>Platelet Aggregation - drug effects</subject><subject>Thrombotic risk</subject><subject>Tyrosine - metabolism</subject><issn>1549-9634</issn><issn>1549-9642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1rHDEMNaElSdP-gRzK3HrareTxzgeEQEmTtpDSQ9Kz8dia1FuvPbU9hf339bBpDjkEBJLgvSfeE2PnCGsEbD5u1175sOaAuIZS0B6xU9yIftU3gr96mmtxwt6ktAWoW4D-mJ1wrBF4056yz99nl23KarDO5n1lfTU5lclRTpXypsq_yMYqUpqCT1TlUD0EZ6rl8qRittpRestej8olevfYz9jPm-v7q6-r2x9fvl19ul1pIXhetQOJYWgarkVvFA4wtiQE9uOmUxtCVRa9QYJ-5KIRnTFmFOPYDkOHotWE9Rn7cNCdYvgzU8pyZ5Mm55SnMCfZdR0i57wvSH5A6hhSijTKKdqdinuJIJfw5FYuFuQSnoRS0BbS-0f5ediReaL8T6sALg4AKib_WooyaUtek7GRdJYm2Jf1L5_RtbPeauV-057SNszRl_gkysQlyLvlfcv3EAGKTFP_AyvVlgo</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Deb, Suryyani, MSc</creator><creator>Patra, Hirak K., MSc</creator><creator>Lahiri, Prabir, PhD</creator><creator>Dasgupta, Anjan Kr., PhD</creator><creator>Chakrabarti, Kuntal, PhD</creator><creator>Chaudhuri, Utpal, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110801</creationdate><title>Multistability in platelets and their response to gold nanoparticles</title><author>Deb, Suryyani, MSc ; Patra, Hirak K., MSc ; Lahiri, Prabir, PhD ; Dasgupta, Anjan Kr., PhD ; Chakrabarti, Kuntal, PhD ; Chaudhuri, Utpal, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-7be4bb662c49da1b0f7e4419f58a5e1ae44c51e09f24648dddf4ff7bb8147ce13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Activation</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Adhesion</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Platelets - metabolism</topic><topic>Blood Platelets - ultrastructure</topic><topic>Gold - chemistry</topic><topic>Gold nanoparticle</topic><topic>Granule release</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Metal Nanoparticles - administration & dosage</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Microscopy, Electron, Scanning</topic><topic>Multi-stability</topic><topic>Nanosafety measure</topic><topic>Phosphorylation - drug effects</topic><topic>Platelet Aggregation - drug effects</topic><topic>Thrombotic risk</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deb, Suryyani, MSc</creatorcontrib><creatorcontrib>Patra, Hirak K., MSc</creatorcontrib><creatorcontrib>Lahiri, Prabir, PhD</creatorcontrib><creatorcontrib>Dasgupta, Anjan Kr., PhD</creatorcontrib><creatorcontrib>Chakrabarti, Kuntal, PhD</creatorcontrib><creatorcontrib>Chaudhuri, Utpal, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Nanomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deb, Suryyani, MSc</au><au>Patra, Hirak K., MSc</au><au>Lahiri, Prabir, PhD</au><au>Dasgupta, Anjan Kr., PhD</au><au>Chakrabarti, Kuntal, PhD</au><au>Chaudhuri, Utpal, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multistability in platelets and their response to gold nanoparticles</atitle><jtitle>Nanomedicine</jtitle><addtitle>Nanomedicine</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>7</volume><issue>4</issue><spage>376</spage><epage>384</epage><pages>376-384</pages><issn>1549-9634</issn><eissn>1549-9642</eissn><abstract>Abstract The nanoparticle (NP) response of platelets is shown to be critically dependent on extent of preactivation of platelets by an agonist like ADP. A transition from de-aggregatory to aggregatory state is triggered in the presence of gold NPs (AuNP) only in such critical conditions. Adhered and suspended platelets respond differentially to NPs. Preactivation in the adhered state induced by shear force explains such observation. The NP effect is associated with enhanced release reaction, tyrosine phosphorylation and CD62P expression level. Unlike cancer cells, whose response is maximal when NP size is optimal (within the range 50 - 70 nm), the platelet response monotonically increases with reduction of the AuNP size. The uptake study, using quenching of quinacrine hydrochloride fluorescence by AuNP, indicates that accumulation 18 nm AuNP is several-fold higher than the 68 nm AuNP. It is further shown that AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs. From the Clinical Editor Platelet aggregation can be triggered in the presence of gold nanoparticles (AuNP). Platelet response monotonically increases with reduction of the AuNP size. AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21310267</pmid><doi>10.1016/j.nano.2011.01.007</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Activation Adenosine Triphosphate - metabolism Adhesion Blood Platelets - drug effects Blood Platelets - metabolism Blood Platelets - ultrastructure Gold - chemistry Gold nanoparticle Granule release Humans Internal Medicine Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Microscopy, Electron, Scanning Multi-stability Nanosafety measure Phosphorylation - drug effects Platelet Aggregation - drug effects Thrombotic risk Tyrosine - metabolism |
| title | Multistability in platelets and their response to gold nanoparticles |
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