The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions
Besiroglu L, Sozen M, Ozbebit Ö, Avcu S, Selvi Y, Bora A, Atli A, Unal O, Bulut MD. The involvement of distinct neural systems in patients with obsessive–compulsive disorder (OCD) with autogenous and reactive obsessions. Objective: To investigate the regional metabolite abnormalities and changes af...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2011-08, Vol.124 (2), p.141-151 |
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| creator | Besiroglu, L. Sozen, M. Ozbebit, Ö. Avcu, S. Selvi, Y. Bora, A. Atli, A. Unal, O. Bulut, M. D. |
| description | Besiroglu L, Sozen M, Ozbebit Ö, Avcu S, Selvi Y, Bora A, Atli A, Unal O, Bulut MD. The involvement of distinct neural systems in patients with obsessive–compulsive disorder (OCD) with autogenous and reactive obsessions.
Objective: To investigate the regional metabolite abnormalities and changes after treatment in patients with OCD with autogenous and reactive obsessions.
Method: We assessed right anterior cingulate cortex (ACC) and amygdala–hippocampal region (Am + Hpp) N‐acetyl‐aspartate (NAA), choline (Cho) and creatine (Cr) concentrations and NAA/Cr and Cho/Cr ratios using single‐voxel proton magnetic resonance spectroscopy in 15 patients with autogenous obsessions (OCD‐A), 15 patients with reactive obsessions (OCD‐R) and 15 healthy controls (HC). Measurements were repeated after 16 weeks of fluoxetine treatment.
Results: Baseline ACC NAA/Cr ratios of both OCD groups were significantly lower than HC. OCD‐A group had significantly lower baseline NAA/Cr ratios in the Am + Hpp than other groups. These differences were more likely to be explained by higher Cr levels in ACC. We found no significant differences and changes for Cho levels and Cho/Cr ratios between groups and within groups. Significant increase in NAA/Cr ratios of OCD‐A group found in the Am + Hpp was more likely to be explained by increased NAA levels. No significant changes were found in ACC NAA/Cr ratios.
Conclusion: While disturbed energy metabolism in ACC might reflect a common pathology in patients with OCD regardless of symptom dimension, alterations in mesiotemporal lobe are more likely for autogenous obsessions. |
| doi_str_mv | 10.1111/j.1600-0447.2011.01726.x |
| format | Article |
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Objective: To investigate the regional metabolite abnormalities and changes after treatment in patients with OCD with autogenous and reactive obsessions.
Method: We assessed right anterior cingulate cortex (ACC) and amygdala–hippocampal region (Am + Hpp) N‐acetyl‐aspartate (NAA), choline (Cho) and creatine (Cr) concentrations and NAA/Cr and Cho/Cr ratios using single‐voxel proton magnetic resonance spectroscopy in 15 patients with autogenous obsessions (OCD‐A), 15 patients with reactive obsessions (OCD‐R) and 15 healthy controls (HC). Measurements were repeated after 16 weeks of fluoxetine treatment.
Results: Baseline ACC NAA/Cr ratios of both OCD groups were significantly lower than HC. OCD‐A group had significantly lower baseline NAA/Cr ratios in the Am + Hpp than other groups. These differences were more likely to be explained by higher Cr levels in ACC. We found no significant differences and changes for Cho levels and Cho/Cr ratios between groups and within groups. Significant increase in NAA/Cr ratios of OCD‐A group found in the Am + Hpp was more likely to be explained by increased NAA levels. No significant changes were found in ACC NAA/Cr ratios.
Conclusion: While disturbed energy metabolism in ACC might reflect a common pathology in patients with OCD regardless of symptom dimension, alterations in mesiotemporal lobe are more likely for autogenous obsessions.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/j.1600-0447.2011.01726.x</identifier><identifier>PMID: 21627621</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Anxiety disorders. Neuroses ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biological and medical sciences ; Choline ; Choline - metabolism ; Cortex (cingulate) ; Creatine ; Creatine - metabolism ; Diagnostic and Statistical Manual of Mental Disorders ; Drug Monitoring - methods ; Energy metabolism ; Female ; Fluoxetine ; Fluoxetine - administration & dosage ; Fluoxetine - pharmacokinetics ; Humans ; limbic system ; Limbic System - drug effects ; Limbic System - metabolism ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Metabolites ; Middle Aged ; Neuropsychology ; Neuroses ; Obsessive Behavior - drug therapy ; Obsessive Behavior - metabolism ; Obsessive compulsive disorder ; Obsessive-Compulsive Disorder - drug therapy ; Obsessive-Compulsive Disorder - metabolism ; Obsessive-Compulsive Disorder - psychology ; Obsessive-compulsive disorders ; Pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; serotonin specific reuptake inhibitors ; Serotonin Uptake Inhibitors - administration & dosage ; Serotonin Uptake Inhibitors - pharmacokinetics ; subtypes ; Treatment Outcome</subject><ispartof>Acta psychiatrica Scandinavica, 2011-08, Vol.124 (2), p.141-151</ispartof><rights>2011 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2011 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4966-5fbbfa66db53d9db2113678946303313dbaa1bb63499d4be8580cbac8a7275243</citedby><cites>FETCH-LOGICAL-c4966-5fbbfa66db53d9db2113678946303313dbaa1bb63499d4be8580cbac8a7275243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.2011.01726.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.2011.01726.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24320705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21627621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Besiroglu, L.</creatorcontrib><creatorcontrib>Sozen, M.</creatorcontrib><creatorcontrib>Ozbebit, Ö.</creatorcontrib><creatorcontrib>Avcu, S.</creatorcontrib><creatorcontrib>Selvi, Y.</creatorcontrib><creatorcontrib>Bora, A.</creatorcontrib><creatorcontrib>Atli, A.</creatorcontrib><creatorcontrib>Unal, O.</creatorcontrib><creatorcontrib>Bulut, M. D.</creatorcontrib><title>The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Besiroglu L, Sozen M, Ozbebit Ö, Avcu S, Selvi Y, Bora A, Atli A, Unal O, Bulut MD. The involvement of distinct neural systems in patients with obsessive–compulsive disorder (OCD) with autogenous and reactive obsessions.
Objective: To investigate the regional metabolite abnormalities and changes after treatment in patients with OCD with autogenous and reactive obsessions.
Method: We assessed right anterior cingulate cortex (ACC) and amygdala–hippocampal region (Am + Hpp) N‐acetyl‐aspartate (NAA), choline (Cho) and creatine (Cr) concentrations and NAA/Cr and Cho/Cr ratios using single‐voxel proton magnetic resonance spectroscopy in 15 patients with autogenous obsessions (OCD‐A), 15 patients with reactive obsessions (OCD‐R) and 15 healthy controls (HC). Measurements were repeated after 16 weeks of fluoxetine treatment.
Results: Baseline ACC NAA/Cr ratios of both OCD groups were significantly lower than HC. OCD‐A group had significantly lower baseline NAA/Cr ratios in the Am + Hpp than other groups. These differences were more likely to be explained by higher Cr levels in ACC. We found no significant differences and changes for Cho levels and Cho/Cr ratios between groups and within groups. Significant increase in NAA/Cr ratios of OCD‐A group found in the Am + Hpp was more likely to be explained by increased NAA levels. No significant changes were found in ACC NAA/Cr ratios.
Conclusion: While disturbed energy metabolism in ACC might reflect a common pathology in patients with OCD regardless of symptom dimension, alterations in mesiotemporal lobe are more likely for autogenous obsessions.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anxiety disorders. Neuroses</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Choline</subject><subject>Choline - metabolism</subject><subject>Cortex (cingulate)</subject><subject>Creatine</subject><subject>Creatine - metabolism</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Drug Monitoring - methods</subject><subject>Energy metabolism</subject><subject>Female</subject><subject>Fluoxetine</subject><subject>Fluoxetine - administration & dosage</subject><subject>Fluoxetine - pharmacokinetics</subject><subject>Humans</subject><subject>limbic system</subject><subject>Limbic System - drug effects</subject><subject>Limbic System - metabolism</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Neuropsychology</subject><subject>Neuroses</subject><subject>Obsessive Behavior - drug therapy</subject><subject>Obsessive Behavior - metabolism</subject><subject>Obsessive compulsive disorder</subject><subject>Obsessive-Compulsive Disorder - drug therapy</subject><subject>Obsessive-Compulsive Disorder - metabolism</subject><subject>Obsessive-Compulsive Disorder - psychology</subject><subject>Obsessive-compulsive disorders</subject><subject>Pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>serotonin specific reuptake inhibitors</subject><subject>Serotonin Uptake Inhibitors - administration & dosage</subject><subject>Serotonin Uptake Inhibitors - pharmacokinetics</subject><subject>subtypes</subject><subject>Treatment Outcome</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl-P1CAUxYnRuLOrX8EQE-NTK5QW6IvJZqK7xvVPdNR9I0Cp27GFEdrZmUe_uWDHMfFFeeESfufkXg4AQIxyHNezdY4pQhkqS5YXCOMcYVbQfHcHLI4Xd8ECIYQzWqPrE3AawjoeK4z4fXBSYFowWuAF-LG6MbCzW9dvzWDsCF0Lmy6MndUjtGbysodhH0YzhIjBjRy7SAV424030KlgQui2JtNu2Ex9KpPa-cb4GZHT6L4a66YApW2gN1KPiTpInQ0PwL1W9sE8POxn4NPLF6vlZXb17uLV8vwq02VNaVa1SrWS0kZVpKkbVWBMKON1SQkiBJNGSYmVoqSs66ZUhlccaSU1l6xgVVGSM_B09t14930yYRRDF7Tpe2lNbE9wzuPT1rz6N8ko5pRSHsnHf5FrN3kbx4hQxQjjRYL4DGnvQvCmFRvfDdLvBUYixSnWIqUmUmoixSl-xSl2Ufro4D-pwTRH4e_8IvDkAMigZd96aXUX_nAlKRBDaaTnM3fb9Wb_3w2I8-X7j6mMBtlsEP-G2R0NpP8maJyzEl_eXojPb1bXH1bstWDkJ3IPzOo</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Besiroglu, L.</creator><creator>Sozen, M.</creator><creator>Ozbebit, Ö.</creator><creator>Avcu, S.</creator><creator>Selvi, Y.</creator><creator>Bora, A.</creator><creator>Atli, A.</creator><creator>Unal, O.</creator><creator>Bulut, M. D.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions</title><author>Besiroglu, L. ; Sozen, M. ; Ozbebit, Ö. ; Avcu, S. ; Selvi, Y. ; Bora, A. ; Atli, A. ; Unal, O. ; Bulut, M. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4966-5fbbfa66db53d9db2113678946303313dbaa1bb63499d4be8580cbac8a7275243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Anxiety disorders. Neuroses</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Choline</topic><topic>Choline - metabolism</topic><topic>Cortex (cingulate)</topic><topic>Creatine</topic><topic>Creatine - metabolism</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Drug Monitoring - methods</topic><topic>Energy metabolism</topic><topic>Female</topic><topic>Fluoxetine</topic><topic>Fluoxetine - administration & dosage</topic><topic>Fluoxetine - pharmacokinetics</topic><topic>Humans</topic><topic>limbic system</topic><topic>Limbic System - drug effects</topic><topic>Limbic System - metabolism</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Neuropsychology</topic><topic>Neuroses</topic><topic>Obsessive Behavior - drug therapy</topic><topic>Obsessive Behavior - metabolism</topic><topic>Obsessive compulsive disorder</topic><topic>Obsessive-Compulsive Disorder - drug therapy</topic><topic>Obsessive-Compulsive Disorder - metabolism</topic><topic>Obsessive-Compulsive Disorder - psychology</topic><topic>Obsessive-compulsive disorders</topic><topic>Pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>serotonin specific reuptake inhibitors</topic><topic>Serotonin Uptake Inhibitors - administration & dosage</topic><topic>Serotonin Uptake Inhibitors - pharmacokinetics</topic><topic>subtypes</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Besiroglu, L.</creatorcontrib><creatorcontrib>Sozen, M.</creatorcontrib><creatorcontrib>Ozbebit, Ö.</creatorcontrib><creatorcontrib>Avcu, S.</creatorcontrib><creatorcontrib>Selvi, Y.</creatorcontrib><creatorcontrib>Bora, A.</creatorcontrib><creatorcontrib>Atli, A.</creatorcontrib><creatorcontrib>Unal, O.</creatorcontrib><creatorcontrib>Bulut, M. D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Besiroglu, L.</au><au>Sozen, M.</au><au>Ozbebit, Ö.</au><au>Avcu, S.</au><au>Selvi, Y.</au><au>Bora, A.</au><au>Atli, A.</au><au>Unal, O.</au><au>Bulut, M. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2011-08</date><risdate>2011</risdate><volume>124</volume><issue>2</issue><spage>141</spage><epage>151</epage><pages>141-151</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Besiroglu L, Sozen M, Ozbebit Ö, Avcu S, Selvi Y, Bora A, Atli A, Unal O, Bulut MD. The involvement of distinct neural systems in patients with obsessive–compulsive disorder (OCD) with autogenous and reactive obsessions.
Objective: To investigate the regional metabolite abnormalities and changes after treatment in patients with OCD with autogenous and reactive obsessions.
Method: We assessed right anterior cingulate cortex (ACC) and amygdala–hippocampal region (Am + Hpp) N‐acetyl‐aspartate (NAA), choline (Cho) and creatine (Cr) concentrations and NAA/Cr and Cho/Cr ratios using single‐voxel proton magnetic resonance spectroscopy in 15 patients with autogenous obsessions (OCD‐A), 15 patients with reactive obsessions (OCD‐R) and 15 healthy controls (HC). Measurements were repeated after 16 weeks of fluoxetine treatment.
Results: Baseline ACC NAA/Cr ratios of both OCD groups were significantly lower than HC. OCD‐A group had significantly lower baseline NAA/Cr ratios in the Am + Hpp than other groups. These differences were more likely to be explained by higher Cr levels in ACC. We found no significant differences and changes for Cho levels and Cho/Cr ratios between groups and within groups. Significant increase in NAA/Cr ratios of OCD‐A group found in the Am + Hpp was more likely to be explained by increased NAA levels. No significant changes were found in ACC NAA/Cr ratios.
Conclusion: While disturbed energy metabolism in ACC might reflect a common pathology in patients with OCD regardless of symptom dimension, alterations in mesiotemporal lobe are more likely for autogenous obsessions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21627621</pmid><doi>10.1111/j.1600-0447.2011.01726.x</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Anxiety disorders. Neuroses Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Choline Choline - metabolism Cortex (cingulate) Creatine Creatine - metabolism Diagnostic and Statistical Manual of Mental Disorders Drug Monitoring - methods Energy metabolism Female Fluoxetine Fluoxetine - administration & dosage Fluoxetine - pharmacokinetics Humans limbic system Limbic System - drug effects Limbic System - metabolism Magnetic Resonance Spectroscopy Male Medical sciences Metabolites Middle Aged Neuropsychology Neuroses Obsessive Behavior - drug therapy Obsessive Behavior - metabolism Obsessive compulsive disorder Obsessive-Compulsive Disorder - drug therapy Obsessive-Compulsive Disorder - metabolism Obsessive-Compulsive Disorder - psychology Obsessive-compulsive disorders Pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry serotonin specific reuptake inhibitors Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - pharmacokinetics subtypes Treatment Outcome |
| title | The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions |
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