A time-dependent effect of caffeine upon lesion-induced plasticity
► Retinal lesions induce axonal sprouting of intact axons within superior colliculus. ► Caffeine treatment has opposite effects depending on the developmental time window. ► This drug may interfere with natural plasticity during brain development. ► Caffeine emerges as a facilitatory agent for neuro...
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| Veröffentlicht in: | Neuroscience research 2011-09, Vol.71 (1), p.99-102 |
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| creator | Cabral-Miranda, F. Serfaty, C.A. Campello-Costa, P. |
| description | ► Retinal lesions induce axonal sprouting of intact axons within superior colliculus. ► Caffeine treatment has opposite effects depending on the developmental time window. ► This drug may interfere with natural plasticity during brain development. ► Caffeine emerges as a facilitatory agent for neuronal plasticity in adulthood.
During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A
1 and A
2a antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30
mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window. |
| doi_str_mv | 10.1016/j.neures.2011.05.018 |
| format | Article |
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During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A
1 and A
2a antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30
mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window.</description><identifier>ISSN: 0168-0102</identifier><identifier>EISSN: 1872-8111</identifier><identifier>DOI: 10.1016/j.neures.2011.05.018</identifier><identifier>PMID: 21664389</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adenosine receptors ; Age Factors ; Animals ; Caffeine ; Caffeine - pharmacology ; Critical period ; Nerve Regeneration - drug effects ; Nerve Regeneration - physiology ; Neuronal Plasticity - drug effects ; Neuronal Plasticity - physiology ; Optic Nerve - drug effects ; Optic Nerve - physiopathology ; Optic Nerve Injuries - drug therapy ; Optic Nerve Injuries - physiopathology ; Plasticity ; Purinergic P1 Receptor Antagonists - pharmacology ; Rats ; Rats, Inbred Strains ; Retinal Ganglion Cells - drug effects ; Retinal Ganglion Cells - physiology ; Retinal lesion ; Time Factors ; Treatment Outcome</subject><ispartof>Neuroscience research, 2011-09, Vol.71 (1), p.99-102</ispartof><rights>2011 Elsevier Ireland Ltd and the Japan Neuroscience Society</rights><rights>Copyright © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-95db83427ab93899f8a529a8980d2c488d3f93bdf5481def25db2b8ec7ccfd493</citedby><cites>FETCH-LOGICAL-c417t-95db83427ab93899f8a529a8980d2c488d3f93bdf5481def25db2b8ec7ccfd493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21664389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cabral-Miranda, F.</creatorcontrib><creatorcontrib>Serfaty, C.A.</creatorcontrib><creatorcontrib>Campello-Costa, P.</creatorcontrib><title>A time-dependent effect of caffeine upon lesion-induced plasticity</title><title>Neuroscience research</title><addtitle>Neurosci Res</addtitle><description>► Retinal lesions induce axonal sprouting of intact axons within superior colliculus. ► Caffeine treatment has opposite effects depending on the developmental time window. ► This drug may interfere with natural plasticity during brain development. ► Caffeine emerges as a facilitatory agent for neuronal plasticity in adulthood.
During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A
1 and A
2a antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30
mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window.</description><subject>Adenosine receptors</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Caffeine</subject><subject>Caffeine - pharmacology</subject><subject>Critical period</subject><subject>Nerve Regeneration - drug effects</subject><subject>Nerve Regeneration - physiology</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Neuronal Plasticity - physiology</subject><subject>Optic Nerve - drug effects</subject><subject>Optic Nerve - physiopathology</subject><subject>Optic Nerve Injuries - drug therapy</subject><subject>Optic Nerve Injuries - physiopathology</subject><subject>Plasticity</subject><subject>Purinergic P1 Receptor Antagonists - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Retinal Ganglion Cells - drug effects</subject><subject>Retinal Ganglion Cells - physiology</subject><subject>Retinal lesion</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LxDAQhoMo7rr6D0R689SapO02uQjr4hcseNFzSJMJZGnTmrTC_ntTunoUTzOH552XeRC6JjgjmKzv9pmD0UPIKCYkw2WGCTtBS8IqmjJCyClaRoylmGC6QBch7DHGOS_yc7SgZL0ucsaX6GGTDLaFVEMPToMbEjAG1JB0JlEyrtZBMvadSxoItnOpdXpUoJO-kWGwyg6HS3RmZBPg6jhX6OPp8X37ku7enl-3m12qClINKS91zfKCVrLmsZobJkvKJeMMa6oKxnRueF5rUxaMaDA08rRmoCqljC54vkK3893ed58jhEG0NihoGumgG4NgbHqbcPoPEnNelWwii5lUvgvBgxG9t630B0GwmDSLvZg1i0mzwKWImmPs5lgw1i3o39CP1wjczwBEIV8WvAjKgovirI92he7s3w3fYdeQEQ</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Cabral-Miranda, F.</creator><creator>Serfaty, C.A.</creator><creator>Campello-Costa, P.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201109</creationdate><title>A time-dependent effect of caffeine upon lesion-induced plasticity</title><author>Cabral-Miranda, F. ; Serfaty, C.A. ; Campello-Costa, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-95db83427ab93899f8a529a8980d2c488d3f93bdf5481def25db2b8ec7ccfd493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenosine receptors</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Caffeine</topic><topic>Caffeine - pharmacology</topic><topic>Critical period</topic><topic>Nerve Regeneration - drug effects</topic><topic>Nerve Regeneration - physiology</topic><topic>Neuronal Plasticity - drug effects</topic><topic>Neuronal Plasticity - physiology</topic><topic>Optic Nerve - drug effects</topic><topic>Optic Nerve - physiopathology</topic><topic>Optic Nerve Injuries - drug therapy</topic><topic>Optic Nerve Injuries - physiopathology</topic><topic>Plasticity</topic><topic>Purinergic P1 Receptor Antagonists - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Retinal Ganglion Cells - drug effects</topic><topic>Retinal Ganglion Cells - physiology</topic><topic>Retinal lesion</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cabral-Miranda, F.</creatorcontrib><creatorcontrib>Serfaty, C.A.</creatorcontrib><creatorcontrib>Campello-Costa, P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cabral-Miranda, F.</au><au>Serfaty, C.A.</au><au>Campello-Costa, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A time-dependent effect of caffeine upon lesion-induced plasticity</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2011-09</date><risdate>2011</risdate><volume>71</volume><issue>1</issue><spage>99</spage><epage>102</epage><pages>99-102</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>► Retinal lesions induce axonal sprouting of intact axons within superior colliculus. ► Caffeine treatment has opposite effects depending on the developmental time window. ► This drug may interfere with natural plasticity during brain development. ► Caffeine emerges as a facilitatory agent for neuronal plasticity in adulthood.
During a critical period, unilateral retinal lesions induce rapid axonal sprouting of intact axons into denervated territories within the collicular visual layers. We investigated the effect of caffeine, a non-selective A
1 and A
2a antagonist, upon the lesion-induced plasticity of retinotectal axons. Pigmented rats submitted to a temporal retinal lesion received either caffeine (30
mg/kg, ip) or saline treatment. The anterograde tracing revealed that caffeine treatment during the critical period resulted in a clear reduction on the sprouting of ipsilateral fibers but to an amplification of the plasticity after PND21, thus revealing opposite effects depending on the developmental time window.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21664389</pmid><doi>10.1016/j.neures.2011.05.018</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Neuroscience research, 2011-09, Vol.71 (1), p.99-102 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenosine receptors Age Factors Animals Caffeine Caffeine - pharmacology Critical period Nerve Regeneration - drug effects Nerve Regeneration - physiology Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Optic Nerve - drug effects Optic Nerve - physiopathology Optic Nerve Injuries - drug therapy Optic Nerve Injuries - physiopathology Plasticity Purinergic P1 Receptor Antagonists - pharmacology Rats Rats, Inbred Strains Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - physiology Retinal lesion Time Factors Treatment Outcome |
| title | A time-dependent effect of caffeine upon lesion-induced plasticity |
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