Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease

► LPS in 6-OHDA-treated group induced spatial memory deficits in Y-maze and radial arm-maze tasks. ► LPS in 6-OHDA-treated group induced memory impairment and oxidative stress with relevance for Parkinson's disease. ► Behavioral deficits within Y-maze and radial arm-maze tasks are significantly...

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Veröffentlicht in:	Neuroscience research 2011-09, Vol.71 (1), p.35-43
Hauptverfasser:	Hritcu, Lucian, Ciobica, Alin, Stefan, Marius, Mihasan, Marius, Palamiuc, Lavinia, Nabeshima, Toshitaka
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Animals Cytokine Disease Models, Animal Lipopolysaccharide Lipopolysaccharides - toxicity Male Memory Memory Disorders - chemically induced Memory Disorders - metabolism Memory Disorders - physiopathology Microglia Neurotoxins - toxicity Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Oxidopamine - toxicity Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - metabolism Parkinsonian Disorders - physiopathology Rats Rats, Wistar
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