Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease
► LPS in 6-OHDA-treated group induced spatial memory deficits in Y-maze and radial arm-maze tasks. ► LPS in 6-OHDA-treated group induced memory impairment and oxidative stress with relevance for Parkinson's disease. ► Behavioral deficits within Y-maze and radial arm-maze tasks are significantly...
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| Veröffentlicht in: | Neuroscience research 2011-09, Vol.71 (1), p.35-43 |
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| creator | Hritcu, Lucian Ciobica, Alin Stefan, Marius Mihasan, Marius Palamiuc, Lavinia Nabeshima, Toshitaka |
| description | ► LPS in 6-OHDA-treated group induced spatial memory deficits in Y-maze and radial arm-maze tasks. ► LPS in 6-OHDA-treated group induced memory impairment and oxidative stress with relevance for Parkinson's disease. ► Behavioral deficits within Y-maze and radial arm-maze tasks are significantly correlated to oxidative stress generation.
Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250
μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2
μg/μl saline; 5
μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS
+
6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS
+
6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA. |
| doi_str_mv | 10.1016/j.neures.2011.05.016 |
| format | Article |
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Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250
μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2
μg/μl saline; 5
μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS
+
6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS
+
6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.</description><identifier>ISSN: 0168-0102</identifier><identifier>EISSN: 1872-8111</identifier><identifier>DOI: 10.1016/j.neures.2011.05.016</identifier><identifier>PMID: 21663772</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>6-Hydroxydopamine ; Animals ; Cytokine ; Disease Models, Animal ; Lipopolysaccharide ; Lipopolysaccharides - toxicity ; Male ; Memory ; Memory Disorders - chemically induced ; Memory Disorders - metabolism ; Memory Disorders - physiopathology ; Microglia ; Neurotoxins - toxicity ; Oxidative stress ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Oxidopamine - toxicity ; Parkinson's disease ; Parkinsonian Disorders - chemically induced ; Parkinsonian Disorders - metabolism ; Parkinsonian Disorders - physiopathology ; Rats ; Rats, Wistar</subject><ispartof>Neuroscience research, 2011-09, Vol.71 (1), p.35-43</ispartof><rights>2011 Elsevier Ireland Ltd and the Japan Neuroscience Society</rights><rights>Copyright © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-1f00c200f06a8c3c46ef98c60dd0dff1c8623a892f12f7261c6ac4a4a7884b343</citedby><cites>FETCH-LOGICAL-c483t-1f00c200f06a8c3c46ef98c60dd0dff1c8623a892f12f7261c6ac4a4a7884b343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21663772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hritcu, Lucian</creatorcontrib><creatorcontrib>Ciobica, Alin</creatorcontrib><creatorcontrib>Stefan, Marius</creatorcontrib><creatorcontrib>Mihasan, Marius</creatorcontrib><creatorcontrib>Palamiuc, Lavinia</creatorcontrib><creatorcontrib>Nabeshima, Toshitaka</creatorcontrib><title>Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease</title><title>Neuroscience research</title><addtitle>Neurosci Res</addtitle><description>► LPS in 6-OHDA-treated group induced spatial memory deficits in Y-maze and radial arm-maze tasks. ► LPS in 6-OHDA-treated group induced memory impairment and oxidative stress with relevance for Parkinson's disease. ► Behavioral deficits within Y-maze and radial arm-maze tasks are significantly correlated to oxidative stress generation.
Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250
μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2
μg/μl saline; 5
μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS
+
6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS
+
6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.</description><subject>6-Hydroxydopamine</subject><subject>Animals</subject><subject>Cytokine</subject><subject>Disease Models, Animal</subject><subject>Lipopolysaccharide</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Male</subject><subject>Memory</subject><subject>Memory Disorders - chemically induced</subject><subject>Memory Disorders - metabolism</subject><subject>Memory Disorders - physiopathology</subject><subject>Microglia</subject><subject>Neurotoxins - toxicity</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Oxidopamine - toxicity</subject><subject>Parkinson's disease</subject><subject>Parkinsonian Disorders - chemically induced</subject><subject>Parkinsonian Disorders - metabolism</subject><subject>Parkinsonian Disorders - physiopathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0168-0102</issn><issn>1872-8111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc-KFDEQxoMo7rj6BiK57anbStKTTl8EWfwHCwrqOWSTypoxnbRJz7rzAL63GWb1KJ4KvvpVfUV9hDxn0DNg8uWuT7gvWHsOjPWw7Zv4gGyYGnmnGGMPyaYpqgMG_Iw8qXUHAGIaxGNyxpmUYhz5hvz6vJg1mEhnnHM5UIc-2LBWapKj-S641r1FWtfmVKkzs7lB6nOM-WdINxTvllzbFXTNNIYlLzkeqrH2mynBIQ2JGlqyw7TSuZVIs6efTPkeUs3poi0MFU3Fp-SRN7His_t6Tr6-ffPl8n139fHdh8vXV50dlFg75gEsB_AgjbLCDhL9pKwE58B5z6ySXBg1cc-4H7lkVho7mMGMSg3XYhDn5OK0dyn5xx7rqudQLcZoEuZ91UodP8eU-A8SpmncjmMjhxNpS661oNdLCbMpB81AH5PSO31KSh-T0rDVTWxjL-4N9tczur9Df6JpwKsTgO0htwGLrjZgsuhCQbtql8O_HX4DjqWpQw</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Hritcu, Lucian</creator><creator>Ciobica, Alin</creator><creator>Stefan, Marius</creator><creator>Mihasan, Marius</creator><creator>Palamiuc, Lavinia</creator><creator>Nabeshima, Toshitaka</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201109</creationdate><title>Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease</title><author>Hritcu, Lucian ; Ciobica, Alin ; Stefan, Marius ; Mihasan, Marius ; Palamiuc, Lavinia ; Nabeshima, Toshitaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-1f00c200f06a8c3c46ef98c60dd0dff1c8623a892f12f7261c6ac4a4a7884b343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>6-Hydroxydopamine</topic><topic>Animals</topic><topic>Cytokine</topic><topic>Disease Models, Animal</topic><topic>Lipopolysaccharide</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Male</topic><topic>Memory</topic><topic>Memory Disorders - chemically induced</topic><topic>Memory Disorders - metabolism</topic><topic>Memory Disorders - physiopathology</topic><topic>Microglia</topic><topic>Neurotoxins - toxicity</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Oxidopamine - toxicity</topic><topic>Parkinson's disease</topic><topic>Parkinsonian Disorders - chemically induced</topic><topic>Parkinsonian Disorders - metabolism</topic><topic>Parkinsonian Disorders - physiopathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hritcu, Lucian</creatorcontrib><creatorcontrib>Ciobica, Alin</creatorcontrib><creatorcontrib>Stefan, Marius</creatorcontrib><creatorcontrib>Mihasan, Marius</creatorcontrib><creatorcontrib>Palamiuc, Lavinia</creatorcontrib><creatorcontrib>Nabeshima, Toshitaka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hritcu, Lucian</au><au>Ciobica, Alin</au><au>Stefan, Marius</au><au>Mihasan, Marius</au><au>Palamiuc, Lavinia</au><au>Nabeshima, Toshitaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease</atitle><jtitle>Neuroscience research</jtitle><addtitle>Neurosci Res</addtitle><date>2011-09</date><risdate>2011</risdate><volume>71</volume><issue>1</issue><spage>35</spage><epage>43</epage><pages>35-43</pages><issn>0168-0102</issn><eissn>1872-8111</eissn><abstract>► LPS in 6-OHDA-treated group induced spatial memory deficits in Y-maze and radial arm-maze tasks. ► LPS in 6-OHDA-treated group induced memory impairment and oxidative stress with relevance for Parkinson's disease. ► Behavioral deficits within Y-maze and radial arm-maze tasks are significantly correlated to oxidative stress generation.
Stimulation of the immune system has been found to enhance, impair, or have no effect on various memory tasks. In the present study, male Wistar rats received saline, lipopolysaccharide (LPS, 250
μg/kg in saline, 7 consecutive days), intranigral 6-hydroxydopamine (6-OHDA, 2
μg/μl saline; 5
μl/site) and intranigral 6-OHDA plus 7 consecutive days of LPS injections and then tested in two cognitive tasks (Y-maze and radial arm-maze). Altered behavioral responses in Y-maze and radial arm-maze tasks were observed in LPS- and LPS
+
6-OHDA-treated rats compared to control group. Notably, positive correlations were detected among LPS and LPS
+
6-OHDA-treated rats when behavioral deficits were correlated with indicators of oxidative stress. Taken together, we demonstrated that activation of the immune system with LPS administration induced memory impairment and brain oxidative stress, significantly correlated with nigral lesion promoted by 6-OHDA.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21663772</pmid><doi>10.1016/j.neures.2011.05.016</doi><tpages>9</tpages></addata></record> |
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| subjects | 6-Hydroxydopamine Animals Cytokine Disease Models, Animal Lipopolysaccharide Lipopolysaccharides - toxicity Male Memory Memory Disorders - chemically induced Memory Disorders - metabolism Memory Disorders - physiopathology Microglia Neurotoxins - toxicity Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Oxidopamine - toxicity Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - metabolism Parkinsonian Disorders - physiopathology Rats Rats, Wistar |
| title | Spatial memory deficits and oxidative stress damage following exposure to lipopolysaccharide in a rodent model of Parkinson's disease |
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