Generation of mice with a conditional and reporter allele for Tmem100

Activin receptor‐like kinase 1 (ACVRL1; ALK1) is predominantly expressed in arterial endothelial cells and plays an important role in angiogenesis. ACVRL1 mutations cause hereditary hemorrhagic telangiectasia (HHT), a genetic vascular disorder for which the underlying mechanism is poorly understood....

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Veröffentlicht in:	Genesis (New York, N.Y. : 2000) N.Y. : 2000), 2010-11, Vol.48 (11), p.673-678
Hauptverfasser:	Moon, Eun-Hye, Kim, Mi-Jung, Ko, Keum Soun, Kim, Yoo Sung, Seo, Jiyoung, Oh, S. Paul, Lee, Young Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type I - genetics Activin Receptors, Type I - physiology Acvrl1 Alleles Amino Acid Sequence angiogenesis Animals Cells, Cultured Embryo, Mammalian endothelial cells Endothelial Cells - metabolism Endothelial Cells - physiology Gene Transfer Techniques Genes, Reporter - physiology knockout Membrane Proteins - genetics Mice Mice, Transgenic Models, Biological Molecular Sequence Data Organ Specificity - genetics Sequence Homology, Amino Acid Tmem100 Transgenes - physiology Validation Studies as Topic
Online-Zugang:	Volltext
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