CTLA-4-Ig Therapy Diminishes the Frequency but Enhances the Function of Treg Cells in Patients with Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease. Natural T regulatory (nTreg) cells, which constitutively express the CTLA-4 molecule, have an important role in the pathogenesis of autoimmune conditions. Although it has been reported that biological agents are able to modulate th...

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Veröffentlicht in:	Journal of clinical immunology 2011-08, Vol.31 (4), p.588-595
Hauptverfasser:	Álvarez-Quiroga, Crisol, Abud-Mendoza, Carlos, Doníz-Padilla, Lesly, Juárez-Reyes, Amida, Monsiváis-Urenda, Adriana, Baranda, Lourdes, González-Amaro, Roberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Adolescent Adult Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Biomedical and Life Sciences Biomedicine CD4 Antigens - immunology Cell Proliferation Female Flow Cytometry Forkhead Transcription Factors - immunology Humans Immunoconjugates - administration & dosage Immunoconjugates - metabolism Immunoconjugates - therapeutic use Immunology Infectious Diseases Interleukin-2 Receptor alpha Subunit - immunology Internal Medicine Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - immunology Lymphocyte Activation - immunology Male Medical Microbiology Middle Aged T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology
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