Antibody expression kinetics in glycoengineered Pichia pastoris

Growth of the antibody market has fueled the development of alternative expression systems such as glycoengineered yeast. Although intact antibody expression levels in excess of 1 g L⁻¹ have been demonstrated in glycoengineered yeast, this is still significantly below the titers reported for antibod...

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Veröffentlicht in:	Biotechnology and bioengineering 2010-08, Vol.106 (6), p.918-927
Hauptverfasser:	Potgieter, Thomas I, Kersey, Sean D, Mallem, Muralidhar R, Nylen, Adam C, d'Anjou, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - genetics Antibodies - metabolism antibody Biochemistry Bioengineering Biological and medical sciences Biomass Biotechnology expression kinetics fed-batch cultivation Fermentation Fundamental and applied biological sciences. Psychology Gene Expression glycoengineering Glycosylation Health. Pharmaceutical industry Immune system Industrial applications and implications. Economical aspects Methanol - metabolism Monoclonal antibodies Oxygen - metabolism Pichia - genetics Pichia - metabolism Pichia pastoris Production of active biomolecules Protein Processing, Post-Translational Reaction kinetics Recombinant Proteins - genetics Recombinant Proteins - metabolism Yeast
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