Hypothalamic gray matter volume loss in hypnic headache
Objective Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the...
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| Veröffentlicht in: | Annals of neurology 2011-03, Vol.69 (3), p.533-539 |
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| container_title | Annals of neurology |
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| creator | Holle, Dagny Naegel, Steffen Krebs, Sarah Gaul, Charly Gizewski, Elke Diener, Hans-Christoph Katsarava, Zaza Obermann, Mark |
| description | Objective
Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the cerebral management center of sleep regulation and pain control.
Methods
Fourteen patients with HH and 14 age‐matched and gender‐matched healthy controls were investigated using magnetic resonance imaging–based voxel‐based morphometry.
Results
We detected gray matter volume decrease in the posterior hypothalamus of HH patients. Additional gray matter decrease was observed in brain areas known to be associated with cerebral pain processing, including the cingulate cortex, operculum, and frontal lobe, as well as in the temporal lobe.
Interpretation
Our data confirm the hypothesized involvement of the posterior hypothalamus in the pathophysiology of HH and emphasize the importance of this structure for sleep regulation and pain control. ANN NEUROL 2010 |
| doi_str_mv | 10.1002/ana.22188 |
| format | Article |
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Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the cerebral management center of sleep regulation and pain control.
Methods
Fourteen patients with HH and 14 age‐matched and gender‐matched healthy controls were investigated using magnetic resonance imaging–based voxel‐based morphometry.
Results
We detected gray matter volume decrease in the posterior hypothalamus of HH patients. Additional gray matter decrease was observed in brain areas known to be associated with cerebral pain processing, including the cingulate cortex, operculum, and frontal lobe, as well as in the temporal lobe.
Interpretation
Our data confirm the hypothesized involvement of the posterior hypothalamus in the pathophysiology of HH and emphasize the importance of this structure for sleep regulation and pain control. ANN NEUROL 2010</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.22188</identifier><identifier>PMID: 21446025</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Brain ; Female ; Headache Disorders, Primary - pathology ; Headaches ; Humans ; Hypothalamus - pathology ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Nerve Fibers, Unmyelinated - pathology ; Neurology ; Organ Size ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Annals of neurology, 2011-03, Vol.69 (3), p.533-539</ispartof><rights>Copyright © 2010 American Neurological Association</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 American Neurological Association.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4528-3f97aefc937b13f77370d945191ed11cc036e57f68f1954dc11cecaadab7927d3</citedby><cites>FETCH-LOGICAL-c4528-3f97aefc937b13f77370d945191ed11cc036e57f68f1954dc11cecaadab7927d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.22188$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.22188$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24028048$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21446025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holle, Dagny</creatorcontrib><creatorcontrib>Naegel, Steffen</creatorcontrib><creatorcontrib>Krebs, Sarah</creatorcontrib><creatorcontrib>Gaul, Charly</creatorcontrib><creatorcontrib>Gizewski, Elke</creatorcontrib><creatorcontrib>Diener, Hans-Christoph</creatorcontrib><creatorcontrib>Katsarava, Zaza</creatorcontrib><creatorcontrib>Obermann, Mark</creatorcontrib><title>Hypothalamic gray matter volume loss in hypnic headache</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Objective
Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the cerebral management center of sleep regulation and pain control.
Methods
Fourteen patients with HH and 14 age‐matched and gender‐matched healthy controls were investigated using magnetic resonance imaging–based voxel‐based morphometry.
Results
We detected gray matter volume decrease in the posterior hypothalamus of HH patients. Additional gray matter decrease was observed in brain areas known to be associated with cerebral pain processing, including the cingulate cortex, operculum, and frontal lobe, as well as in the temporal lobe.
Interpretation
Our data confirm the hypothesized involvement of the posterior hypothalamus in the pathophysiology of HH and emphasize the importance of this structure for sleep regulation and pain control. ANN NEUROL 2010</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Female</subject><subject>Headache Disorders, Primary - pathology</subject><subject>Headaches</subject><subject>Humans</subject><subject>Hypothalamus - pathology</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Fibers, Unmyelinated - pathology</subject><subject>Neurology</subject><subject>Organ Size</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHDEUhoO01HXbC_9AGShFejGak49JcrmIrgWxFCtehrOZTHfsfKzJTHX-fWN3tVAovQqE57zvOQ8hh0CPgVJ2gh0eMwZa75EZSA65ZsK8IjPKC5FL4GKfHMR4Ryk1BdA3ZJ-BEAVlckbUxbTphzU22NYu-x5wylocBh-yn30ztj5r-hizusvW06ZLxNpjiW7t35LXFTbRv9u9c3Jzfvbt9CK__LL8fLq4zJ2QTOe8Mgp95QxXK-CVUlzR0ggJBnwJ4Fxa0UtVFboCI0Xp0p93mDpWyjBV8jk52uZuQn8_-jjYto7ONw12vh-j1VoD1ZLq_5PScBA6rTAnH_4i7_oxdOkMC1xxxgqeLM7Jpy3lQlIQfGU3oW4xTBaofdJuk3b7W3ti3-8Sx1Xryxfy2XMCPu4AjA6bKmDn6viHE5RpKp6CTrbcQ9346d-NdnG1eK7OtxN1HPzjywSGH7ZItqW9vVpacW0Ep8tr-5X_AuIBpXE</recordid><startdate>201103</startdate><enddate>201103</enddate><creator>Holle, Dagny</creator><creator>Naegel, Steffen</creator><creator>Krebs, Sarah</creator><creator>Gaul, Charly</creator><creator>Gizewski, Elke</creator><creator>Diener, Hans-Christoph</creator><creator>Katsarava, Zaza</creator><creator>Obermann, Mark</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201103</creationdate><title>Hypothalamic gray matter volume loss in hypnic headache</title><author>Holle, Dagny ; Naegel, Steffen ; Krebs, Sarah ; Gaul, Charly ; Gizewski, Elke ; Diener, Hans-Christoph ; Katsarava, Zaza ; Obermann, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4528-3f97aefc937b13f77370d945191ed11cc036e57f68f1954dc11cecaadab7927d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Female</topic><topic>Headache Disorders, Primary - pathology</topic><topic>Headaches</topic><topic>Humans</topic><topic>Hypothalamus - pathology</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nerve Fibers, Unmyelinated - pathology</topic><topic>Neurology</topic><topic>Organ Size</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holle, Dagny</creatorcontrib><creatorcontrib>Naegel, Steffen</creatorcontrib><creatorcontrib>Krebs, Sarah</creatorcontrib><creatorcontrib>Gaul, Charly</creatorcontrib><creatorcontrib>Gizewski, Elke</creatorcontrib><creatorcontrib>Diener, Hans-Christoph</creatorcontrib><creatorcontrib>Katsarava, Zaza</creatorcontrib><creatorcontrib>Obermann, Mark</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holle, Dagny</au><au>Naegel, Steffen</au><au>Krebs, Sarah</au><au>Gaul, Charly</au><au>Gizewski, Elke</au><au>Diener, Hans-Christoph</au><au>Katsarava, Zaza</au><au>Obermann, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothalamic gray matter volume loss in hypnic headache</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>2011-03</date><risdate>2011</risdate><volume>69</volume><issue>3</issue><spage>533</spage><epage>539</epage><pages>533-539</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Objective
Hypnic headache (HH) is a rare primary headache disorder characterized by strictly nocturnal headache attacks that mostly occur at the same time at night. The pathophysiology of this disease is poorly understood, but hypothalamic involvement was suspected as the hypothalamus represents the cerebral management center of sleep regulation and pain control.
Methods
Fourteen patients with HH and 14 age‐matched and gender‐matched healthy controls were investigated using magnetic resonance imaging–based voxel‐based morphometry.
Results
We detected gray matter volume decrease in the posterior hypothalamus of HH patients. Additional gray matter decrease was observed in brain areas known to be associated with cerebral pain processing, including the cingulate cortex, operculum, and frontal lobe, as well as in the temporal lobe.
Interpretation
Our data confirm the hypothesized involvement of the posterior hypothalamus in the pathophysiology of HH and emphasize the importance of this structure for sleep regulation and pain control. ANN NEUROL 2010</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21446025</pmid><doi>10.1002/ana.22188</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biological and medical sciences Brain Female Headache Disorders, Primary - pathology Headaches Humans Hypothalamus - pathology Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical sciences Middle Aged Nerve Fibers, Unmyelinated - pathology Neurology Organ Size Vascular diseases and vascular malformations of the nervous system |
| title | Hypothalamic gray matter volume loss in hypnic headache |
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