Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor

Objective: Parkinson disease (PD) is characterized by striatal dopamine depletion, which explains clinical symptoms such as bradykinesia and rigidity, but not resting tremor. Instead, resting tremor is associated with increased activity in a distinct cerebellothalamic circuit. To date, it remains un...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of neurology 2011-02, Vol.69 (2), p.269-281
Hauptverfasser:	Helmich, Rick C., Janssen, Marcel J. R., Oyen, Wim J. G., Bloem, Bastiaan R., Toni, Ivan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Basal Ganglia - diagnostic imaging Basal Ganglia - metabolism Basal Ganglia - physiopathology Biological and medical sciences Brain Brain Mapping Cerebellum - diagnostic imaging Cerebellum - metabolism Cerebellum - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine Dopamine Plasma Membrane Transport Proteins - metabolism Female Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Medical sciences Middle Aged Neural Pathways - diagnostic imaging Neural Pathways - metabolism Neural Pathways - physiopathology Neurology Parkinson Disease - diagnostic imaging Parkinson Disease - metabolism Parkinson Disease - physiopathology Parkinson's disease Thalamus - diagnostic imaging Thalamus - metabolism Thalamus - physiopathology Tomography, Emission-Computed, Single-Photon Tremor - diagnostic imaging Tremor - metabolism Tremor - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!