Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva)

Significant electrophysiological and biochemical findings suggest that receptor cross-talk occurs between serotonergic 5-HT3- and tachykininergic NK1-receptors in which co-activation of either receptor by ineffective doses of their corresponding agonists (serotonin (5-HT) or substance P (SP), respec...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2011-10, Vol.99 (4), p.573-579
Hauptverfasser:	Darmani, Nissar A., Chebolu, Seetha, Amos, Barry, Alkam, Tursun
Format:	Artikel
Sprache:	eng
Schlagworte:	2-methyl 5-HT 5-HT3 receptor Analysis of Variance Animals Antiemetics - pharmacology Biological and medical sciences Cross-talk Cryptotis parva Dose-Response Relationship, Drug Drug Synergism Emesis Female GR73632 Indoles - pharmacology Interaction Least shrew Male Medical sciences Neurokinin-1 Receptor Antagonists NK1 receptor Peptide Fragments - pharmacology Piperidines - pharmacology Receptors, Neurokinin-1 - agonists Serotonin - analogs & derivatives Serotonin - pharmacology Serotonin 5-HT3 Receptor Antagonists - pharmacology Shrews - physiology Substance P - analogs & derivatives Substance P - pharmacology Synergistic Vomiting - chemically induced Vomiting - prevention & control
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