Synthesis and characterization of recombinant factor VIIa-conjugated magnetic iron oxide nanoparticles for hemophilia treatment

Maghemite (γ‐Fe2O3) nanoparticles of 15.0 ± 2.1 nm in diameter were prepared by nucleation, followed by controlled growth of magnetic iron oxide thin films onto gelatin nuclei. Functionalization of these magnetic nanoparticles with activated double bonds was accomplished by interacting divinyl sulfo...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2009-12, Vol.91A (4), p.1056-1064
Hauptverfasser:	Shafir, Gilead, Galperin, Anna, Margel, Shlomo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biofunctionalization Blood Coagulation - drug effects Enzymes factor VIIa Factor VIIa - chemical synthesis Factor VIIa - pharmacology Factor VIIa - therapeutic use Ferric Compounds - chemical synthesis Ferric Compounds - pharmacology Ferric Compounds - therapeutic use Gelatins hemophilia Hemophilia A - drug therapy Inhibitors iron oxide nanoparticles Magnetics Mathematical models Nanoparticles Nanoparticles - therapeutic use Nanoparticles - ultrastructure Particle Size Recombinant Recombinant Proteins - chemical synthesis Recombinant Proteins - pharmacology Recombinant Proteins - therapeutic use Serum albumin Stabilization surface modification Sus scrofa Temperature Trypsin - pharmacology
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