Genetic modulation of TLR8 response following bacterial phagocytosis

Human Toll-like receptors (TLRs) TLR7, TLR8, and TLR9 are important immune sensors of foreign nucleic acids encountered by phagocytes. Although there is growing evidence implicating TLR7 and TLR9 in the detection of intracellular pathogenic bacteria, characterization of such a role for TLR8 is curre...

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Veröffentlicht in:	Human mutation 2010-09, Vol.31 (9), p.1069-1079
Hauptverfasser:	Gantier, Michael P, Irving, Aaron T, Kaparakis-Liaskos, Maria, Xu, Dakang, Evans, Vanessa A, Cameron, Paul U, Bourne, James A, Ferrero, Richard L, John, Matthias, Behlke, Mark A, Williams, Bryan R.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacteria Base Sequence Cell Line Cell Movement Feedback, Physiological H. pylori Helicobacter pylori - physiology Humans innate immunity Lipopolysaccharide Receptors - metabolism Macrophages Molecular Sequence Data Monocytes - cytology Monocytes - metabolism Monocytes - microbiology Phagocytosis Polymorphism, Single Nucleotide - genetics Protein Biosynthesis Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Transport Receptors, IgG - metabolism splice variants TLR8 Toll-Like Receptor 8 - chemistry Toll-Like Receptor 8 - genetics Toll-Like Receptor 8 - metabolism
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