Effects of imidacloprid exposure on Chironomus riparius Meigen larvae: Linking acetylcholinesterase activity to behaviour
Imidacloprid (IMI) is an insecticide that interferes with the transmission of stimuli in the nervous system of insects. It is neurotoxic by mimicking nicotine through its binding to the nicotinic acetylcholine receptor. In this work, experiments comprising 96 h exposure followed by 48 h in clean med...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 2011-07, Vol.74 (5), p.1210-1215 |
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| creator | Azevedo-Pereira, H.M.V.S. Lemos, M.F.L. Soares, A.M.V.M. |
| description | Imidacloprid (IMI) is an insecticide that interferes with the transmission of stimuli in the nervous system of insects. It is neurotoxic by mimicking nicotine through its binding to the nicotinic acetylcholine receptor. In this work, experiments comprising 96
h exposure followed by 48
h in clean medium were conducted to evaluate the toxicity of IMI to
Chironomus riparius and its potential recovery. Behavioural parameters and AChE activity were assessed. After 96
h exposure to IMI, AChE activity, and the behaviour parameters ventilation and locomotion were reduced. There were no signs of recovery after removal to clean water for 48
h.
Ventilation behaviour was the most sensitive parameter and the one with the highest correlation to AChE activity. Despite the possibility that IMI might be having an indirect effect on AChE activity, the behavioural endpoint showed a higher sensitivity than the biochemical response itself.
This work highlights the importance of linking parameters with ecological relevance at individual level (behavioural parameters) with biochemical responses, to unravel xenobiotics mode of action. |
| doi_str_mv | 10.1016/j.ecoenv.2011.03.018 |
| format | Article |
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h exposure followed by 48
h in clean medium were conducted to evaluate the toxicity of IMI to
Chironomus riparius and its potential recovery. Behavioural parameters and AChE activity were assessed. After 96
h exposure to IMI, AChE activity, and the behaviour parameters ventilation and locomotion were reduced. There were no signs of recovery after removal to clean water for 48
h.
Ventilation behaviour was the most sensitive parameter and the one with the highest correlation to AChE activity. Despite the possibility that IMI might be having an indirect effect on AChE activity, the behavioural endpoint showed a higher sensitivity than the biochemical response itself.
This work highlights the importance of linking parameters with ecological relevance at individual level (behavioural parameters) with biochemical responses, to unravel xenobiotics mode of action.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/j.ecoenv.2011.03.018</identifier><identifier>PMID: 21511337</identifier><identifier>CODEN: EESADV</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>acetylcholinesterase ; Acetylcholinesterase - metabolism ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Behavior, Animal - drug effects ; Behavioural ; Behavioural parameters ; Biochemistry ; Biological and medical sciences ; Chironomidae - drug effects ; Chironomidae - metabolism ; Chironomidae - physiology ; Chironomus riparius ; cholinergic receptors ; Cleaning ; Dose-Response Relationship, Drug ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Fundamental and applied biological sciences. Psychology ; General aspects ; Imidacloprid ; Imidazoles - toxicity ; Insecticides - toxicity ; insects ; Joining ; Larva - drug effects ; Larva - metabolism ; larvae ; Linking ; Linking biomarkers ; locomotion ; mechanism of action ; Motor Activity - drug effects ; Neonicotinoids ; nervous system ; Nervous System - drug effects ; Neurotoxicity ; nicotine ; Nitro Compounds - toxicity ; Recovery ; Techniques ; Ventilation ; xenobiotics</subject><ispartof>Ecotoxicology and environmental safety, 2011-07, Vol.74 (5), p.1210-1215</ispartof><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-951600490b75e603f89436c8e96251ff677392583ec85d878cf9c1bb55dedb723</citedby><cites>FETCH-LOGICAL-c505t-951600490b75e603f89436c8e96251ff677392583ec85d878cf9c1bb55dedb723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0147651311000844$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24293657$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21511337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azevedo-Pereira, H.M.V.S.</creatorcontrib><creatorcontrib>Lemos, M.F.L.</creatorcontrib><creatorcontrib>Soares, A.M.V.M.</creatorcontrib><title>Effects of imidacloprid exposure on Chironomus riparius Meigen larvae: Linking acetylcholinesterase activity to behaviour</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>Imidacloprid (IMI) is an insecticide that interferes with the transmission of stimuli in the nervous system of insects. It is neurotoxic by mimicking nicotine through its binding to the nicotinic acetylcholine receptor. In this work, experiments comprising 96
h exposure followed by 48
h in clean medium were conducted to evaluate the toxicity of IMI to
Chironomus riparius and its potential recovery. Behavioural parameters and AChE activity were assessed. After 96
h exposure to IMI, AChE activity, and the behaviour parameters ventilation and locomotion were reduced. There were no signs of recovery after removal to clean water for 48
h.
Ventilation behaviour was the most sensitive parameter and the one with the highest correlation to AChE activity. Despite the possibility that IMI might be having an indirect effect on AChE activity, the behavioural endpoint showed a higher sensitivity than the biochemical response itself.
This work highlights the importance of linking parameters with ecological relevance at individual level (behavioural parameters) with biochemical responses, to unravel xenobiotics mode of action.</description><subject>acetylcholinesterase</subject><subject>Acetylcholinesterase - metabolism</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioural</subject><subject>Behavioural parameters</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chironomidae - drug effects</subject><subject>Chironomidae - metabolism</subject><subject>Chironomidae - physiology</subject><subject>Chironomus riparius</subject><subject>cholinergic receptors</subject><subject>Cleaning</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Imidacloprid</subject><subject>Imidazoles - toxicity</subject><subject>Insecticides - toxicity</subject><subject>insects</subject><subject>Joining</subject><subject>Larva - drug effects</subject><subject>Larva - metabolism</subject><subject>larvae</subject><subject>Linking</subject><subject>Linking biomarkers</subject><subject>locomotion</subject><subject>mechanism of action</subject><subject>Motor Activity - drug effects</subject><subject>Neonicotinoids</subject><subject>nervous system</subject><subject>Nervous System - drug effects</subject><subject>Neurotoxicity</subject><subject>nicotine</subject><subject>Nitro Compounds - toxicity</subject><subject>Recovery</subject><subject>Techniques</subject><subject>Ventilation</subject><subject>xenobiotics</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2P0zAQhiMEYrsL_wCBL2i5tMzEcexwQELV8iEVcYA9W44zbl3SuNhJRf89rlrgtidb1jOed-YpihcICwSs324XZAMNh0UJiAvgC0D1qJghNDAvK6weFzPASs5rgfyquE5pCwAchHhaXJUoEDmXs-J45xzZMbHgmN_5ztg-7KPvGP3ehzRFYmFgy42PYQi7KbHo9yb6fPlKfk0D6008GHrHVn746Yc1M5bGY283ofcDpZGiSZQfR3_w45GNgbW0MQcfpviseOJMn-j55bwp7j_e_Vh-nq--ffqy_LCaWwFinDcCa4CqgVYKqoE71VS8toqauhToXC0lb0qhOFklOiWVdY3FthWio66VJb8pbs__7mP4NeVMeueTpb43A4UpaaUUgpCKZ_LNgyRKKTEnUU1GqzNqY0gpktN5aTsTjxpBn_TorT7r0Sc9GrjOenLZy0uHqd1R96_or48MvL4AJlnTu2gG69N_riobXosT9-rMORO0WcfM3H_PnSoAlBXH09jvzwTl3R48RZ2sp8FS52MWrrvgH876B6_euhw</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Azevedo-Pereira, H.M.V.S.</creator><creator>Lemos, M.F.L.</creator><creator>Soares, A.M.V.M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SU</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>7QH</scope><scope>7SS</scope><scope>7ST</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope></search><sort><creationdate>20110701</creationdate><title>Effects of imidacloprid exposure on Chironomus riparius Meigen larvae: Linking acetylcholinesterase activity to behaviour</title><author>Azevedo-Pereira, H.M.V.S. ; Lemos, M.F.L. ; Soares, A.M.V.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-951600490b75e603f89436c8e96251ff677392583ec85d878cf9c1bb55dedb723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>acetylcholinesterase</topic><topic>Acetylcholinesterase - metabolism</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioural</topic><topic>Behavioural parameters</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chironomidae - drug effects</topic><topic>Chironomidae - metabolism</topic><topic>Chironomidae - physiology</topic><topic>Chironomus riparius</topic><topic>cholinergic receptors</topic><topic>Cleaning</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Imidacloprid</topic><topic>Imidazoles - toxicity</topic><topic>Insecticides - toxicity</topic><topic>insects</topic><topic>Joining</topic><topic>Larva - drug effects</topic><topic>Larva - metabolism</topic><topic>larvae</topic><topic>Linking</topic><topic>Linking biomarkers</topic><topic>locomotion</topic><topic>mechanism of action</topic><topic>Motor Activity - drug effects</topic><topic>Neonicotinoids</topic><topic>nervous system</topic><topic>Nervous System - drug effects</topic><topic>Neurotoxicity</topic><topic>nicotine</topic><topic>Nitro Compounds - toxicity</topic><topic>Recovery</topic><topic>Techniques</topic><topic>Ventilation</topic><topic>xenobiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azevedo-Pereira, H.M.V.S.</creatorcontrib><creatorcontrib>Lemos, M.F.L.</creatorcontrib><creatorcontrib>Soares, A.M.V.M.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Aqualine</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environment Abstracts</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azevedo-Pereira, H.M.V.S.</au><au>Lemos, M.F.L.</au><au>Soares, A.M.V.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of imidacloprid exposure on Chironomus riparius Meigen larvae: Linking acetylcholinesterase activity to behaviour</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>74</volume><issue>5</issue><spage>1210</spage><epage>1215</epage><pages>1210-1215</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>Imidacloprid (IMI) is an insecticide that interferes with the transmission of stimuli in the nervous system of insects. It is neurotoxic by mimicking nicotine through its binding to the nicotinic acetylcholine receptor. In this work, experiments comprising 96
h exposure followed by 48
h in clean medium were conducted to evaluate the toxicity of IMI to
Chironomus riparius and its potential recovery. Behavioural parameters and AChE activity were assessed. After 96
h exposure to IMI, AChE activity, and the behaviour parameters ventilation and locomotion were reduced. There were no signs of recovery after removal to clean water for 48
h.
Ventilation behaviour was the most sensitive parameter and the one with the highest correlation to AChE activity. Despite the possibility that IMI might be having an indirect effect on AChE activity, the behavioural endpoint showed a higher sensitivity than the biochemical response itself.
This work highlights the importance of linking parameters with ecological relevance at individual level (behavioural parameters) with biochemical responses, to unravel xenobiotics mode of action.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>21511337</pmid><doi>10.1016/j.ecoenv.2011.03.018</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acetylcholinesterase Acetylcholinesterase - metabolism Animal, plant and microbial ecology Animals Applied ecology Behavior, Animal - drug effects Behavioural Behavioural parameters Biochemistry Biological and medical sciences Chironomidae - drug effects Chironomidae - metabolism Chironomidae - physiology Chironomus riparius cholinergic receptors Cleaning Dose-Response Relationship, Drug Ecotoxicology Ecotoxicology, biological effects of pollution Fundamental and applied biological sciences. Psychology General aspects Imidacloprid Imidazoles - toxicity Insecticides - toxicity insects Joining Larva - drug effects Larva - metabolism larvae Linking Linking biomarkers locomotion mechanism of action Motor Activity - drug effects Neonicotinoids nervous system Nervous System - drug effects Neurotoxicity nicotine Nitro Compounds - toxicity Recovery Techniques Ventilation xenobiotics |
| title | Effects of imidacloprid exposure on Chironomus riparius Meigen larvae: Linking acetylcholinesterase activity to behaviour |
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