The Influence of Low Oxygen on Macrophage Response to Leishmania Infection

Hypoxia (low oxygen tension) is a common feature of inflamed and infected tissues. The influence of hypoxia on macrophage responses to micro‐organisms has only recently been studied. This study demonstrates that hypoxia induced macrophages to control Leishmania amazonensis, an intracellular parasite...

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Veröffentlicht in:	Scandinavian journal of immunology 2011-08, Vol.74 (2), p.165-175
Hauptverfasser:	Degrossoli, A., Arrais‐Silva, W. W., Colhone, M. C., Gadelha, F. R., Joazeiro, P. P., Giorgio, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacology Animals Antioxidants Azoles - pharmacology Basic Helix-Loop-Helix Transcription Factors - biosynthesis Basic Helix-Loop-Helix Transcription Factors - immunology Data processing Exocytosis Female Free Radical Scavengers - pharmacology Hypoxia Hypoxia - immunology Hypoxia - metabolism Hypoxia-inducible factor 1 Hypoxia-inducible factor 1 alpha Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis Hypoxia-Inducible Factor 1, alpha Subunit - immunology Infection Inflammation Interleukin 10 Interleukin 12 Interleukin-10 - immunology Interleukin-12 - immunology Leishmania amazonensis Leishmaniasis, Cutaneous - immunology Leishmaniasis, Cutaneous - metabolism Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages - ultrastructure Metabolism Metastases Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microenvironments Nitric oxide Nitric Oxide - immunology Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - immunology Organoselenium Compounds - pharmacology Oxygen tension Parasitism Reactive oxygen species Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism Tumor necrosis factor- alpha Tumor Necrosis Factor-alpha - immunology
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