investigation of intracellular glycosylation activities in CHO cells: Effects of nucleotide sugar precursor feeding

Controlling glycosylation of recombinant proteins produced by CHO cells is highly desired as it can be directed towards maintaining or increasing product quality. To further our understanding of the different factors influencing glycosylation, a glycosylation sub-array of 79 genes and a capillary el...

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Veröffentlicht in:	Biotechnology and bioengineering 2010-10, Vol.107 (2), p.321-336
Hauptverfasser:	Wong, Niki S.C, Wati, Lydia, Nissom, Peter M, Feng, H.T, Lee, M.M, Yap, Miranda G.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Carbohydrate Metabolism Cell culture Cells CHO Cells Cricetinae Cricetulus Culture Media - chemistry Cytidine - metabolism Fundamental and applied biological sciences. Psychology Galactose - metabolism Gene expression Glucosamine - metabolism Glycoproteins - metabolism Glycosylation Hexosamines - metabolism Interferon Interferon-gamma - metabolism nucleotide sugars Nucleotides - metabolism precursor feeding Protein folding protein quality Recombinant Proteins - metabolism Uridine - metabolism
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