MicroRNA-193a represses c-kit expression and functions as a methylation-silenced tumor suppressor in acute myeloid leukemia

Aberrant activation of c-kit proto-oncogene contributes to abnormal cell proliferation by altering the tyrosine kinase signaling and constitutes a crucial impetus for leukemogenesis. Epigenetic silencing of tumor-suppressive microRNAs (miRNAs) is a key oncogenic mechanism for the activation of oncog...

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Veröffentlicht in:	Oncogene 2011-08, Vol.30 (31), p.3416-3428
Hauptverfasser:	Gao, X-N, Lin, J, Li, Y-H, Gao, L, Wang, X-R, Wang, W, Kang, H-Y, Yan, G-T, Wang, L-L, Yu, L
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 631/208/2489/2487/2486 631/337/384/331 631/67/581 692/699/67/1990/283/1897 Acute myeloid leukemia Adolescent Adult Aged Antineoplastic Agents - pharmacology Apoptosis Azacitidine - pharmacology Azacytidine Biological and medical sciences Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism c-Kit protein Cell Biology Cell growth Cell Line, Tumor Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured CpG Islands DNA Methylation Epigenetics Female Fundamental and applied biological sciences. Psychology Gene expression Gene Silencing - drug effects Genes, Tumor Suppressor - drug effects Health aspects Hematologic and hematopoietic diseases Human Genetics Humans Internal Medicine Kinases Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukemogenesis Luciferase Male Medical sciences Medicine Medicine & Public Health Methylation MicroRNAs MicroRNAs - metabolism Middle Aged miRNA Molecular and cellular biology Monocytes - drug effects Monocytes - metabolism mRNA Oncology original-article Promoter Regions, Genetic Protein-tyrosine kinase Proto-Oncogene Proteins c-kit - biosynthesis Ribonucleic acid RNA Transfection Tumor cell lines Tumor suppressor genes Tumors Young Adult
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