In vitro genotoxicity of danthron and its potential mechanism

To ascertain the in vitro genotoxicity of danthron and its potential mechanism of action, we performed an Ames test, a cytokinesis-block micronucleus assay and a comet assay in Balb/c 3T3 cells. The Ames test revealed that danthron was mutagenic only toward Salmonella typhimurium strain TA102 in the...

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Veröffentlicht in:	Mutation research 2011-05, Vol.722 (1), p.39-43
Hauptverfasser:	Zhang, Zhaohui, Fu, Juanling, Yao, Biyun, Zhang, Xiaolin, Zhao, Peng, Zhou, Zongcan
Format:	Artikel
Sprache:	eng
Schlagworte:	1,8-Dihydroxyanthraquinone Animals Anthraquinones - metabolism Anthraquinones - toxicity BALB 3T3 Cells Bioassays Biological and medical sciences Biotransformation Comet Assay Cytokines Danthron Dicumarol - pharmacology Dose-Response Relationship, Drug DT-diaphorase Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Medical sciences Metabolism Mice Micronucleus Tests Mutagenesis Mutagenicity Mutagenicity Tests Mutagens - toxicity NAD(P)H Dehydrogenase (Quinone) - metabolism NADP - chemistry Olea Oxidative Stress Salmonella Salmonella typhimurium Salmonella typhimurium - genetics Toxicity Toxicology
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