Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury

Abstract Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a hypoxia-inducible neuroprotective protein that also stimulates proliferation of neuronal precursor cells. In this study, we investigated the possible role of HB-EGF in ischemia and reperfusion injury by measuring the c...

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Veröffentlicht in:	Neuroscience 2011-06, Vol.185, p.116-124
Hauptverfasser:	Oyagi, A, Morimoto, N, Hamanaka, J, Ishiguro, M, Tsuruma, K, Shimazawa, M, Hara, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Stem Cells - physiology Analysis of Variance Animals Biological and medical sciences Brain Infarction - etiology Brain Infarction - pathology Bromodeoxyuridine - metabolism Cerebral Ventricles - physiology Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Disease Models, Animal Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation - genetics HB-EGF Heparin-binding EGF-like Growth Factor In Situ Nick-End Labeling - methods Infarction, Middle Cerebral Artery - pathology Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism MCAO Mice Mice, Knockout Neurology oxidative stress proliferation Prosencephalon - metabolism Reperfusion Injury - complications Reperfusion Injury - pathology RNA, Messenger - metabolism subventricular zone Transforming Growth Factor alpha - genetics Transforming Growth Factor alpha - metabolism Vertebrates: nervous system and sense organs
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