Effects of exogenous GSH and methionine on methylation of inorganic arsenic in mice exposed to arsenite through drinking water

We hypothesized that chronic exposure to arsenic would deplete the reduced glutathione (GSH) and methionine in vivo, thereby impair the methylation capacity of inorganic arsenic (iAs) ingested. Our experiment was designed to explore the effects of exogenous GSH and methionine on arsenic methylation...

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Veröffentlicht in:	Environmental toxicology 2010-08, Vol.25 (4), p.361-366
Hauptverfasser:	Jin, Yaping, Zhao, Fenghong, Zhong, Yuan, Yu, Xiaoyun, Sun, Di, Liao, Yingjun, Lv, Xiuqiang, Li, Gexin, Sun, Guifan
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animal, plant and microbial ecology Animals Applied ecology Arsenic - blood Arsenic - toxicity arsenic methylation Arsenic Poisoning - metabolism arsenite Arsenites - toxicity Biological and medical sciences Cacodylic Acid - metabolism Drinking Ecotoxicology, biological effects of pollution Environmental Exposure Female Fundamental and applied biological sciences. Psychology General aspects glutathione Glutathione - metabolism Glutathione - pharmacology Liver - metabolism methionine Methionine - metabolism Methionine - pharmacology Methylation Mice Mice, Inbred Strains Techniques
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