Modeling kinetics of a large-scale fed-batch CHO cell culture by Markov chain Monte Carlo method

Markov chain Monte Carlo (MCMC) method was applied to model kinetics of a fed‐batch Chinese hamster ovary cell culture process in 5,000‐L bioreactors. The kinetic model consists of six differential equations, which describe dynamics of viable cell density and concentrations of glucose, glutamine, am...

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Veröffentlicht in:	Biotechnology progress 2010-01, Vol.26 (1), p.208-219
Hauptverfasser:	Xing, Zizhuo, Bishop, Nikki, Leister, Kirk, Li, Zheng Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Ammonia - chemistry Animals Antibodies - chemistry bayesian parameter estimation Biological and medical sciences Biotechnology Cell Culture Techniques Cells, Cultured Chinese hamster ovary cell culture CHO Cells Cricetinae Cricetulus Fundamental and applied biological sciences. Psychology Glucose - chemistry Glutamine - chemistry kinetic model Kinetics Lactic Acid - chemistry MCMC sampling Models, Chemical monod equation Monte Carlo Method Recombinant Fusion Proteins - chemistry
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