Specific targeting of the GABA-A receptor alpha 5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome (DS). Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system and accordingly treatment with GABA...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2011-08, Vol.25 (8), p.1030-1042
Hauptverfasser:	Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, R H, Herault, Y, Potier, M-C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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