Oral Administration of Clostridium butyricum for Modulating Gastrointestinal Microflora in Mice
This study aimed to evaluate the safety of Clostridium butyricum and to investigate the effect of C. butyricum on mice ecosystem in the intestinal tract by way of examining the population of different microorganisms isolated from caecal contents. We firstly evaluated the safety of C. butyricum using...
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| Veröffentlicht in: | Current microbiology 2011-02, Vol.62 (2), p.512-517 |
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| creator | Kong, Qing He, Guo-Qing Jia, Ji-Lei Zhu, Qi-Long Ruan, Hui |
| description | This study aimed to evaluate the safety of Clostridium butyricum and to investigate the effect of C. butyricum on mice ecosystem in the intestinal tract by way of examining the population of different microorganisms isolated from caecal contents. We firstly evaluated the safety of C. butyricum using acute toxicity test and Ames test. Then forty male BALB/c mice were divided into the following four treatment groups, each consisting of ten mice: normal group, low-dose group, medium-dose group and high-dose group. Caecal contents were removed aseptically, immediately placed into an anaerobic chamber, and dissolved in sterile pre-reduced PBS. The determination of Enterococcus spp., Enterobacter spp., Lactobacillus spp., Bifidobacterium spp. and Clostridium perfringens was analyzed by the spread plate method, cell morphologies and biochemical profiles. The results showed the oral maximum tolerated dose of C. butyricum was more than 10 g/kg body weight in mice and no mutagenicity judged by negative experimental results of Ames test. And in medium- and high-dose groups, the populations of Bifidobacterium spp. and Lactobacillus spp. increased in caecum, as well as the ratios of Bifidobacterium spp. and Lactobacillus spp. to Clostridium perfringens (P < 0.01) as compared with the normal group. This research showed the intake of C. butyricum significantly improved the ecosystem of the intestinal tract in BALB/c mice by increasing the amount of probiotics and reducing the populations of unwanted bacteria. |
| doi_str_mv | 10.1007/s00284-010-9737-8 |
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We firstly evaluated the safety of C. butyricum using acute toxicity test and Ames test. Then forty male BALB/c mice were divided into the following four treatment groups, each consisting of ten mice: normal group, low-dose group, medium-dose group and high-dose group. Caecal contents were removed aseptically, immediately placed into an anaerobic chamber, and dissolved in sterile pre-reduced PBS. The determination of Enterococcus spp., Enterobacter spp., Lactobacillus spp., Bifidobacterium spp. and Clostridium perfringens was analyzed by the spread plate method, cell morphologies and biochemical profiles. The results showed the oral maximum tolerated dose of C. butyricum was more than 10 g/kg body weight in mice and no mutagenicity judged by negative experimental results of Ames test. And in medium- and high-dose groups, the populations of Bifidobacterium spp. and Lactobacillus spp. increased in caecum, as well as the ratios of Bifidobacterium spp. and Lactobacillus spp. to Clostridium perfringens (P < 0.01) as compared with the normal group. This research showed the intake of C. butyricum significantly improved the ecosystem of the intestinal tract in BALB/c mice by increasing the amount of probiotics and reducing the populations of unwanted bacteria.</description><identifier>ISSN: 0343-8651</identifier><identifier>EISSN: 1432-0991</identifier><identifier>DOI: 10.1007/s00284-010-9737-8</identifier><identifier>PMID: 20711781</identifier><language>eng</language><publisher>New York: New York : Springer-Verlag</publisher><subject>Acute toxicity ; Administration, Oral ; Ames test ; Animals ; Bacteria ; Bacterial Load ; Bifidobacterium ; Biomedical and Life Sciences ; Biotechnology ; Body weight ; Cecum - microbiology ; Clostridium butyricum ; Clostridium butyricum - growth & development ; Clostridium perfringens ; Diet Therapy - adverse effects ; Diet Therapy - methods ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; DNA, Ribosomal - chemistry ; DNA, Ribosomal - genetics ; Enterobacter ; Enterococcus ; Female ; Gastroenterology ; Gastrointestinal Tract - microbiology ; Lactobacillus ; Life Sciences ; Male ; Mice ; Mice, Inbred BALB C ; Microbiology ; Microorganisms ; Molecular Sequence Data ; Mutagenicity ; Probiotics ; RNA, Ribosomal, 16S - genetics ; Rodents ; Sequence Analysis, DNA ; Toxicity</subject><ispartof>Current microbiology, 2011-02, Vol.62 (2), p.512-517</ispartof><rights>Springer Science+Business Media, LLC 2010</rights><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-65969efd6a3eafa8ea1acbae4560b44f3ca2e3dab79a5b25ea303a64182ccc5f3</citedby><cites>FETCH-LOGICAL-c492t-65969efd6a3eafa8ea1acbae4560b44f3ca2e3dab79a5b25ea303a64182ccc5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00284-010-9737-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00284-010-9737-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20711781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kong, Qing</creatorcontrib><creatorcontrib>He, Guo-Qing</creatorcontrib><creatorcontrib>Jia, Ji-Lei</creatorcontrib><creatorcontrib>Zhu, Qi-Long</creatorcontrib><creatorcontrib>Ruan, Hui</creatorcontrib><title>Oral Administration of Clostridium butyricum for Modulating Gastrointestinal Microflora in Mice</title><title>Current microbiology</title><addtitle>Curr Microbiol</addtitle><addtitle>Curr Microbiol</addtitle><description>This study aimed to evaluate the safety of Clostridium butyricum and to investigate the effect of C. butyricum on mice ecosystem in the intestinal tract by way of examining the population of different microorganisms isolated from caecal contents. We firstly evaluated the safety of C. butyricum using acute toxicity test and Ames test. Then forty male BALB/c mice were divided into the following four treatment groups, each consisting of ten mice: normal group, low-dose group, medium-dose group and high-dose group. Caecal contents were removed aseptically, immediately placed into an anaerobic chamber, and dissolved in sterile pre-reduced PBS. The determination of Enterococcus spp., Enterobacter spp., Lactobacillus spp., Bifidobacterium spp. and Clostridium perfringens was analyzed by the spread plate method, cell morphologies and biochemical profiles. The results showed the oral maximum tolerated dose of C. butyricum was more than 10 g/kg body weight in mice and no mutagenicity judged by negative experimental results of Ames test. And in medium- and high-dose groups, the populations of Bifidobacterium spp. and Lactobacillus spp. increased in caecum, as well as the ratios of Bifidobacterium spp. and Lactobacillus spp. to Clostridium perfringens (P < 0.01) as compared with the normal group. This research showed the intake of C. butyricum significantly improved the ecosystem of the intestinal tract in BALB/c mice by increasing the amount of probiotics and reducing the populations of unwanted bacteria.</description><subject>Acute toxicity</subject><subject>Administration, Oral</subject><subject>Ames test</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Bacterial Load</subject><subject>Bifidobacterium</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Body weight</subject><subject>Cecum - microbiology</subject><subject>Clostridium butyricum</subject><subject>Clostridium butyricum - growth & development</subject><subject>Clostridium perfringens</subject><subject>Diet Therapy - adverse effects</subject><subject>Diet Therapy - methods</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>DNA, Ribosomal - chemistry</subject><subject>DNA, Ribosomal - genetics</subject><subject>Enterobacter</subject><subject>Enterococcus</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Tract - microbiology</subject><subject>Lactobacillus</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Molecular Sequence Data</subject><subject>Mutagenicity</subject><subject>Probiotics</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>Rodents</subject><subject>Sequence Analysis, 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Administration of Clostridium butyricum for Modulating Gastrointestinal Microflora in Mice</title><author>Kong, Qing ; He, Guo-Qing ; Jia, Ji-Lei ; Zhu, Qi-Long ; Ruan, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-65969efd6a3eafa8ea1acbae4560b44f3ca2e3dab79a5b25ea303a64182ccc5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acute toxicity</topic><topic>Administration, Oral</topic><topic>Ames test</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Bacterial Load</topic><topic>Bifidobacterium</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Body weight</topic><topic>Cecum - microbiology</topic><topic>Clostridium butyricum</topic><topic>Clostridium butyricum - growth & development</topic><topic>Clostridium perfringens</topic><topic>Diet Therapy - adverse effects</topic><topic>Diet Therapy - methods</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>DNA, Ribosomal - chemistry</topic><topic>DNA, Ribosomal - genetics</topic><topic>Enterobacter</topic><topic>Enterococcus</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Gastrointestinal Tract - microbiology</topic><topic>Lactobacillus</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Molecular Sequence Data</topic><topic>Mutagenicity</topic><topic>Probiotics</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>Rodents</topic><topic>Sequence Analysis, DNA</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kong, Qing</creatorcontrib><creatorcontrib>He, Guo-Qing</creatorcontrib><creatorcontrib>Jia, Ji-Lei</creatorcontrib><creatorcontrib>Zhu, 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Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><jtitle>Current microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kong, Qing</au><au>He, Guo-Qing</au><au>Jia, Ji-Lei</au><au>Zhu, Qi-Long</au><au>Ruan, Hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Administration of Clostridium butyricum for Modulating Gastrointestinal Microflora in Mice</atitle><jtitle>Current microbiology</jtitle><stitle>Curr Microbiol</stitle><addtitle>Curr Microbiol</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>62</volume><issue>2</issue><spage>512</spage><epage>517</epage><pages>512-517</pages><issn>0343-8651</issn><eissn>1432-0991</eissn><abstract>This study aimed to evaluate the safety of Clostridium butyricum and to investigate the effect of C. butyricum on mice ecosystem in the intestinal tract by way of examining the population of different microorganisms isolated from caecal contents. We firstly evaluated the safety of C. butyricum using acute toxicity test and Ames test. Then forty male BALB/c mice were divided into the following four treatment groups, each consisting of ten mice: normal group, low-dose group, medium-dose group and high-dose group. Caecal contents were removed aseptically, immediately placed into an anaerobic chamber, and dissolved in sterile pre-reduced PBS. The determination of Enterococcus spp., Enterobacter spp., Lactobacillus spp., Bifidobacterium spp. and Clostridium perfringens was analyzed by the spread plate method, cell morphologies and biochemical profiles. The results showed the oral maximum tolerated dose of C. butyricum was more than 10 g/kg body weight in mice and no mutagenicity judged by negative experimental results of Ames test. And in medium- and high-dose groups, the populations of Bifidobacterium spp. and Lactobacillus spp. increased in caecum, as well as the ratios of Bifidobacterium spp. and Lactobacillus spp. to Clostridium perfringens (P < 0.01) as compared with the normal group. This research showed the intake of C. butyricum significantly improved the ecosystem of the intestinal tract in BALB/c mice by increasing the amount of probiotics and reducing the populations of unwanted bacteria.</abstract><cop>New York</cop><pub>New York : Springer-Verlag</pub><pmid>20711781</pmid><doi>10.1007/s00284-010-9737-8</doi><tpages>6</tpages></addata></record> |
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| subjects | Acute toxicity Administration, Oral Ames test Animals Bacteria Bacterial Load Bifidobacterium Biomedical and Life Sciences Biotechnology Body weight Cecum - microbiology Clostridium butyricum Clostridium butyricum - growth & development Clostridium perfringens Diet Therapy - adverse effects Diet Therapy - methods DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Ribosomal - chemistry DNA, Ribosomal - genetics Enterobacter Enterococcus Female Gastroenterology Gastrointestinal Tract - microbiology Lactobacillus Life Sciences Male Mice Mice, Inbred BALB C Microbiology Microorganisms Molecular Sequence Data Mutagenicity Probiotics RNA, Ribosomal, 16S - genetics Rodents Sequence Analysis, DNA Toxicity |
| title | Oral Administration of Clostridium butyricum for Modulating Gastrointestinal Microflora in Mice |
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