A mild acute hemolytic transfusion reaction in a patient with alloanti‐Ge3: a case report and review of the literature
BACKGROUND: The clinical significance of the Gerbich antibodies has been described as variable and there are no well‐documented reports of hemolytic transfusion reactions (HTRs). CASE REPORT: We present the case of a woman with a long history of documented anti‐Ge3 alloantibody who received multiple...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2011-09, Vol.51 (9), p.1966-1971 |
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| container_end_page | 1971 |
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| container_issue | 9 |
| container_start_page | 1966 |
| container_title | Transfusion (Philadelphia, Pa.) |
| container_volume | 51 |
| creator | Baughn, Mariah R. Whitacre, Patricia Lo, Grace S. Pandey, Suchitra Lane, Thomas A. |
| description | BACKGROUND: The clinical significance of the Gerbich antibodies has been described as variable and there are no well‐documented reports of hemolytic transfusion reactions (HTRs).
CASE REPORT: We present the case of a woman with a long history of documented anti‐Ge3 alloantibody who received multiple units of Ge+ red blood cells (RBCs) uneventfully. During the first admission to our hospital she was transfused 8 units of Ge+ RBCs and had a negative monocyte monolayer assay (MMA) before receiving the units. Within 2 weeks of the transfusions, the anti‐Ge3 became significantly stronger by indirect antiglobulin test, and the MMA increased from 2.2 to 79.5% reactivity. She returned 4.5 years later with an emergent need for blood and was transfused with 2 units of Ge+ RBCs after premedication with steroids and intravenous immunoglobulin.
RESULTS: The first unit was transfused without incident; however, she developed clinical and laboratory signs consistent with an acute HTR with the second unit.
CONCLUSION: After a comprehensive review of the literature, we believe this to be the first well‐documented case of acute HTR due to anti‐Gerbich alloantibodies. |
| doi_str_mv | 10.1111/j.1537-2995.2011.03093.x |
| format | Article |
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CASE REPORT: We present the case of a woman with a long history of documented anti‐Ge3 alloantibody who received multiple units of Ge+ red blood cells (RBCs) uneventfully. During the first admission to our hospital she was transfused 8 units of Ge+ RBCs and had a negative monocyte monolayer assay (MMA) before receiving the units. Within 2 weeks of the transfusions, the anti‐Ge3 became significantly stronger by indirect antiglobulin test, and the MMA increased from 2.2 to 79.5% reactivity. She returned 4.5 years later with an emergent need for blood and was transfused with 2 units of Ge+ RBCs after premedication with steroids and intravenous immunoglobulin.
RESULTS: The first unit was transfused without incident; however, she developed clinical and laboratory signs consistent with an acute HTR with the second unit.
CONCLUSION: After a comprehensive review of the literature, we believe this to be the first well‐documented case of acute HTR due to anti‐Gerbich alloantibodies.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2011.03093.x</identifier><identifier>PMID: 21392022</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Drug toxicity and drugs side effects treatment ; Erythrocyte Transfusion - adverse effects ; Female ; Glycophorin - immunology ; Hemolysis - immunology ; Humans ; Isoantibodies - immunology ; Medical sciences ; Pharmacology. Drug treatments ; Toxicity: blood ; Transfusion Reaction ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2011-09, Vol.51 (9), p.1966-1971</ispartof><rights>2011 American Association of Blood Banks</rights><rights>2015 INIST-CNRS</rights><rights>2011 American Association of Blood Banks.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3983-38421fbae13fec3c9213c95d7eccc101cdc58e6b6c3766a93660c3a43cf8cfb83</citedby><cites>FETCH-LOGICAL-c3983-38421fbae13fec3c9213c95d7eccc101cdc58e6b6c3766a93660c3a43cf8cfb83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2011.03093.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2011.03093.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24563396$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21392022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baughn, Mariah R.</creatorcontrib><creatorcontrib>Whitacre, Patricia</creatorcontrib><creatorcontrib>Lo, Grace S.</creatorcontrib><creatorcontrib>Pandey, Suchitra</creatorcontrib><creatorcontrib>Lane, Thomas A.</creatorcontrib><title>A mild acute hemolytic transfusion reaction in a patient with alloanti‐Ge3: a case report and review of the literature</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: The clinical significance of the Gerbich antibodies has been described as variable and there are no well‐documented reports of hemolytic transfusion reactions (HTRs).
CASE REPORT: We present the case of a woman with a long history of documented anti‐Ge3 alloantibody who received multiple units of Ge+ red blood cells (RBCs) uneventfully. During the first admission to our hospital she was transfused 8 units of Ge+ RBCs and had a negative monocyte monolayer assay (MMA) before receiving the units. Within 2 weeks of the transfusions, the anti‐Ge3 became significantly stronger by indirect antiglobulin test, and the MMA increased from 2.2 to 79.5% reactivity. She returned 4.5 years later with an emergent need for blood and was transfused with 2 units of Ge+ RBCs after premedication with steroids and intravenous immunoglobulin.
RESULTS: The first unit was transfused without incident; however, she developed clinical and laboratory signs consistent with an acute HTR with the second unit.
CONCLUSION: After a comprehensive review of the literature, we believe this to be the first well‐documented case of acute HTR due to anti‐Gerbich alloantibodies.</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Erythrocyte Transfusion - adverse effects</subject><subject>Female</subject><subject>Glycophorin - immunology</subject><subject>Hemolysis - immunology</subject><subject>Humans</subject><subject>Isoantibodies - immunology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Toxicity: blood</subject><subject>Transfusion Reaction</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMGO0zAQhi0EYsvCKyBfEKcEO9OkNhKH1YpdkFZCQsvZcicT1ZWTFNuh7W0fgWfkSXBoWa744l-a77dHH2NcilLm825byhpWRaV1XVZCylKA0FAenrDF4-ApWwixlIWUUF2wFzFuhRCVFvI5u6gk6EpU1YIdrnjvfMstTon4hvrRH5NDnoIdYjdFNw48kMU0Bzdwy3c2ORoS37u04db70Q7J_Xr4eUvwPo_RRsqN3RgSt0Ob4w9Hez52PG2Ie5co2DQFesmeddZHenW-L9m3m4_315-Kuy-3n6-v7goEraAAtaxkt7YkoSME1Hl11HW7IkSUQmKLtaJm3SCsmsZqaBqBYJeAncJureCSvT29uwvj94liMr2LSN7bgcYpGqWU0GKlIJPqRGIYYwzUmV1wvQ1HI4WZtZutme2a2a6ZtZs_2s0hV1-fP5nWPbWPxb-eM_DmDNiI1nfZLrr4j1vWDYBuMvfhxO2dp-N_L2Duv97MCX4DJDmgJQ</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Baughn, Mariah R.</creator><creator>Whitacre, Patricia</creator><creator>Lo, Grace S.</creator><creator>Pandey, Suchitra</creator><creator>Lane, Thomas A.</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>A mild acute hemolytic transfusion reaction in a patient with alloanti‐Ge3: a case report and review of the literature</title><author>Baughn, Mariah R. ; Whitacre, Patricia ; Lo, Grace S. ; Pandey, Suchitra ; Lane, Thomas A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3983-38421fbae13fec3c9213c95d7eccc101cdc58e6b6c3766a93660c3a43cf8cfb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Erythrocyte Transfusion - adverse effects</topic><topic>Female</topic><topic>Glycophorin - immunology</topic><topic>Hemolysis - immunology</topic><topic>Humans</topic><topic>Isoantibodies - immunology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Toxicity: blood</topic><topic>Transfusion Reaction</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baughn, Mariah R.</creatorcontrib><creatorcontrib>Whitacre, Patricia</creatorcontrib><creatorcontrib>Lo, Grace S.</creatorcontrib><creatorcontrib>Pandey, Suchitra</creatorcontrib><creatorcontrib>Lane, Thomas A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baughn, Mariah R.</au><au>Whitacre, Patricia</au><au>Lo, Grace S.</au><au>Pandey, Suchitra</au><au>Lane, Thomas A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mild acute hemolytic transfusion reaction in a patient with alloanti‐Ge3: a case report and review of the literature</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2011-09</date><risdate>2011</risdate><volume>51</volume><issue>9</issue><spage>1966</spage><epage>1971</epage><pages>1966-1971</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: The clinical significance of the Gerbich antibodies has been described as variable and there are no well‐documented reports of hemolytic transfusion reactions (HTRs).
CASE REPORT: We present the case of a woman with a long history of documented anti‐Ge3 alloantibody who received multiple units of Ge+ red blood cells (RBCs) uneventfully. During the first admission to our hospital she was transfused 8 units of Ge+ RBCs and had a negative monocyte monolayer assay (MMA) before receiving the units. Within 2 weeks of the transfusions, the anti‐Ge3 became significantly stronger by indirect antiglobulin test, and the MMA increased from 2.2 to 79.5% reactivity. She returned 4.5 years later with an emergent need for blood and was transfused with 2 units of Ge+ RBCs after premedication with steroids and intravenous immunoglobulin.
RESULTS: The first unit was transfused without incident; however, she developed clinical and laboratory signs consistent with an acute HTR with the second unit.
CONCLUSION: After a comprehensive review of the literature, we believe this to be the first well‐documented case of acute HTR due to anti‐Gerbich alloantibodies.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21392022</pmid><doi>10.1111/j.1537-2995.2011.03093.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Drug toxicity and drugs side effects treatment Erythrocyte Transfusion - adverse effects Female Glycophorin - immunology Hemolysis - immunology Humans Isoantibodies - immunology Medical sciences Pharmacology. Drug treatments Toxicity: blood Transfusion Reaction Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | A mild acute hemolytic transfusion reaction in a patient with alloanti‐Ge3: a case report and review of the literature |
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