Cord blood stem cell banking: a snapshot of the Italian situation
BACKGROUND: In Italy, the law does not permit the setting up of private banks to preserve cord blood (CB) stem cells for personal use. However, since 2007 the right to export and preserve them in private laboratories located outside Italy has existed, and an increasing number of women are requesting...
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Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2011-09, Vol.51 (9), p.1985-1994 |
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container_end_page | 1994 |
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container_issue | 9 |
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container_title | Transfusion (Philadelphia, Pa.) |
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creator | Capone, Francesca Lombardini, Letizia Pupella, Simonetta Grazzini, Giuliano Costa, Alessandro Nanni Migliaccio, Giovanni |
description | BACKGROUND: In Italy, the law does not permit the setting up of private banks to preserve cord blood (CB) stem cells for personal use. However, since 2007 the right to export and preserve them in private laboratories located outside Italy has existed, and an increasing number of women are requesting this collection of umbilical CB at delivery to enable storage of stem cells for autologous use.
STUDY DESIGN AND METHODS: Since private banks recruit clients mainly via the Internet, we examined the content of 24 Italian‐language websites that offer stem cells storage (from CB or amniotic fluid), to assess what information is available.
RESULTS: We found that the majority of private banks give no clear information about the procedures of collection, processing, and banking of CB units and that the standards offered by private CB banks strongly differ in terms of exclusion or acceptance criteria from the public banks. These factors may well influence the overall quality of the CB units stored in private CB banks. Of note, during the period 2007 to 2009, the number collected for autologous use did not create a downward trend on the number of units stored in public CB banks for allogeneic use.
CONCLUSION: CB is a valuable community resource but expectant parents should be better informed as to the quality variables necessary for its storage, both by institutions and by professionals. Currently, most of the advertising is insufficient to justify the expense and the hopes pinned on autologous use of CB stem cells. |
doi_str_mv | 10.1111/j.1537-2995.2011.03089.x |
format | Article |
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STUDY DESIGN AND METHODS: Since private banks recruit clients mainly via the Internet, we examined the content of 24 Italian‐language websites that offer stem cells storage (from CB or amniotic fluid), to assess what information is available.
RESULTS: We found that the majority of private banks give no clear information about the procedures of collection, processing, and banking of CB units and that the standards offered by private CB banks strongly differ in terms of exclusion or acceptance criteria from the public banks. These factors may well influence the overall quality of the CB units stored in private CB banks. Of note, during the period 2007 to 2009, the number collected for autologous use did not create a downward trend on the number of units stored in public CB banks for allogeneic use.
CONCLUSION: CB is a valuable community resource but expectant parents should be better informed as to the quality variables necessary for its storage, both by institutions and by professionals. Currently, most of the advertising is insufficient to justify the expense and the hopes pinned on autologous use of CB stem cells.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2011.03089.x</identifier><identifier>PMID: 21418078</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Banks - statistics & numerical data ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cryopreservation ; Fetal Blood ; Humans ; Italy ; Medical sciences ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2011-09, Vol.51 (9), p.1985-1994</ispartof><rights>2011 American Association of Blood Banks</rights><rights>2015 INIST-CNRS</rights><rights>2011 American Association of Blood Banks.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4369-d84d66843ef96e33c554a844f5dbb3d3b6433333c011bd20b5881044275bdbf13</citedby><cites>FETCH-LOGICAL-c4369-d84d66843ef96e33c554a844f5dbb3d3b6433333c011bd20b5881044275bdbf13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2011.03089.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2011.03089.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24563400$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21418078$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Capone, Francesca</creatorcontrib><creatorcontrib>Lombardini, Letizia</creatorcontrib><creatorcontrib>Pupella, Simonetta</creatorcontrib><creatorcontrib>Grazzini, Giuliano</creatorcontrib><creatorcontrib>Costa, Alessandro Nanni</creatorcontrib><creatorcontrib>Migliaccio, Giovanni</creatorcontrib><title>Cord blood stem cell banking: a snapshot of the Italian situation</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: In Italy, the law does not permit the setting up of private banks to preserve cord blood (CB) stem cells for personal use. However, since 2007 the right to export and preserve them in private laboratories located outside Italy has existed, and an increasing number of women are requesting this collection of umbilical CB at delivery to enable storage of stem cells for autologous use.
STUDY DESIGN AND METHODS: Since private banks recruit clients mainly via the Internet, we examined the content of 24 Italian‐language websites that offer stem cells storage (from CB or amniotic fluid), to assess what information is available.
RESULTS: We found that the majority of private banks give no clear information about the procedures of collection, processing, and banking of CB units and that the standards offered by private CB banks strongly differ in terms of exclusion or acceptance criteria from the public banks. These factors may well influence the overall quality of the CB units stored in private CB banks. Of note, during the period 2007 to 2009, the number collected for autologous use did not create a downward trend on the number of units stored in public CB banks for allogeneic use.
CONCLUSION: CB is a valuable community resource but expectant parents should be better informed as to the quality variables necessary for its storage, both by institutions and by professionals. Currently, most of the advertising is insufficient to justify the expense and the hopes pinned on autologous use of CB stem cells.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Banks - statistics & numerical data</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cryopreservation</subject><subject>Fetal Blood</subject><subject>Humans</subject><subject>Italy</subject><subject>Medical sciences</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1PwyAUhonR6Pz4C4Yb41XroUBLTbwwi5smRpPFj0sChSqzK7N0cfv3tm7OW88NJDwv5_CAECYQk64upjHhNIuSPOdxAoTEQEHk8XIHDbYHu2gAwEhECE0O0GEIUwBIciD76CAhjAjIxABdD31jsK68Nzi0doYLW1VYq_rD1W-XWOFQq3l49y32JW7fLb5rVeVUjYNrF6p1vj5Ge6Wqgj3ZrEfoeXTzNLyN7h_Hd8Pr-6hgNM0jI5hJU8GoLfPUUlpwzpRgrORGa2qoThntq-ieo00CmgtBgLEk49roktAjdL6-d974z4UNrZy50E-rausXQQohIAcgoiPFmiwaH0JjSzlv3Ew1K0lA9v7kVPaaZK9J9v7kjz-57KKnmyYLPbNmG_wV1gFnG0CFQlVlo-rChT-O8ZQygI67WnNfrrKrfw8gnyajftflo3Xedb-y3OZV8yHTjGZcvj6MJZ3k2ctkNJacfgNZFJhg</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Capone, Francesca</creator><creator>Lombardini, Letizia</creator><creator>Pupella, Simonetta</creator><creator>Grazzini, Giuliano</creator><creator>Costa, Alessandro Nanni</creator><creator>Migliaccio, Giovanni</creator><general>Blackwell Publishing Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Cord blood stem cell banking: a snapshot of the Italian situation</title><author>Capone, Francesca ; Lombardini, Letizia ; Pupella, Simonetta ; Grazzini, Giuliano ; Costa, Alessandro Nanni ; Migliaccio, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4369-d84d66843ef96e33c554a844f5dbb3d3b6433333c011bd20b5881044275bdbf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Banks - statistics & numerical data</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Cryopreservation</topic><topic>Fetal Blood</topic><topic>Humans</topic><topic>Italy</topic><topic>Medical sciences</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Capone, Francesca</creatorcontrib><creatorcontrib>Lombardini, Letizia</creatorcontrib><creatorcontrib>Pupella, Simonetta</creatorcontrib><creatorcontrib>Grazzini, Giuliano</creatorcontrib><creatorcontrib>Costa, Alessandro Nanni</creatorcontrib><creatorcontrib>Migliaccio, Giovanni</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Capone, Francesca</au><au>Lombardini, Letizia</au><au>Pupella, Simonetta</au><au>Grazzini, Giuliano</au><au>Costa, Alessandro Nanni</au><au>Migliaccio, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cord blood stem cell banking: a snapshot of the Italian situation</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2011-09</date><risdate>2011</risdate><volume>51</volume><issue>9</issue><spage>1985</spage><epage>1994</epage><pages>1985-1994</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: In Italy, the law does not permit the setting up of private banks to preserve cord blood (CB) stem cells for personal use. However, since 2007 the right to export and preserve them in private laboratories located outside Italy has existed, and an increasing number of women are requesting this collection of umbilical CB at delivery to enable storage of stem cells for autologous use.
STUDY DESIGN AND METHODS: Since private banks recruit clients mainly via the Internet, we examined the content of 24 Italian‐language websites that offer stem cells storage (from CB or amniotic fluid), to assess what information is available.
RESULTS: We found that the majority of private banks give no clear information about the procedures of collection, processing, and banking of CB units and that the standards offered by private CB banks strongly differ in terms of exclusion or acceptance criteria from the public banks. These factors may well influence the overall quality of the CB units stored in private CB banks. Of note, during the period 2007 to 2009, the number collected for autologous use did not create a downward trend on the number of units stored in public CB banks for allogeneic use.
CONCLUSION: CB is a valuable community resource but expectant parents should be better informed as to the quality variables necessary for its storage, both by institutions and by professionals. Currently, most of the advertising is insufficient to justify the expense and the hopes pinned on autologous use of CB stem cells.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21418078</pmid><doi>10.1111/j.1537-2995.2011.03089.x</doi><tpages>10</tpages></addata></record> |
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subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Banks - statistics & numerical data Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Cryopreservation Fetal Blood Humans Italy Medical sciences Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
title | Cord blood stem cell banking: a snapshot of the Italian situation |
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