Follicular nodules (THY3) of the thyroid: We recommend surgery
Objective: To determine the need of total thyrodectomy for patients with follicular nodules of thyroid. Subjects and methods: From January 2005 through June 2008, 2249 consecutive patients (438 males, 1811 females; mean age 54 yr, range 9–87) with thyroid nodules were submitted to 2518 ultrasound-gu...
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| Veröffentlicht in: | Journal of endocrinological investigation 2011-07, Vol.34 (7), p.e183-e187 |
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| container_title | Journal of endocrinological investigation |
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| creator | Gheri, R. G. Romoli, E. Vezzosi, V. Ragghianti, B. Bianchi, S. Pedercini, S. Dainelli, F. Panconesi, R. |
| description | Objective:
To determine the need of total thyrodectomy for patients with follicular nodules of thyroid.
Subjects and methods:
From January 2005 through June 2008, 2249 consecutive patients (438 males, 1811 females; mean age 54 yr, range 9–87) with thyroid nodules were submitted to 2518 ultrasound-guided fine-needle aspiration (USgFNA) for cytological examination. USgFNA were performed by experienced surgeon (RP) and endocrinologist (RGG) under ultra-sonographyc guidance, using a 10-MHz linear transducer. Liquid-based cytology was used.
Results:
All cytological samples were classified in 5 diagnostic classes (THY1, THY2, THY3, THY4, THY5) in agreement with the British Thyroid Association (BTA); 1.4% specimen were classified as THY5, 2.1 % as THY4, 7.6% as THY3, 79.5% as THY2 and 9.4% as THY1. In 97% of THY5 patients, malignancy was found. Among THY4 patients, 95.5% were positive for thyroid tumor. Among THY3 patients, malignancy was found in 29.1%. THY3 patients with thyroid tumors were younger than those with benign lesions (46±14.1 yr
vs
50±13.8 yr;
p
95% both in THY5 and THY4, and >29% in THY3 lesions). Our proposal is to submit to total thyroidectomy all patients with THY5 and THY4 lesions and THY3 thyroid nodule >1 cm. |
| doi_str_mv | 10.3275/7416 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_888089445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>888089445</sourcerecordid><originalsourceid>FETCH-LOGICAL-p240t-895fb01dbeb8c8e6dfc556fb69a90856d1017ad50f15c9edd7ea1c037a974f953</originalsourceid><addsrcrecordid>eNo1kEFLAzEUhIMotrb-BclF1MNqstlsEg-CFGuFgpeKeArZ5K1uyW5q0j3037ul9TC8w3w8ZgahKSX3LBf8QRS0PEFjKnKSSSbLUzQmTNGsIEqM0EVKa0KYYFKco1FOaalErsboaR68b2zvTcRdcL2HhG9Xiy92h0ONtz8waBdD4x7xJ-AINrQtdA6nPn5D3E3RWW18gsvjnaCP-ctqtsiW769vs-dltskLss2k4nVFqKugklZC6WrLeVlXpTKKSF46SqgwjpOacqvAOQGG2iGuUaKoFWcTdHP4u4nht4e01W2TLHhvOgh90lJKIlVR7MmrI9lXLTi9iU1r4k7_Vx6A6wOQBqsbSuh16GM3pNeU6P2Uej8l-wPbSWFk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>888089445</pqid></control><display><type>article</type><title>Follicular nodules (THY3) of the thyroid: We recommend surgery</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Gheri, R. G. ; Romoli, E. ; Vezzosi, V. ; Ragghianti, B. ; Bianchi, S. ; Pedercini, S. ; Dainelli, F. ; Panconesi, R.</creator><creatorcontrib>Gheri, R. G. ; Romoli, E. ; Vezzosi, V. ; Ragghianti, B. ; Bianchi, S. ; Pedercini, S. ; Dainelli, F. ; Panconesi, R.</creatorcontrib><description>Objective:
To determine the need of total thyrodectomy for patients with follicular nodules of thyroid.
Subjects and methods:
From January 2005 through June 2008, 2249 consecutive patients (438 males, 1811 females; mean age 54 yr, range 9–87) with thyroid nodules were submitted to 2518 ultrasound-guided fine-needle aspiration (USgFNA) for cytological examination. USgFNA were performed by experienced surgeon (RP) and endocrinologist (RGG) under ultra-sonographyc guidance, using a 10-MHz linear transducer. Liquid-based cytology was used.
Results:
All cytological samples were classified in 5 diagnostic classes (THY1, THY2, THY3, THY4, THY5) in agreement with the British Thyroid Association (BTA); 1.4% specimen were classified as THY5, 2.1 % as THY4, 7.6% as THY3, 79.5% as THY2 and 9.4% as THY1. In 97% of THY5 patients, malignancy was found. Among THY4 patients, 95.5% were positive for thyroid tumor. Among THY3 patients, malignancy was found in 29.1%. THY3 patients with thyroid tumors were younger than those with benign lesions (46±14.1 yr
vs
50±13.8 yr;
p
<0.05, t test). No statistical difference was found neither in malignancy frequency among men and women nor in mean size of nodules (24±11.8 mm malignant
vs
23 ± 9.4 mm benign).
Conclusions:
this study provides evidence that USgFNA offers a very sensitive and accurate method in reducing THY1 samples and in detecting malignancy (>95% both in THY5 and THY4, and >29% in THY3 lesions). Our proposal is to submit to total thyroidectomy all patients with THY5 and THY4 lesions and THY3 thyroid nodule >1 cm.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.3275/7416</identifier><identifier>PMID: 21169729</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle - methods ; Child ; Cytodiagnosis - methods ; Electronic Contents ; Endocrinology ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Retrospective Studies ; Thyroid Gland - diagnostic imaging ; Thyroid Gland - pathology ; Thyroid Gland - surgery ; Thyroid Nodule - classification ; Thyroid Nodule - diagnostic imaging ; Thyroid Nodule - pathology ; Thyroid Nodule - surgery ; Thyroidectomy ; Ultrasonography ; Young Adult</subject><ispartof>Journal of endocrinological investigation, 2011-07, Vol.34 (7), p.e183-e187</ispartof><rights>Italian Society of Endocrinology (SIE) 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p240t-895fb01dbeb8c8e6dfc556fb69a90856d1017ad50f15c9edd7ea1c037a974f953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3275/7416$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3275/7416$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21169729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gheri, R. G.</creatorcontrib><creatorcontrib>Romoli, E.</creatorcontrib><creatorcontrib>Vezzosi, V.</creatorcontrib><creatorcontrib>Ragghianti, B.</creatorcontrib><creatorcontrib>Bianchi, S.</creatorcontrib><creatorcontrib>Pedercini, S.</creatorcontrib><creatorcontrib>Dainelli, F.</creatorcontrib><creatorcontrib>Panconesi, R.</creatorcontrib><title>Follicular nodules (THY3) of the thyroid: We recommend surgery</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Objective:
To determine the need of total thyrodectomy for patients with follicular nodules of thyroid.
Subjects and methods:
From January 2005 through June 2008, 2249 consecutive patients (438 males, 1811 females; mean age 54 yr, range 9–87) with thyroid nodules were submitted to 2518 ultrasound-guided fine-needle aspiration (USgFNA) for cytological examination. USgFNA were performed by experienced surgeon (RP) and endocrinologist (RGG) under ultra-sonographyc guidance, using a 10-MHz linear transducer. Liquid-based cytology was used.
Results:
All cytological samples were classified in 5 diagnostic classes (THY1, THY2, THY3, THY4, THY5) in agreement with the British Thyroid Association (BTA); 1.4% specimen were classified as THY5, 2.1 % as THY4, 7.6% as THY3, 79.5% as THY2 and 9.4% as THY1. In 97% of THY5 patients, malignancy was found. Among THY4 patients, 95.5% were positive for thyroid tumor. Among THY3 patients, malignancy was found in 29.1%. THY3 patients with thyroid tumors were younger than those with benign lesions (46±14.1 yr
vs
50±13.8 yr;
p
<0.05, t test). No statistical difference was found neither in malignancy frequency among men and women nor in mean size of nodules (24±11.8 mm malignant
vs
23 ± 9.4 mm benign).
Conclusions:
this study provides evidence that USgFNA offers a very sensitive and accurate method in reducing THY1 samples and in detecting malignancy (>95% both in THY5 and THY4, and >29% in THY3 lesions). Our proposal is to submit to total thyroidectomy all patients with THY5 and THY4 lesions and THY3 thyroid nodule >1 cm.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy, Fine-Needle - methods</subject><subject>Child</subject><subject>Cytodiagnosis - methods</subject><subject>Electronic Contents</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Gland - surgery</subject><subject>Thyroid Nodule - classification</subject><subject>Thyroid Nodule - diagnostic imaging</subject><subject>Thyroid Nodule - pathology</subject><subject>Thyroid Nodule - surgery</subject><subject>Thyroidectomy</subject><subject>Ultrasonography</subject><subject>Young Adult</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEFLAzEUhIMotrb-BclF1MNqstlsEg-CFGuFgpeKeArZ5K1uyW5q0j3037ul9TC8w3w8ZgahKSX3LBf8QRS0PEFjKnKSSSbLUzQmTNGsIEqM0EVKa0KYYFKco1FOaalErsboaR68b2zvTcRdcL2HhG9Xiy92h0ONtz8waBdD4x7xJ-AINrQtdA6nPn5D3E3RWW18gsvjnaCP-ctqtsiW769vs-dltskLss2k4nVFqKugklZC6WrLeVlXpTKKSF46SqgwjpOacqvAOQGG2iGuUaKoFWcTdHP4u4nht4e01W2TLHhvOgh90lJKIlVR7MmrI9lXLTi9iU1r4k7_Vx6A6wOQBqsbSuh16GM3pNeU6P2Uej8l-wPbSWFk</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Gheri, R. G.</creator><creator>Romoli, E.</creator><creator>Vezzosi, V.</creator><creator>Ragghianti, B.</creator><creator>Bianchi, S.</creator><creator>Pedercini, S.</creator><creator>Dainelli, F.</creator><creator>Panconesi, R.</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Follicular nodules (THY3) of the thyroid: We recommend surgery</title><author>Gheri, R. G. ; Romoli, E. ; Vezzosi, V. ; Ragghianti, B. ; Bianchi, S. ; Pedercini, S. ; Dainelli, F. ; Panconesi, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p240t-895fb01dbeb8c8e6dfc556fb69a90856d1017ad50f15c9edd7ea1c037a974f953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy, Fine-Needle - methods</topic><topic>Child</topic><topic>Cytodiagnosis - methods</topic><topic>Electronic Contents</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Gland - surgery</topic><topic>Thyroid Nodule - classification</topic><topic>Thyroid Nodule - diagnostic imaging</topic><topic>Thyroid Nodule - pathology</topic><topic>Thyroid Nodule - surgery</topic><topic>Thyroidectomy</topic><topic>Ultrasonography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gheri, R. G.</creatorcontrib><creatorcontrib>Romoli, E.</creatorcontrib><creatorcontrib>Vezzosi, V.</creatorcontrib><creatorcontrib>Ragghianti, B.</creatorcontrib><creatorcontrib>Bianchi, S.</creatorcontrib><creatorcontrib>Pedercini, S.</creatorcontrib><creatorcontrib>Dainelli, F.</creatorcontrib><creatorcontrib>Panconesi, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gheri, R. G.</au><au>Romoli, E.</au><au>Vezzosi, V.</au><au>Ragghianti, B.</au><au>Bianchi, S.</au><au>Pedercini, S.</au><au>Dainelli, F.</au><au>Panconesi, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follicular nodules (THY3) of the thyroid: We recommend surgery</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>34</volume><issue>7</issue><spage>e183</spage><epage>e187</epage><pages>e183-e187</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Objective:
To determine the need of total thyrodectomy for patients with follicular nodules of thyroid.
Subjects and methods:
From January 2005 through June 2008, 2249 consecutive patients (438 males, 1811 females; mean age 54 yr, range 9–87) with thyroid nodules were submitted to 2518 ultrasound-guided fine-needle aspiration (USgFNA) for cytological examination. USgFNA were performed by experienced surgeon (RP) and endocrinologist (RGG) under ultra-sonographyc guidance, using a 10-MHz linear transducer. Liquid-based cytology was used.
Results:
All cytological samples were classified in 5 diagnostic classes (THY1, THY2, THY3, THY4, THY5) in agreement with the British Thyroid Association (BTA); 1.4% specimen were classified as THY5, 2.1 % as THY4, 7.6% as THY3, 79.5% as THY2 and 9.4% as THY1. In 97% of THY5 patients, malignancy was found. Among THY4 patients, 95.5% were positive for thyroid tumor. Among THY3 patients, malignancy was found in 29.1%. THY3 patients with thyroid tumors were younger than those with benign lesions (46±14.1 yr
vs
50±13.8 yr;
p
<0.05, t test). No statistical difference was found neither in malignancy frequency among men and women nor in mean size of nodules (24±11.8 mm malignant
vs
23 ± 9.4 mm benign).
Conclusions:
this study provides evidence that USgFNA offers a very sensitive and accurate method in reducing THY1 samples and in detecting malignancy (>95% both in THY5 and THY4, and >29% in THY3 lesions). Our proposal is to submit to total thyroidectomy all patients with THY5 and THY4 lesions and THY3 thyroid nodule >1 cm.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>21169729</pmid><doi>10.3275/7416</doi></addata></record> |
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| issn | 0391-4097 1720-8386 |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biopsy, Fine-Needle - methods Child Cytodiagnosis - methods Electronic Contents Endocrinology Female Humans Male Medicine Medicine & Public Health Metabolic Diseases Middle Aged Retrospective Studies Thyroid Gland - diagnostic imaging Thyroid Gland - pathology Thyroid Gland - surgery Thyroid Nodule - classification Thyroid Nodule - diagnostic imaging Thyroid Nodule - pathology Thyroid Nodule - surgery Thyroidectomy Ultrasonography Young Adult |
| title | Follicular nodules (THY3) of the thyroid: We recommend surgery |
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