Contributions of angiogenesis to inflammation, joint damage, and pain in a rat model of osteoarthritis

Objective To determine the contributions of angiogenesis to inflammation, joint damage, and pain behavior in a rat meniscal transection model of osteoarthritis (OA). Methods OA was induced in male Lewis rats (n = 8 per group) by meniscal transection. Animals were orally dosed with dexamethasone (0.1...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2011-09, Vol.63 (9), p.2700-2710
Hauptverfasser:	Ashraf, Sadaf, Mapp, Paul I., Walsh, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis angiogenesis inhibitors Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Asymmetry Behavior, Animal - drug effects Biological and medical sciences Cartilage, Articular - drug effects Cartilage, Articular - pathology Cartilage, Articular - physiopathology Dexamethasone Dexamethasone - pharmacology Dexamethasone - therapeutic use Diseases of the osteoarticular system Endothelial cells Glucocorticoids - pharmacology Glucocorticoids - therapeutic use Indomethacin Indomethacin - pharmacology Indomethacin - therapeutic use Inflammation Inflammation - complications Inflammation - pathology Inflammation - physiopathology Joint diseases Joints - drug effects Joints - pathology Joints - physiopathology Macrophages Male Medical sciences meniscus Miscellaneous. Osteoarticular involvement in other diseases Neovascularization, Pathologic - complications Neovascularization, Pathologic - pathology Neovascularization, Pathologic - physiopathology Osteoarthritis Osteoarthritis - complications Osteoarthritis - pathology Osteoarthritis - physiopathology Pain Pain - complications Pain - drug therapy Pain - pathology Pain - physiopathology Pain Measurement Rats Rats, Inbred Lew Rheumatism Rodents Synovitis Weight-Bearing - physiology
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