Endocrine Effects of the Tyrosine Kinase Inhibitor Vandetanib in Patients Treated for Thyroid Cancer

Purpose: The purpose of the study was to assess the endocrine effects of vandetanib, a multikinase inhibitor targeting RET, vascular endothelial growth factor receptor, and epidermal growth factor receptor, in 39 patients with progressive thyroid cancer included in two randomized placebo-controlled...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2011-09, Vol.96 (9), p.2741-2749
Hauptverfasser:	Brassard, Maryse, Neraud, Barbara, Trabado, Séverine, Salenave, Sylvie, Brailly-Tabard, Sylvie, Borget, Isabelle, Baudin, Eric, Leboulleux, Sophie, Chanson, Philippe, Schlumberger, Martin, Young, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Follicular - blood Adenocarcinoma, Follicular - drug therapy Adenocarcinoma, Papillary - blood Adenocarcinoma, Papillary - drug therapy Adrenocorticotropic hormone Adult Aged Aged, 80 and over Biological and medical sciences Blood Glucose Calcium - blood Calcium metabolism Clinical trials Cortisol Cross-Over Studies Endocrinopathies Enzyme Inhibitors - therapeutic use ErbB Receptors - antagonists & inhibitors Feeding. Feeding behavior Female Follicle-stimulating hormone Fundamental and applied biological sciences. Psychology Globulins Growth factors Hormones Humans Inhibin Intestinal absorption Male Malignant tumors Medical sciences Metastases Middle Aged Parathyroid hormone Parathyroid Hormone - blood Photosensitization Piperidines - therapeutic use Pituitary (anterior) Placebos Proto-Oncogene Proteins c-ret - antagonists & inhibitors Quinazolines - therapeutic use Receptors, Vascular Endothelial Growth Factor - antagonists & inhibitors Ret protein Sertoli cells Testosterone Testosterone - blood Thyroid cancer Thyroid Neoplasms - drug therapy Thyroid-stimulating hormone Thyroid. Thyroid axis (diseases) Thyroxine Treatment Outcome Tyrosine kinase inhibitors Vascular endothelial growth factor Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Vitamin D Vitamin D - blood
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