Duplex ultrasound screening detects high rates of deep vein thromboses in critically ill trauma patients
Objective American College of Chest Physician (ACCP) guidelines stratify deep venous thrombosis (DVT) risk in trauma patients based on injury pattern and pharmacologic prophylaxis. Screening is only recommended for patients with high-risk injuries who are unable to receive pharmacologic prophylaxis....
Gespeichert in:
Veröffentlicht in: | Journal of vascular surgery 2011-09, Vol.54 (3), p.743-748 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 748 |
---|---|
container_issue | 3 |
container_start_page | 743 |
container_title | Journal of vascular surgery |
container_volume | 54 |
creator | Azarbal, Amir, MD Rowell, Susan, MD Lewis, Jason, BA Urankar, Rakhee, MD Moseley, Shannon, BA Landry, Gregory, MD Moneta, Greg, MD |
description | Objective American College of Chest Physician (ACCP) guidelines stratify deep venous thrombosis (DVT) risk in trauma patients based on injury pattern and pharmacologic prophylaxis. Screening is only recommended for patients with high-risk injuries who are unable to receive pharmacologic prophylaxis. However, the prevalence of lower extremity DVT (LEDVT) in trauma patients may be higher than reported in previous studies as many studies on DVT screening have not investigated calf vein DVTs (CVDVT) and have not exclusively targeted critically ill patients. Given that current ACCP guidelines recommend treatment of CVDVTs, we investigated the efficacy of duplex ultrasound (DUS) screening in critically ill trauma patients for all LEDVTs, including CVDVT, regardless of injury pattern, risk factors, or pharmacologic prophylaxis. Methods Medical records of 264 intensive care unit trauma patients who received DUS screening for LEDVT were retrospectively examined for the presence of injuries conferring high risk for LEDVT, patient specific DVT risk factors, and low molecular weight heparin (LMWH) prophylaxis. Results Forty (15.2%) patients had LEDVTs found on DUS screening, 24 (60%) were CVDVT, and 30% of all DVTs were diagnosed within 1 week of admission. Patients without high-risk injuries receiving LMWH had a 13.5% DVT rate, which did not differ significantly from the 19.7% DVT rate in high-risk injury patients not receiving LMWH ( P = .667). Conclusions Lower extremity DVT is common in critically ill trauma patients, particularly in the first week following injury, regardless of injury pattern, DVT risk factors, or pharmacologic prophylaxis. Previous studies have underestimated DVT rates by not investigating CVDVTs and not exclusively targeting critically ill patients. We recommend early and continued DUS DVT screening of all critically ill trauma patients. |
doi_str_mv | 10.1016/j.jvs.2011.02.058 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_887757519</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0741521411004241</els_id><sourcerecordid>887757519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-2159be8b292aefb50d38d265b68c6f2a81240ae84a0f3bb81a1eba4fc64ac1813</originalsourceid><addsrcrecordid>eNp9kk2r1DAUhoMo3vHqD3Aj2Yir1pxM2qYIglw_4YILdR3S9PROar_MSQfn35syo4ILVyGH5305PBzGnoLIQUD5ss_7I-VSAORC5qLQ99gORF1lpRb1fbYTlYKskKCu2COiXiSw0NVDdiWhlKIEtWOHt-sy4E--DjFYmtep5eQC4uSnO95iRBeJH_zdgQcbkfjcpSku_Ih-4vEQ5rGZKc3TzwUfvbPDcOJ-GHjqW0fLFxs9TpEeswedHQifXN5r9u39u683H7Pbzx8-3by5zZzSImYSirpB3chaWuyaQrR73cqyaErtyk5aDVIJi1pZ0e2bRoMFbKzqXKmsAw37a_bi3LuE-ceKFM3oyeEw2AnnlYzWVVVUBdSJhDPpwkwUsDNL8KMNJwPCbH5Nb5Jfs_k1QprkN2WeXdrXZsT2T-K30AQ8vwCWkosu2Ml5-supIhXX25qvzhwmF0ePwZBLnhy2PiTnpp39f9d4_U_aDX7a5H_HE1I_r2FKkg0YSgHzZTuE7Q4AhFBSwf4Xtbqu3g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>887757519</pqid></control><display><type>article</type><title>Duplex ultrasound screening detects high rates of deep vein thromboses in critically ill trauma patients</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via ScienceDirect (Elsevier)</source><creator>Azarbal, Amir, MD ; Rowell, Susan, MD ; Lewis, Jason, BA ; Urankar, Rakhee, MD ; Moseley, Shannon, BA ; Landry, Gregory, MD ; Moneta, Greg, MD</creator><creatorcontrib>Azarbal, Amir, MD ; Rowell, Susan, MD ; Lewis, Jason, BA ; Urankar, Rakhee, MD ; Moseley, Shannon, BA ; Landry, Gregory, MD ; Moneta, Greg, MD</creatorcontrib><description>Objective American College of Chest Physician (ACCP) guidelines stratify deep venous thrombosis (DVT) risk in trauma patients based on injury pattern and pharmacologic prophylaxis. Screening is only recommended for patients with high-risk injuries who are unable to receive pharmacologic prophylaxis. However, the prevalence of lower extremity DVT (LEDVT) in trauma patients may be higher than reported in previous studies as many studies on DVT screening have not investigated calf vein DVTs (CVDVT) and have not exclusively targeted critically ill patients. Given that current ACCP guidelines recommend treatment of CVDVTs, we investigated the efficacy of duplex ultrasound (DUS) screening in critically ill trauma patients for all LEDVTs, including CVDVT, regardless of injury pattern, risk factors, or pharmacologic prophylaxis. Methods Medical records of 264 intensive care unit trauma patients who received DUS screening for LEDVT were retrospectively examined for the presence of injuries conferring high risk for LEDVT, patient specific DVT risk factors, and low molecular weight heparin (LMWH) prophylaxis. Results Forty (15.2%) patients had LEDVTs found on DUS screening, 24 (60%) were CVDVT, and 30% of all DVTs were diagnosed within 1 week of admission. Patients without high-risk injuries receiving LMWH had a 13.5% DVT rate, which did not differ significantly from the 19.7% DVT rate in high-risk injury patients not receiving LMWH ( P = .667). Conclusions Lower extremity DVT is common in critically ill trauma patients, particularly in the first week following injury, regardless of injury pattern, DVT risk factors, or pharmacologic prophylaxis. Previous studies have underestimated DVT rates by not investigating CVDVTs and not exclusively targeting critically ill patients. We recommend early and continued DUS DVT screening of all critically ill trauma patients.</description><identifier>ISSN: 0741-5214</identifier><identifier>EISSN: 1097-6809</identifier><identifier>DOI: 10.1016/j.jvs.2011.02.058</identifier><identifier>PMID: 21620614</identifier><identifier>CODEN: JVSUES</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; Anticoagulants - administration & dosage ; Biological and medical sciences ; Cardiovascular system ; Critical Illness ; Female ; Humans ; Intensive Care Units ; Investigative techniques, diagnostic techniques (general aspects) ; Lower Extremity - blood supply ; Male ; Medical sciences ; Middle Aged ; Oregon ; Practice Guidelines as Topic ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Trauma Centers ; Ultrasonic investigative techniques ; Ultrasonography, Doppler, Duplex ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels ; Venous Thrombosis - diagnostic imaging ; Venous Thrombosis - etiology ; Venous Thrombosis - prevention & control ; Wounds and Injuries - complications ; Wounds and Injuries - diagnostic imaging ; Wounds and Injuries - drug therapy</subject><ispartof>Journal of vascular surgery, 2011-09, Vol.54 (3), p.743-748</ispartof><rights>Society for Vascular Surgery</rights><rights>2011 Society for Vascular Surgery</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-2159be8b292aefb50d38d265b68c6f2a81240ae84a0f3bb81a1eba4fc64ac1813</citedby><cites>FETCH-LOGICAL-c480t-2159be8b292aefb50d38d265b68c6f2a81240ae84a0f3bb81a1eba4fc64ac1813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jvs.2011.02.058$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>310,311,315,781,785,790,791,3551,23935,23936,25145,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24501691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21620614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azarbal, Amir, MD</creatorcontrib><creatorcontrib>Rowell, Susan, MD</creatorcontrib><creatorcontrib>Lewis, Jason, BA</creatorcontrib><creatorcontrib>Urankar, Rakhee, MD</creatorcontrib><creatorcontrib>Moseley, Shannon, BA</creatorcontrib><creatorcontrib>Landry, Gregory, MD</creatorcontrib><creatorcontrib>Moneta, Greg, MD</creatorcontrib><title>Duplex ultrasound screening detects high rates of deep vein thromboses in critically ill trauma patients</title><title>Journal of vascular surgery</title><addtitle>J Vasc Surg</addtitle><description>Objective American College of Chest Physician (ACCP) guidelines stratify deep venous thrombosis (DVT) risk in trauma patients based on injury pattern and pharmacologic prophylaxis. Screening is only recommended for patients with high-risk injuries who are unable to receive pharmacologic prophylaxis. However, the prevalence of lower extremity DVT (LEDVT) in trauma patients may be higher than reported in previous studies as many studies on DVT screening have not investigated calf vein DVTs (CVDVT) and have not exclusively targeted critically ill patients. Given that current ACCP guidelines recommend treatment of CVDVTs, we investigated the efficacy of duplex ultrasound (DUS) screening in critically ill trauma patients for all LEDVTs, including CVDVT, regardless of injury pattern, risk factors, or pharmacologic prophylaxis. Methods Medical records of 264 intensive care unit trauma patients who received DUS screening for LEDVT were retrospectively examined for the presence of injuries conferring high risk for LEDVT, patient specific DVT risk factors, and low molecular weight heparin (LMWH) prophylaxis. Results Forty (15.2%) patients had LEDVTs found on DUS screening, 24 (60%) were CVDVT, and 30% of all DVTs were diagnosed within 1 week of admission. Patients without high-risk injuries receiving LMWH had a 13.5% DVT rate, which did not differ significantly from the 19.7% DVT rate in high-risk injury patients not receiving LMWH ( P = .667). Conclusions Lower extremity DVT is common in critically ill trauma patients, particularly in the first week following injury, regardless of injury pattern, DVT risk factors, or pharmacologic prophylaxis. Previous studies have underestimated DVT rates by not investigating CVDVTs and not exclusively targeting critically ill patients. We recommend early and continued DUS DVT screening of all critically ill trauma patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Anticoagulants - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Critical Illness</subject><subject>Female</subject><subject>Humans</subject><subject>Intensive Care Units</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lower Extremity - blood supply</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oregon</subject><subject>Practice Guidelines as Topic</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><subject>Trauma Centers</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography, Doppler, Duplex</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><subject>Venous Thrombosis - diagnostic imaging</subject><subject>Venous Thrombosis - etiology</subject><subject>Venous Thrombosis - prevention & control</subject><subject>Wounds and Injuries - complications</subject><subject>Wounds and Injuries - diagnostic imaging</subject><subject>Wounds and Injuries - drug therapy</subject><issn>0741-5214</issn><issn>1097-6809</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk2r1DAUhoMo3vHqD3Aj2Yir1pxM2qYIglw_4YILdR3S9PROar_MSQfn35syo4ILVyGH5305PBzGnoLIQUD5ss_7I-VSAORC5qLQ99gORF1lpRb1fbYTlYKskKCu2COiXiSw0NVDdiWhlKIEtWOHt-sy4E--DjFYmtep5eQC4uSnO95iRBeJH_zdgQcbkfjcpSku_Ih-4vEQ5rGZKc3TzwUfvbPDcOJ-GHjqW0fLFxs9TpEeswedHQifXN5r9u39u683H7Pbzx8-3by5zZzSImYSirpB3chaWuyaQrR73cqyaErtyk5aDVIJi1pZ0e2bRoMFbKzqXKmsAw37a_bi3LuE-ceKFM3oyeEw2AnnlYzWVVVUBdSJhDPpwkwUsDNL8KMNJwPCbH5Nb5Jfs_k1QprkN2WeXdrXZsT2T-K30AQ8vwCWkosu2Ml5-supIhXX25qvzhwmF0ePwZBLnhy2PiTnpp39f9d4_U_aDX7a5H_HE1I_r2FKkg0YSgHzZTuE7Q4AhFBSwf4Xtbqu3g</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Azarbal, Amir, MD</creator><creator>Rowell, Susan, MD</creator><creator>Lewis, Jason, BA</creator><creator>Urankar, Rakhee, MD</creator><creator>Moseley, Shannon, BA</creator><creator>Landry, Gregory, MD</creator><creator>Moneta, Greg, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Duplex ultrasound screening detects high rates of deep vein thromboses in critically ill trauma patients</title><author>Azarbal, Amir, MD ; Rowell, Susan, MD ; Lewis, Jason, BA ; Urankar, Rakhee, MD ; Moseley, Shannon, BA ; Landry, Gregory, MD ; Moneta, Greg, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-2159be8b292aefb50d38d265b68c6f2a81240ae84a0f3bb81a1eba4fc64ac1813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anticoagulants - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Critical Illness</topic><topic>Female</topic><topic>Humans</topic><topic>Intensive Care Units</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lower Extremity - blood supply</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oregon</topic><topic>Practice Guidelines as Topic</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><topic>Trauma Centers</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography, Doppler, Duplex</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><topic>Venous Thrombosis - diagnostic imaging</topic><topic>Venous Thrombosis - etiology</topic><topic>Venous Thrombosis - prevention & control</topic><topic>Wounds and Injuries - complications</topic><topic>Wounds and Injuries - diagnostic imaging</topic><topic>Wounds and Injuries - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azarbal, Amir, MD</creatorcontrib><creatorcontrib>Rowell, Susan, MD</creatorcontrib><creatorcontrib>Lewis, Jason, BA</creatorcontrib><creatorcontrib>Urankar, Rakhee, MD</creatorcontrib><creatorcontrib>Moseley, Shannon, BA</creatorcontrib><creatorcontrib>Landry, Gregory, MD</creatorcontrib><creatorcontrib>Moneta, Greg, MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of vascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azarbal, Amir, MD</au><au>Rowell, Susan, MD</au><au>Lewis, Jason, BA</au><au>Urankar, Rakhee, MD</au><au>Moseley, Shannon, BA</au><au>Landry, Gregory, MD</au><au>Moneta, Greg, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duplex ultrasound screening detects high rates of deep vein thromboses in critically ill trauma patients</atitle><jtitle>Journal of vascular surgery</jtitle><addtitle>J Vasc Surg</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>54</volume><issue>3</issue><spage>743</spage><epage>748</epage><pages>743-748</pages><issn>0741-5214</issn><eissn>1097-6809</eissn><coden>JVSUES</coden><abstract>Objective American College of Chest Physician (ACCP) guidelines stratify deep venous thrombosis (DVT) risk in trauma patients based on injury pattern and pharmacologic prophylaxis. Screening is only recommended for patients with high-risk injuries who are unable to receive pharmacologic prophylaxis. However, the prevalence of lower extremity DVT (LEDVT) in trauma patients may be higher than reported in previous studies as many studies on DVT screening have not investigated calf vein DVTs (CVDVT) and have not exclusively targeted critically ill patients. Given that current ACCP guidelines recommend treatment of CVDVTs, we investigated the efficacy of duplex ultrasound (DUS) screening in critically ill trauma patients for all LEDVTs, including CVDVT, regardless of injury pattern, risk factors, or pharmacologic prophylaxis. Methods Medical records of 264 intensive care unit trauma patients who received DUS screening for LEDVT were retrospectively examined for the presence of injuries conferring high risk for LEDVT, patient specific DVT risk factors, and low molecular weight heparin (LMWH) prophylaxis. Results Forty (15.2%) patients had LEDVTs found on DUS screening, 24 (60%) were CVDVT, and 30% of all DVTs were diagnosed within 1 week of admission. Patients without high-risk injuries receiving LMWH had a 13.5% DVT rate, which did not differ significantly from the 19.7% DVT rate in high-risk injury patients not receiving LMWH ( P = .667). Conclusions Lower extremity DVT is common in critically ill trauma patients, particularly in the first week following injury, regardless of injury pattern, DVT risk factors, or pharmacologic prophylaxis. Previous studies have underestimated DVT rates by not investigating CVDVTs and not exclusively targeting critically ill patients. We recommend early and continued DUS DVT screening of all critically ill trauma patients.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>21620614</pmid><doi>10.1016/j.jvs.2011.02.058</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0741-5214 |
ispartof | Journal of vascular surgery, 2011-09, Vol.54 (3), p.743-748 |
issn | 0741-5214 1097-6809 |
language | eng |
recordid | cdi_proquest_miscellaneous_887757519 |
source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
subjects | Adult Aged Anticoagulants - administration & dosage Biological and medical sciences Cardiovascular system Critical Illness Female Humans Intensive Care Units Investigative techniques, diagnostic techniques (general aspects) Lower Extremity - blood supply Male Medical sciences Middle Aged Oregon Practice Guidelines as Topic Predictive Value of Tests Prognosis Retrospective Studies Risk Assessment Risk Factors Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Trauma Centers Ultrasonic investigative techniques Ultrasonography, Doppler, Duplex Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Venous Thrombosis - diagnostic imaging Venous Thrombosis - etiology Venous Thrombosis - prevention & control Wounds and Injuries - complications Wounds and Injuries - diagnostic imaging Wounds and Injuries - drug therapy |
title | Duplex ultrasound screening detects high rates of deep vein thromboses in critically ill trauma patients |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-12T18%3A52%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Duplex%20ultrasound%20screening%20detects%20high%20rates%20of%20deep%20vein%20thromboses%20in%20critically%20ill%20trauma%20patients&rft.jtitle=Journal%20of%20vascular%20surgery&rft.au=Azarbal,%20Amir,%20MD&rft.date=2011-09-01&rft.volume=54&rft.issue=3&rft.spage=743&rft.epage=748&rft.pages=743-748&rft.issn=0741-5214&rft.eissn=1097-6809&rft.coden=JVSUES&rft_id=info:doi/10.1016/j.jvs.2011.02.058&rft_dat=%3Cproquest_cross%3E887757519%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=887757519&rft_id=info:pmid/21620614&rft_els_id=1_s2_0_S0741521411004241&rfr_iscdi=true |