Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzobfuran (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

A structure-activity relationship (SAR) guided design of novel tubulin polymerization inhibitors has resulted in a series of benzo[b]furans with exceptional potency toward cancer cells and activated endothelial cells. The potency of early lead compounds has been substantially improved through the sy...

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Veröffentlicht in:	Journal of medicinal chemistry 2011-09, Vol.54 (17), p.6014
Hauptverfasser:	Flynn, Bernard L, Gill, Gurmit S, Grobelny, Damian W, Chaplin, Jason H, Paul, Dharam, Leske, Annabell F, Lavranos, Tina C, Chalmers, David K, Charman, Susan A, Kostewicz, Edmund, Shackleford, David M, Morizzi, Julia, Hamel, Ernest, Jung, M Katherine, Kremmidiotis, Gabriel
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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